Vitamin D: potential clinical decisions in doctor practice
Keywords:vitamin D3, anti-Mullerian hormone, pregnancy, fertility, polycystic ovary syndrome
It is proved that vitamin D plays a role in the prevention and treatment of many diseases such as immunodeficiency status, anemia, diabetes melitus, various pathological conditions of the liver, gastrointestinal tract, cardiovascular system, tuberculosis, tumors of breast, bowel, etc. Also it was found that vitamin D modulates reproductive processes in women particularly affects steroidogenesis of estradiol and progesterone, and anti-Mullerian hormone in healthy women.
Therefore, at examining patient clinicians should determine the expediency of laboratory assays of the level of vitamin D.
According to the recommendation of the European Society of Endocrinology (2011) vitamin D deficiency is established at blood levels of its active metabolite 25(OH)D less than 20 ng/mL (< 50 nmol/l), failure –21–29 ng/ml (50–75 nmol/l).
- Povoroznyuk, V.V. “State of the problem of osteoporosis and other metabolic bone diseases in Ukraine.” News of Medicine and Pharmacy, 3(487) (2014): 10-13.
- Schwartz, G.J. Vitamin D and D-hormone. M: Anacharsis (2005): 152 p.
- Corbett, S.T., Hill, O., Nangia, A.K. “Vitamin D receptor found in human sperm.” Urol, 68(2006):1345-9.
- Lerchbaum, E., Obermayer-Pietsch, B. “MECHANISMS IN ENDOCRINOLOGY: Vitamin D and fertility: a systematic review.” Eur J Endocrinol, 166(2012): 765-778. May 1.
- Yamamoto, H., et al. “The caudal-related homeo-domain protein Cdx-2 regulates vitamin D receptor gene expression in the small intestine.” J. Bone Miner. Res, 14(2) (1999): 240-247.
- Lee, D.M.1, Tajar, A., Pye, S.R., Boonen; “EMAS study group. Association of hypogonadism with vitamin D status: the European Male Ageing Study.” Eur J Endocrinol, 166(1) (2012):77-85. Jan. DOI: 10.1530/EJE-11-0743. Epub 2011 Nov 2.
- Clarks, M. et al. “1,25-dihydroxyvitamin D3 target cells in immature pancreatic islets.“ Amer. J. Physiol, 253(1) Pt. 1(1987): E99-E105.
- Blomberg Jensen, M., Nielsen, J.E., Jorgensen, A., et al. “Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract.” Hum Reprod, 25(2010): 1303-11.
- Haussler, M.R. “Vitamin D receptors: nature and functuion.” Ann. Rev. Nutrition, 6(1986): 525-562.
- Isia, G., et al. “High prevalence of hypovitaminosis D in female type 2 diabetic population.” Diabetes care, 24(8) (2001): 1496.
- Lukyanova, E.M., Antypkin, Y.G., Omelchenko, L.I., Apuhovskaya, L.I. Vitamin D and its role in the health of children and pregnant women. K.: Aurora-print (2005): 229 p.
- Clinical Guidelines Authorized by: OGCCU King Edward Memorial Hospital Review Team: OGCCU Perth Western Australia Screening for and Treatment of Vitamin D Deficiency in Pregnancy Date Revised (2014). April.
- Yildizhau, R., Kurdolgu, M. “Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome.” Archives of
- Gynecology and obstetrics, 280(2009):559-563.
- Pittas, Ag., Lan, J., Dawson-Hughes, B. “The rolef vitamin D and calcium in type 2 diabets. A systematic review and meta-analysis.” Journal of Clinical Endocrinology and Metabolism, 92(2007):2017-2029.
- Absatarova, Y.S., Andreeva, E.N. “The role of vitamin D and melatonin in the pathogenesis of polycystic ovary syndrome.” Obesity and Metabolism, 1(2014).
- Holick, M.F., Binkley, N.C., Heike, A., et al. “Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline.” J Clin Endocrinol Metab, 96(7) (2011):1911-30.
How to Cite
Copyright (c) 2015 Ю. І. Комісаренко, М. І. Бобрик, І. В. Сідорова, О. А. Бурка
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.