Menstrual dysfunction in women with metabolic syndrome


  • Н. Ю. Педаченко Shupyk National Medical Academy of Postgraduate Education, Ukraine



metabolic syndrome, menstrual dysfunction, polycystic ovary syndrome, luteal phase defficiency, Tazalok™


The results of the study features the reproductive health of women with metabolic syndrome (MS). It is established that MS is characterized by high incidence of polycystic ovary syndrome (PCOS), anovulation, luteal phase defect in ovulatory PCOS, accompanied by infertility, and high levels of hormone dependent hyperproliferative pathologies of the endometrium and breast. It is proved that the application of lifestyle modification program with the addition of multicomponent herbal preparation Tazalok™ results in a substantial restoration of natural ovulatory cycles and normalization of the endometrium hystology in luteal phase in women with MS than in terms of the lifestyle modification program alone without metabolic phytocorrection.

Author Biography

Н. Ю. Педаченко, Shupyk National Medical Academy of Postgraduate Education

MD, Dr. Sci., Assistant of Professor of Obstetrics, Gynecology and Perinatology Department


  1. Aliyeva N.A. «Features of the reproductive health of adolescent girls with obesity different genesis.» Author’s thesis for the degree of candidate of medical sciences. Volgograd, (2007):18.
  2. Bulavenko. O.V. «Luteal phase deficiency: clinical features, diagnosis and treatment.» Author’s thesis for the degree of doctor of medical sciences. Kyiv, (2008):3.
  3. Butrova S.A. «Metabolic syndrome: pathogenesis, clinical features, diagnosis, treatment approaches.» Russian Medical Journal, 9 (2) (2001):56-62.
  4. Ginsburg M.M., Kryukov N.N. «Obesity. Effect on the development of metabolic syndrome. Prevention and treatment.» M. Medpractice-M., (2002):127.
  5. Manukhin I.B., Gevorgyan M.A. et al. «Metabolic disorders in women with polycystic ovary syndrome.» Problems of Reproduction. 4(1999):7-13.
  6. Pedachenko (Voronenko) N.Y. «Adypokine resistin and lipokalin-2 and their role in the pathogenesis of polycystic ovary syndrome and metabolic syndrome.» Medical Perspectives, XVIII(3) (2013):95-111.
  7. Pedachenko (Voronenko) N.Y. «Biological effects of adipokines and their system against the background of the relationship of obesity as a major component of the metabolic syndrome.» Medicine: scientific and practical peer-reviewed journal, 3 (82) (2013):35-42.
  8. Voronenko (Pedachenko) N.Y. «Impact of overweight on the development of hyperplastic processes of the endometrium in women of late reproductive age.» Women’s Health, 10 (56) (2010):127-129.
  9. Pedachenko (Voronenko) N.Y.«Hormone of adipose tissue adiponectin and its biological role in healthy women of reproductive age and patients with metabolic syndrome.» // Ukrainian Medical Journal, 4 (96) (2013):142-145
  10. Pedachenko (Voronenko) N.Y.«Adipose tissue dysfunction in the formation of metabolic syndrome.» Women’s Health, 5(2013):65-71.
  11. Pedachenko (Voronenko) N.Y.«Clinical characteristics of women of reproductive age with metabolic syndrome.» Medicine: Scientific-Practical Refereed Journal, 4 (83) (2013):37-46.
  12. Pedachenko (Voronenko) N.Y. «Reproductive system in metabolic syndrome.» Women’s Health, 8 (54) (2010):136-139.
  13. Tatarchuk T.F., Voronenko N.Y., Hominskaya Z.B., Kapshuk І.N., Tonkovid O.B. «Benign breast disease and metabolic syndrome.» Modern medicine: current issues. Novosibirsk: «SibAK», (2013):6-23.
  14. Tatarchuk T.F., Voronenko N.Y., Kossey N.V., Ganji I.Y., Kapshuk I.M. «Pathogenetic aspects of reproductive health in the metabolic syndrome in women.» Women’s Health, 6 (62) (2011):155-160.
  15. Abdullayev R.Y., Vdovichenko Y.P., Voronenko (Pedachenko) N.Y., Muchomor A.I., Fedko A.A. «Ultrasound diagnosis in reproductive gynecology.» Practice Manual. Kharkiv: New word, (2013):147 р.
  16. Balkau B., Charles M.A. «Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR).» Diab Med, 16(1999):4242-443.
  17. Björntorp P. «Abdominal obesity and the metabolic syndrome.» Ann Med, 24(1992):465-468.
  18. Bohler H.Jr., Mokshagundam S., Winters S.J.«Adipose tissue and reproduction in women.» Fertil Steril, 94(2010):795-825.
  19. Clark A.M., Thornley B., Tomlinson L., Galletley C., Norman R.J. «Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment.» Hum Reprod, 13(1998):1502-1505.
  20. Fain J.N., Madan A.K., Hiler M.L., Cheema P., Bahouth S.W. «Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans.» Endocrinology, 145(2004):2273-2282.
  21. «Group REA-SPcw Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome (PCOS).» Hum Reprod, 19(2004):41-47.
  22. Kershaw E.E., Flier J.S. «Adipose tissue as an endocrine organ.» J Clin Endocrinol Metab, 89(2004):2548-2556.
  23. Kuk J.L., Church T.S., Blair S.N., Ross R. «Measurement site and the association between visceral and abdominal subcutaneous adipose tissue with metabolic risk in women» Obesity (Silver Spring), 18(2010):1336-1340.
  24. Lemoine S., Rossell N., Drapeau V., Poulain M., Garnier S., Sanguignol F., Mauriege P. «Effect of weight reduction on quality of life and eating behaviors in obese women.» Menopause, 14(2007):432-440.
  25. Mutsaerts M.A., Groen H., ter Bogt N.C., Bolster J.H., Land J.A., Bemelmans W.J., Kuchenbecker W.K., Hompes P.G., Macklon N.S., Stolk R.P. et al.«The LIFESTYLE study: costs and effects of a structured lifestyle program in overweight and obese subfertile women to reduce the need for fertility treatment and improve reproductive outcome. A randomised controlled trial.» BMC Womens Health, 10(2010):22.
  26. «Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group: Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril, 81(2004):19-25.
  27. Shah D., Nagarajan N. «Luteal insufficiency in first trimester.» Indian J Endocrinol Metab, 17 (1) (2013):44-49.
  28. Sarcar F.H., Adsule S., Padhye S. et al. Mini Rev. Med. Chem, 6 (2006):401-407.
  29. Reznikov O.G., Tarasenko L.V. «Pharmacology and drug toxicology.», 6 (25) (2011):30-34.



How to Cite

Педаченко, Н. Ю. (2014). Menstrual dysfunction in women with metabolic syndrome. REPRODUCTIVE ENDOCRINOLOGY, (18), 106–114.



Clinical study