Innervation apparatus and neuro-tissue relations in the myometrium of patients with adenomyosis


  • M. R. Orazov Research Institute of Medical Family Problems, Donetsk National Medical University named after Maxim Gorky,
  • O. M. Nosenko University Hospital «Center of Reconstructive and Restorative Medicine», Odessa National Medical University, Ukraine



adenomyosis, chronic pelvic pain, myometrium, innervation apparatus, neyro-tissue relationship, neurofilaments


The aim of the present work was the immunohistochemical assessment of innervation apparatus and neuro-tissue relationship in the 60 uterus, which received after hysterectomy from patients with diffuse adenomyosis II–III degree, accompanied by severe pain. Visualization of nerve fibers was performed using mAb to neurofilament proteins. Based on these results the authors conclude that the main carrier of the nerves in the uterus and a potential cause of the formation of hyperalgesia at adenomyosis is myometrium with the formation of abnormally excessive innervation apparatus around foci of ectopic endometrium, in perivascular regions and in the stroma between the bundles of smooth muscle cells

Author Biographies

M. R. Orazov, Research Institute of Medical Family Problems, Donetsk National Medical University named after Maxim Gorky


O. M. Nosenko, University Hospital «Center of Reconstructive and Restorative Medicine», Odessa National Medical University

MD, Professor, doctor of Surgical Department with Minimally Invasive Methods of Diagnosis and Treatment


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Tumors and pretumoral pathology