Pecularities of functional state of antigen-presenting cells of the endometrium in patients with deep infiltrating endometriosis

Н. М. Рожковська, О. М. Степановичус

Abstract


The aim of the study was to evaluate the functional state of antigen-presenting endometrial cells in patients with external genital endometriosis.

It is shown that in healthy women in the control group peritoneal fluid contains from 7 to 12 million white blood cells in 3–15 ml, represented mainly by macrophages (90%), lymphocytes (5–10%) and polymorphonuclear leukocytes (up to 5%), whereas in women with external genital endometriosis number of macrophages increased to 95% due to the relative impoverishment of the population of polymorphonuclear leukocytes. The total number of cells in the peritoneal fluid increased to 18–20 million in 1 ml. In patients with external endometriosis in the endometrium the activity of mature dendritic cells reduced (up to 5,2 ± 0,5 cells/mm2 CD23 in the functional layer and to 6,0 ± 0,5 cells/mm2 in the basal layer), and increased activity of immature dendritic cells in the basal layer (CD1a to 34,2 ± 1,2 cells/mm2).


Keywords


external genital endometriosis; immunity; antigen-presenting cells

References


Schulke, L., Berbic, M., Manconi, F., et al. “Dendritic cell populations in the eutopic and ectopic endometrium of women with endometriosis.” Hum Reprod, 24(7) (2009): 1695-1703.

N ouri, K., Ott, J., Krupitz, B., Huber, J.C., Wenzl, R. “Family incidence of endometriosis in first-, second-, and third-degree relatives: case-control study.” Reprod Biol Endocrinol, 8(2010): 85–91.

T anmahasamut, P., Noothong, S., Sanga-Areekul, N., et al. “Prevalence of endometriosis in women undergoing surgery for benign gynecologic diseases.” J Med Assoc Thai, 97(2) (2014): 147-152.

P encovich, N., Luk, J., Hantisteanu, S., et al. “The development of endometriosis in a murine model is dependent on the presence of dendritic cells.” Reprod Biomed Online, 28(4) (2014): 515-521.

С.І. Георгієвського. — 2008. — Т. 144, Ч. ІІІ. — С. 219–221. Rozhkovska, N.M., Volіanska, A.G., Stepanovychus, O.M. “Infertility factors in the external genital endometriosis.” Proceedings of the Crimean State Medical University named after SI Georgievskiy, 144(III) (2008): 219-221.


GOST Style Citations


1. Schulke, L., Berbic, M., Manconi, F., et al. “Dendritic cell populations in the eutopic and ectopic endometrium of women with endometriosis.” Hum Reprod, 24(7) (2009): 1695-1703.

2. N ouri, K., Ott, J., Krupitz, B., Huber, J.C., Wenzl, R. “Family incidence of endometriosis in first-, second-, and third-degree relatives: case-control study.” Reprod Biol Endocrinol, 8(2010): 85–91.

3. T anmahasamut, P., Noothong, S., Sanga-Areekul, N., et al. “Prevalence of endometriosis in women undergoing surgery for benign gynecologic diseases.” J Med Assoc Thai, 97(2) (2014): 147-152.

4. P encovich, N., Luk, J., Hantisteanu, S., et al. “The development of endometriosis in a murine model is dependent on the presence of dendritic cells.” Reprod Biomed Online, 28(4) (2014): 515-521.

5. Рожковська, Н.М. Фактори неплідності при зовнішньому генітальному ендометріозі / Н.М. Рожковська, А.Г. Волянська, О.М. Степановичус // Труди Кримського державного медичного університету ім. С.І. Георгієвського. — 2008. — Т. 144, Ч. ІІІ. — С. 219–221.





DOI: http://dx.doi.org/10.18370/2309-4117.2015.21.44-46

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)