Preconception preparation as a component of family planning services in modern conditions


  • Т. Ф Татарчук Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine, Ukraine
  • Т. Н. Тутченко Institute of Pediatrics, Obstetrics and Gynecology, NAM S of Ukraine, Ukraine



preconception care, family planning, preconception window, chronic stress, prolactin, functional hyperprolactinemia, recurrent pregnancy loss


This paper is a review of contemporary medical publications on preconception counseling and preconception care. It presents detailed review of such component of preconception care as prevention and correction of adverse effects of psychosocial stress of female reproductive function and descendants’ health.

It is need to provide correction of functional hyperprolactinemia at preconception counseling for women with stress-induced miscarriage in history

Author Biographies

Т. Ф Татарчук, Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine

MD, professor, corresponding member. NAMS of Ukraine, Deputy Director for Research, Head of Endocrine Gynecology

Т. Н. Тутченко, Institute of Pediatrics, Obstetrics and Gynecology, NAM S of Ukraine

PhD, researcher of the Endocrine Gynecology Department


  1. Family Planning. Education manual // Ed. by N.Y. Zhylka, I.B. Vovk. Kyiv (2010): 300 p.
  2. Johnson, K., Posner, S.F., Biermann, J., et al. CDC/AT SDR Preconception Care Work Group; Select Panel on Preconception Care. Recommendations to improve preconception health and health care – United States. MMWR Recomm Rep, 55(2006) (RR-6): 1–23.
  3. T emel, S., van Voorst, S.F., Jack, B.W., Denktaş, S., Steegers, E.A.P. “Evidence-Based Preconceptional Lifestyle Interventions.” Epidemiol Rev, 36(1) (2014): 19–30.
  4. Shannon, G.D., Alberg, C., Nacul, L., Pashayan, N. “Preconception Healthcare and Congenital Disorders: Systematic Review of the Effectiveness of Preconception Care Programs in the Prevention of Congenital Disorders.” Maternal and Child Health Journal, 18 (2014): 1354–1379.
  5. Lassi, Z.S., Imam, A.M., Dean, S.V., Bhutta, Z.A. “Preconception care: caffeine, smoking, alcohol, drugs and other environmental chemical/radiation exposure.” Reproductive Health, 11(2014) (Suppl 3): 6.
  6. Farahi, N., Zolotor, A. “Recommendations for preconception counseling and care.” 88(8) (2013): 499–506.
  7. D unlop, A.L., Jack, B.W., Bottalico, J.N., et al. “The clinical content of preconception care: women with chronic medical conditions.” Am J Obstet Gynecol, 199(2008) (6 Suppl 2): 310–327.
  8. D iabetes in Women - Pathophysiology and Therapy. // Ed. by A. Tsatsoulis, J. Wyckoff, F. Brown. Humana press (2009).
  9. Silver, R.M., Warren, J.E. “Preconception counseling for women with thrombophilia.” Clin Obstet Gynecol, 49(4) (2006): 906–919.
  10. M cDiarmid, M.A., Gehle, K. “Preconception brief: occupational/environmental exposures.” Matern Child Health J. 10(2006) (Suppl 5): 123–128.
  11. Shapira, S.K., Dolan, S. “Genetic risks to the mother and the infant: assessment, counseling, and management.” Matern Child Health J, 10(2006) (Suppl 5): 143–146.
  12. C ragan, J.D., Friedman, J.M., Holmes, L.B., Uhl, K., Green, N.S., Riley, L. “Ensuring the safe and effective use of medications during pregnancy: planning and prevention through preconception care.” Matern Child Health J, 10(2006) (Suppl 5): 129–135.
  13. Frieder, A., Dunlop, A.L., Culpepper, L., Bernstein, P.S. “The clinical content of preconception care: women with psychiatric conditions.” Am J Obstet Gynecol, 199(2008) (6 Suppl 2): 328–332.
  14. A merican College of Obstetricians and Gynecologists. Domestic violence. ACO G Education Bulletin 257. Washington, DC, ACO G (1999).
  15. Floyd, R.L., Jack, B.W., Cefalo, R., et al. “The clinical content of preconception care: alcohol, tobacco, and illicit drug exposures.” Am J Obstet Gynecol, 199(2008) (6 Suppl 2): 333–339.
  16. A ntenatal care: routine care for the healthy pregnant women. National Collaborating Centre for Women’s and Children’s Health; National Institute for Health and Clinical Excellence. London, England, RCO G Press (2008).
  17. Lumley, J., Watson, L., Watson, M., Bower, C. “Periconceptional supplementation with folate and/or multivitamins for preventing neural tube defects.” Cochrane Database Syst Rev, 2(2000): CD001056.
  18. E lsinga, J., de Jong-Potjer, L.C., van der Pal-de Bruin, K.M., le Cessie, S., Assendelft, W.J., Buitendijk, S.E. “The effect of preconception counselling on lifestyle and other behaviour before and during pregnancy.” Womens Health Issues, 18(2008) (Suppl 6): 117–125.
  19. W ilson, R.D., Davies, G., Désilets, V., et al. “Genetics Committee and Executive and Council of the Society of Obstetricians and Gynaecologists of Canada. The use of folic acid for the prevention of neural tube defects and other congenital anomalies.” J Obstet Gynaecol Can, 25(11) (2003): 959–973.
  20. MRC Vitamin Study Research Group. “Prevention of neural tube defects: results of the Medical Research Council Vitamin Study.” Lancet, 338(8760) (1991): 131–137.
  21. N eveu, N., Granger, L., St-Michel, P., Lavoie, H.B. “Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction and achievement of pregnancy in 154 women with polycystic ovary syndrome.” Fertil Steril, 87(1) (2007): 113–120.
  22. Qublan, H.S., Yannakoula, E.K., Al-Qudah, M.A., El-Uri, F.I. “Dietary interven¬tion versus metformin to improve the reproductive outcome in women with polycystic ovary syndrome. A prospective comparative study.” Saudi Med J, 28(11) (2007): 1694–1699.
  23. D iabetes in Pregnancy: Management of Diabetes and Its Complications from Preconception to the Postnatal Period. National Collaborating Centre for Women’s and Children’s Health; National Institute for Clinical Excellence. London, England, RCO G Press (2008).
  24. A merican Diabetes Association. Standards of medical care in diabetes – 2011. Diabetes Care, 34(2011) (Suppl 1): 11–61.
  25. King, P. A. “New model for preconception care in women with diabetes.” Journal of Diabetes Nursing, 17(2013): 56–61.
  26. U .S. Preventive Services Task Force. Screening for chlamydial infection: recommendations and rationale. Am J Prev Med, 20(2001) (Suppl 3): 90–94.
  27. U .S. Preventive Services Task Force. Screening for gonorrhea. Ann Fam Med, (3)2005: 263–267.
  28. U .S. Public Health Service Task Force recommendations for the use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States. MMWR Recomm Rep, 51(2002) (RR-18): 1–38.
  29. U .S. Preventive Services Task Force. Screening for syphilis infection. Access [], last accessed 26 Apr 2015.
  30. M ast, E.E., Weinbaum, C.M., Fiore, A.E., et al. “A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (AC IP) part II: immunization of adults.” MMWR Recomm Rep, 55(2006) (RR-16): 1–33.
  31. Fiore, A.E., Uyeki, T.M., Broder, K., et al. “Prevention and control of influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (AC IP), 2010.” MMWR Recomm Rep, 59(2010) (RR-8): 1–62.
  32. Watson, J.C., Hadler, S.C., Dykewicz, C.A., Reef, S., Phillips, L. “Measles, mumps, and rubella – vaccine use and strategies for elimination of measles, rubella, and congenital rubella syndrome and control of mumps: recommendations of the Advisory Committee on Immunization Practices (AC IP).” MMWR Recomm Rep, 47(1998) (RR-8): 1–57.
  33. A dvisory Committee on Immunization Practices (AC IP). Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant women (2012). MMWR Morb Mortal Wkly Rep, 62(7) (2013): 131–135.
  34. M arin, M., Güris, D., Chaves, S.S., Schmid, S., Seward, J.F. “Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (AC IP)”. MMWR Recomm Rep, 56(2007) (RR-4): 1–40.
  35. Lu, M.C. “Recommendations for preconception care.” Am Fam Physician, 76(3) (2007): 397–400.
  36. M umford, S.L., et al. “Preconception care: it’s never too early.” Reproductive Health, 11(2014): 73.
  37. Shishkin, M.A. Individual development and evolutionary theory // Evolution and biocenotic crises. M. Nauka (1987): 76–124.
  38. Markov, A., Naimark, E. Evolution. Classical ideas in the light of new discoveries. Moscow. AST; CORPU S (2014): 656 p.
  39. Lovejoy, D.A. “Systems approaches to genomic and epigenetic interregulation of peptide hormones in stress and reproduction.” Progress in Biophysics and Molecular Biology, 113(3) (2013): 375–386.
  40. N akamura, K., Sheps, P., Arck, P. “Stress and reproductive failure: past notions, present insights and future directions.” J Assist Reprod Genet, 25(2–3) (2008): 47–62.
  41. Lynch, C.D., Sundaram, R., Maisog, J.M., Sweeney, A.M., Buck Louis, G.M. “Preconception stress increases the risk of infertility: results from a couple-based prospective cohort study – the LIFE study.” Hum Reprod, 29(5) (2014): 1067–1075.
  42. Bertram, C., et al. “Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function.” J Physiol – Lond, 586(2008): 2217–2229.
  43. D e Kloet, E.R. Hormones and the stressed brain. Stress: Current Neuroendocrine and Genetic Approaches. Ann N Y Acad Sci, (2004) (Vol 1018): 1–15. Access [], last accessed 26 Apr 2015.
  44. M airesse, J., et al. “Maternal stress alters endocrine function of the feto-placental unit in rats.” Am J Physiol Endocrinol Metab, 292(6) (2007): 1526–1533.
  45. T egethoff, M., et al. “Effects of intrauterine exposure to synthetic glucocorticoids on fetal, newborn, and infant hypothalamic–pituitary–adrenal axis function in humans: a systematic review.” Endocr Rev, 30 (2009): 753–789.
  46. Takiuti, N.H., Kahhale, S., Zugaib, M. “Stress-related preeclampsia: an evolutionary maladaptation in exaggerated stress during pregnancy?” Medical Hypothesis, 60(2003): 328–331.
  47. Yu, Y., Zhang, S., Wang, G., et al. “The combined association of psychosocial stress and chronic hypertension with preeclampsia.” Am J Obstet Gynecol, 209(2013): 1–438.
  48. Zhang, S. “Association Between Mental Stress and Gestational Hypertension/Preeclampsia: A Meta-Analysis.” Obstetrical & Gynecological Survey, 68(2013): 825–834.
  49. C hrousos, G.P. An integrated view of the stress response and stress-related behavioral and/or somatic disorders // Hans Selye Centennial Lecture, Proceedings of the Second World Conference on Stress. Budapest (2007).
  50. C hatterjee, A., Chatterjee, R. “How stress affects female reproduction: An overview.” Biomedical Research, 20(2) (2009): 79–83.
  51. N icolaides, N.C., Galata, Z., Kino, T., Chrousos, G.P., Charmandari, E. “The human glucocorticoid receptor: molecular basis of biologic function.” Steroids, 75(1) (2010): 1–12.
  52. W hirledge, S., Cidlowski, J. “A Role for Glucocorticoids in Stress-Impaired Reproduction: Beyond the Hypothalamus and Pituitary.” Endocrinology, 154(12) (2013): 4450–4468.
  53. M andl, M., Ghaffari-Tabrizi, N., Haas, J., Nöhammer, G., Desoye, G. “Differential glucocorticoid effects on proliferation and invasion of human trophoblast cell lines.” Reproduction, 132(1) (2006): 159–167.
  54. A udette, M.C., Greenwood, S.L., Sibley, C.P., et al. “Dexamethasone stimulates placental system A transport and trophoblast differentiation in term villous explants.” Placenta, 31(2) (2010): 97–105.
  55. R yu, J.S., Majeska, R.J., Ma, Y., LaChapelle, L., Guller, S. “Steroid regulation of human placental integrins: suppression of α2 integrin expression in cytotrophoblasts by glucocorticoids.” Endocrinology, 140(9) (1999): 3904–3908.
  56. Stouffer, R.L., Bishop, C.V., Bogan, R.L., Xu, F., Hennebold, J.D. “Endocrine and local control of the primate corpus luteum.” Review Article. Reproductive Biology, 12(13) (2013): 259–271.
  57. C hrousos, G.P. Neuroendocrinology of stress and female reproductive function. Proceedings of the 5th European Congress of Reproductive Immunology. Berlin (2007).
  58. C hrousos, G.P. “Stress and Disorders of the Stress System.” Nat Rev Endocrinol, 5(2009): 374–381.
  59. Bulavenko, O.V. Luteal phase deficiency: clinical features, diagnosis and treatment: Abstract of dissertation for the PhD on specialty 14.01.01. “Obstetrics and Gynecology” // SI “IPOG of the NAM S of Ukraine”. Kyiv (2008): 37 p.
  60. Tatarchuk, T.F., Kosei, N.V., Tutchenko, T.N. “Treatment of stress-induced luteal phase deficiency.” Reproductive Endocrinology, 2(2011): 34–40.
  61. Tutchenko, T.M. Preconception care for women with stress-induced pregnancy loss history: Abstract of dissertation for the PhD on specialty 14.01.01. “Obstetrics and Gynecology”. SI “IPOG of the NAM S of Ukraine”. Kyiv (2010): 20 p.
  62. Fjorback, L.O., Arendt, M., Ornbøl, E., Fink, P., Walach, H. “Mindfulness-based stress reduction and mindfulnessbased cognitive therapy: a systematic review of randomized controlled trials.” Acta Psychiatrica Scandinavica, 2(2011) (Vol. 124): 102–119.
  63. Vorobyova, O.V., Ryabokon, I.V. “Stress and anti-stress therapy.” Attending Physician, 5(2011): 85–89.



How to Cite

Татарчук, Т. Ф., & Тутченко, Т. Н. (2015). Preconception preparation as a component of family planning services in modern conditions. REPRODUCTIVE ENDOCRINOLOGY, (22), 7–14.



Health care