DOI: https://doi.org/10.18370/2309-4117.2014.20.79-84

Innervation apparatus and neuro-tissue relations in the myometrium of patients with adenomyosis

M. R. Orazov, O. M. Nosenko

Abstract


The aim of the present work was the immunohistochemical assessment of innervation apparatus and neuro-tissue relationship in the 60 uterus, which received after hysterectomy from patients with diffuse adenomyosis II–III degree, accompanied by severe pain. Visualization of nerve fibers was performed using mAb to neurofilament proteins. Based on these results the authors conclude that the main carrier of the nerves in the uterus and a potential cause of the formation of hyperalgesia at adenomyosis is myometrium with the formation of abnormally excessive innervation apparatus around foci of ectopic endometrium, in perivascular regions and in the stroma between the bundles of smooth muscle cells


Keywords


adenomyosis; chronic pelvic pain; myometrium; innervation apparatus; neyro-tissue relationship; neurofilaments

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References


Al-Fozan, H., Bakare, S., Chen, M.F., Tulandi,T. “Nerve fibers in ovarian dermoid cysts and endometriomas.” Fertil Steril, 82(2004): 230-31.

Anaf, V., Simon, P., ElNakadi, I., Fayt, I., Buxant, F.,Simonart, T., Peny, M.O., Noel, J.C. “Relationship between endometriotic foci and nerves in rectovaginal endometriotic nodules.” Hum Reprod, 15(2000): 1744-1750.

Berkley, K.J., Rapkin, A.J., Papka, R.E. “The pains of endometriosis.” Science, 308(2005): 1587-89.

Berkley, K.J., Dmitrieva, N., Curtis, K.S., Papka, R.E. “Innervation of ectopic endometrium in a rat model of endometriosis.” Proc Natl Acad Sci USA, 101(2004): 11094-98.

Cetin, C., Serdaroglu, H., Tuzlali, S. “The importance of endometrial nerve fibers and macrophage cell count in the diagnosis of endometriosis.” Iran J Reprod Med., 11(5) (2013): 405-14.

Cheng, J.K., Ji, R.R. “Intracellular signaling in primary sensory neurons and persistent pain.” Neurochem Res., 33(2008): 1970-78.

Li, Y., Zhang, S.F., Zou, S.E., Xia, X., Bao, L. “Accumulation of nerve growth factor and its receptors in the uterus and dorsal root ganglia in a mouse model of adenomyosis.” Reprod Biol Endocrinol, 8,9 (2011): 30. doi: 10.1186/1477-7827-9-30.

Mendell, L.M., Albers, K.M., Davis, B.M. “Neurotrophins, nociceptors, and pain.” Microsc Res Tech., 45(1999): 252-61.

Quinn, M. “Uterine innervation in adenomyosis.” J Obstet Gynaecol., 27(3) (2007): 287-91.

Ramer, M.S., Bisby, M.A. “Adrenergic innervation of rat sensory ganglia following proximal or distal painful sciatic neuropathy: distinct mechanisms revealed by anti-NGF treatment.” Eur J Neurosci, 11(1999): 837-46.

Triolo, O., Laganà, A.S., Sturlese, E. “Chronic pelvic pain in endometriosis: an overview.” J Clin Med Res., 5(3) (2013): 153-63. doi: 10.4021/jocmr1288w.16

Tulandi, T., Felemban, A., Chen, M.F. “Nerve fibers and histopathology of endometriosis-harboring peritoneum.” J Am Assoc Gynecol Laparosc, 8(2001): 95-8.

Vercellini, P., Somigliana, E., Viganò, P., Abbiati, A., Barbara, G., Fedele, L. “Chronic pelvic pain in women: etiology, pathogenesis and diagnostic approach.” Gynecol Endocrinol., 25(3) (2009): 149-58. doi: 10.1080/09513590802549858.

Wang, G., Tokushige, N., Markham, R., Fraser, I.S. “Rich innervation of deep infiltrating endometriosis.” Hum Reprod., 24(2009): 827-34.

Woolf, C.J. “Phenotypic modification of primary sensory neurons: the role of nerve growth factor in the production of persistent pain.” Philos Trans R Soc Lond B Biol Sci, 351(1996): 441-48.


GOST Style Citations


1. Al-Fozan, H., Bakare, S., Chen, M.F., Tulandi,T. “Nerve fibers in ovarian dermoid cysts and endometriomas.” Fertil Steril, 82(2004): 230-31.

2. Anaf, V., Simon, P., ElNakadi, I., Fayt, I., Buxant, F.,Simonart, T., Peny, M.O., Noel, J.C. “Relationship between endometriotic foci and nerves in rectovaginal endometriotic nodules.” Hum Reprod, 15(2000): 1744-1750.

3. Berkley, K.J., Rapkin, A.J., Papka, R.E. “The pains of endometriosis.” Science, 308(2005): 1587-89.

4. Berkley, K.J., Dmitrieva, N., Curtis, K.S., Papka, R.E. “Innervation of ectopic endometrium in a rat model of endometriosis.” Proc Natl Acad Sci USA, 101(2004): 11094-98.

5. Cetin, C., Serdaroglu, H., Tuzlali, S. “The importance of endometrial nerve fibers and macrophage cell count in the diagnosis of endometriosis.” Iran J Reprod Med., 11(5) (2013): 405-14.

6. Cheng, J.K., Ji, R.R. “Intracellular signaling in primary sensory neurons and persistent pain.” Neurochem Res., 33(2008): 1970-78.

7. Li, Y., Zhang, S.F., Zou, S.E., Xia, X., Bao, L. “Accumulation of nerve growth factor and its receptors in the uterus and dorsal root ganglia in a mouse model of adenomyosis.” Reprod Biol Endocrinol, 8,9 (2011): 30. doi: 10.1186/1477-7827-9-30.

8. Mendell, L.M., Albers, K.M., Davis, B.M. “Neurotrophins, nociceptors, and pain.” Microsc Res Tech., 45(1999): 252-61.

9. Quinn, M. “Uterine innervation in adenomyosis.” J Obstet Gynaecol., 27(3) (2007): 287-91.

10. Ramer, M.S., Bisby, M.A. “Adrenergic innervation of rat sensory ganglia following proximal or distal painful sciatic neuropathy: distinct mechanisms revealed by anti-NGF treatment.” Eur J Neurosci, 11(1999): 837-46.

11. Triolo, O., Laganà, A.S., Sturlese, E. “Chronic pelvic pain in endometriosis: an overview.” J Clin Med Res., 5(3) (2013): 153-63. doi: 10.4021/jocmr1288w.16

12. Tulandi, T., Felemban, A., Chen, M.F. “Nerve fibers and histopathology of endometriosis-harboring peritoneum.” J Am Assoc Gynecol Laparosc, 8(2001): 95-8.

13. Vercellini, P., Somigliana, E., Viganò, P., Abbiati, A., Barbara, G., Fedele, L. “Chronic pelvic pain in women: etiology, pathogenesis and diagnostic approach.” Gynecol Endocrinol., 25(3) (2009): 149-58. doi: 10.1080/09513590802549858.

14. Wang, G., Tokushige, N., Markham, R., Fraser, I.S. “Rich innervation of deep infiltrating endometriosis.” Hum Reprod., 24(2009): 827-34.

15. Woolf, C.J. “Phenotypic modification of primary sensory neurons: the role of nerve growth factor in the production of persistent pain.” Philos Trans R Soc Lond B Biol Sci, 351(1996): 441-48.





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ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)