Pecularities of functional state of antigen-presenting cells of the endometrium in patients with deep infiltrating endometriosis

Authors

  • Н. М. Рожковська Odesa National Medical University, Ukraine
  • О. М. Степановичус Odesa National Medical University, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2015.21.44-46

Keywords:

external genital endometriosis, immunity, antigen-presenting cells

Abstract

The aim of the study was to evaluate the functional state of antigen-presenting endometrial cells in patients with external genital endometriosis.

It is shown that in healthy women in the control group peritoneal fluid contains from 7 to 12 million white blood cells in 3–15 ml, represented mainly by macrophages (90%), lymphocytes (5–10%) and polymorphonuclear leukocytes (up to 5%), whereas in women with external genital endometriosis number of macrophages increased to 95% due to the relative impoverishment of the population of polymorphonuclear leukocytes. The total number of cells in the peritoneal fluid increased to 18–20 million in 1 ml. In patients with external endometriosis in the endometrium the activity of mature dendritic cells reduced (up to 5,2 ± 0,5 cells/mm2 CD23 in the functional layer and to 6,0 ± 0,5 cells/mm2 in the basal layer), and increased activity of immature dendritic cells in the basal layer (CD1a to 34,2 ± 1,2 cells/mm2).

Author Biographies

Н. М. Рожковська, Odesa National Medical University

MD, professor at the Obstetrics and Gynecology Department number 1

О. М. Степановичус, Odesa National Medical University

PhD, assistant at the Obstetrics and Gynecology Department number 1

References

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Published

2015-02-11

How to Cite

Рожковська, Н. М., & Степановичус, О. М. (2015). Pecularities of functional state of antigen-presenting cells of the endometrium in patients with deep infiltrating endometriosis. REPRODUCTIVE ENDOCRINOLOGY, (21), 44–46. https://doi.org/10.18370/2309-4117.2015.21.44-46

Issue

No. 21 (2015)

Section

Gynecology

License

Copyright (c) 2015 Н. М. Рожковська, О. М. Степановичус

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