Резистентний тонкий ендометрій. Що робити?

І. Я. Кожема; Л. О. Михайлишин; У. С. Дорофеєва

doi:10.18370/2309-4117.2014.19.103-107

Authors

І. Я. Кожема Medical Center «Intersono», Lviv, Ukraine
Л. О. Михайлишин Medical Center «Intersono», Lviv, Ukraine
У. С. Дорофеєва Medical Center «Intersono», Lviv, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2014.19.103-107

Keywords:

resistant thin endometrium, fertilization in vitro, growth factors, granulocyte colony stimulating factor, Filstim

Abstract

Clinical study to assess the effi cacy of intrauterine administration of granulocyte colony stimulating factor (G-CSF, a drug Filstim) in patients with a thin

endometrium (< 7 mm), resistant to traditional treatments was performed.

The study included 38 women with endometrium thickness < 7 mm, aged 35 to 46 years who received human chorionic gonadotropin. Women in this group were held all programs fertilization in vitro. Patients were randomized into two groups. 25 women was administrated Filstim, 13 women the standard endometrial preparation was performed using etenilestradiol, pentoxifylline, sildenafi l citrate. Clinical pregnancy was evaluation criteria. The results showed that G-CSF promotes thickening of the endometrium. Pregnancy in the group of Filstim occurred in 8 (32%) women. In the control group only in one (15%) women.

The authors concluded that G-CSF use is a promising new method for solving the problem of resistant thin endometrium. However, further randomized

control studies are needed to confi rm the eff ectiveness of this method

Author Biography

Л. О. Михайлишин, Medical Center «Intersono», Lviv

PhD

References

Снеn M.J., Yang J.H., Peng F.H., Chen Su., Ho H.N., Yang Y.S. «Extended estrogen administration for women with thin endometrium in frozenthawed in – vitro fertilization.» J Assist reprod Genet (2006).
Sher G., Fisch J.D. «Eff ect of vaginal sidenafi l on the outcome of in vitro fertilization after multiple failures attributed to poor endometrial development.» Fertil Steril (2002).
Ledee-Bataille N., Olivennes F., Lefaix J.L., Chaouat G., Frydman R., Delanian S. «Combined treatment by pentoxifi lline and tocopherol for recipient women with a thin endometrium enrolled in an oocyte donation program.» Hum Reprod (2002).
Casper R.F. «Time to pay attention to the endometrium.» Fertil Steril (2011).
Revel A. «Defective endometrial receptivity.» Fertile Steril (2012).
Scarpellini F., Sbracia F. «Use of colonystimulation factor for the treatment of unexplained reccurent miscarriage: a randomized controlled trial.» J Hum Reprod (2009).
Gleicher N., Vidali A., Barad D.H. «Successful treatment of unresponsive thin endometrium.» Fertil Steril (2011).
Wurfel W., Santjohanser C.,Hirv K., Buhl M., Meri O., Laubert I., von Hertwing I., Fiedler K., Krusmann J., Krussman G. «High pregnancy rates with administration of granulocyte colony-stimulation factor in ART-patients with repetitive implantation failure and lacking killer-cell immunoglobulin -like receptors.»J Hum Reprod (2010).
Qublan H., Amarin Z., Al-Qudah M., Diab F., Nawasreh M., Malkawi S., Balawneh M. «Luteal phase support with GnRH – a improves implantation and pregnancy rates in IVF cycles with thin endometrium.» Hum Fertil (Camb) (2008) Jun.
Papanikolaou E.G., Kyrou D., Paggou E., Humaidan P. «Follicular HGH endometrium priming for IVF patiens experiencing resisting thin endometrium.» A proof of concept study. J Assist Reprod Genet (2013).
Gleicher N., Kim A., Michael T., Lee H.J., Shohat-Tai A., Lazzaroni E., Barad D.H. «A pilot cohort study of granulocyte colony -stimulating factor in the treatment of unresponsive thin endometrium resistant standard therapies.» Hum Reprod (2013).
Gargett C.E., Nguyen H.P., Ye L. «Endometrial regeneration and endometrial stem /progenitor cell.» Rev Endocr Metab Disord (2012).
Amui J., Chek J.H., Cohen R. «Successful twin pregnancy in donor oocyte recipient despite a maximum endometrial thickness in the late proliferative phase of 4 mm.» Clin Exp Gynecol (2014).
Jing Zhao,Tian Tian «Use of Granulocyte colony-stimulating factor for the treatment of thin endometrium in experimental rats.» PLoS ONE (2013).
Kunicki M., Lukaszuk K., Woclawek Potocka I.,Liss J., Kulwikowska P., Szczyptanska J. «Evaluation of granulocyte colony -stimulating factor eff ects on treatmentresistant thin endometrium in women undergoing in vitro fertilization.» Biomed Res Int (2014).
Tanaka T., Umesaki N. «Regulation of the cellular subpopulation rations of normal human endometrial stromal cells by macrophage colony-stimulating factor.» J Mol Med (2003).
Takasaki A., Ohba T., Okamura Y., Honda R., Seki M., Tanaka N. «Clinical use of colony-stimulating Factor-1 in ovulation induction in poor responders.» Fertil Sterillit (2008).