New era in treatment of uterine fibroids in women of different age groups


  • Т. Ф Татарчук Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine, Ukraine
  • Н. В. Косей Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine, Ukraine
  • Т. Н. Тутченко Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine, Ukraine
  • В. О. Джупин Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine, Ukraine



uterine fibroids, selective progesterone receptor modulators, ulipristal acetate


Despite the high level of development of modern surgery and pharmacology, none of surgical procedures (hysterectomy/myomectomy or uterine artery embolization) or the drug does not guarantee the absence of recurrence of uterine fibroids in the future. However, there are quite effective methods of pharmacotherapy its manifestations. In particular, selective progesterone receptor modulators show high effectiveness against the symptoms of fibroids and sizes nodes, which allows us to consider them as a full fledged alternative to surgical treatment of uterine fibroids.
The results of PEARL-I, -II, -III studies show that the use of such a selective progesterone receptor modulator as ulipristal acetate in treating symptomatic uterine fibroids is safe and well tolerated, leading to rapid cupping uterine bleeding nodes, greatly reduces the size and the therapeutic effect is maintained even after therapy discontinuation.

Author Biographies

Т. Ф Татарчук, Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine

MD, professor, corresponding member. NAMS of Ukraine, Deputy Director for Research, Head of Endocrine Gynecology

Н. В. Косей, Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine

MD, chief researcher at the Department of Endocrine Gynecology

Т. Н. Тутченко, Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine

PhD, scientific researcher, Department of Endocrine Gynecology


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How to Cite

Татарчук, Т. Ф., Косей, Н. В., Тутченко, Т. Н., & Джупин, В. О. (2014). New era in treatment of uterine fibroids in women of different age groups. REPRODUCTIVE ENDOCRINOLOGY, (20), 9–20.



Scientific Studies