Preeclampsia: modern laboratory capabilities for the prognosis of the risk of this complication in the first trimester
Keywords:preeclampsia, risk markers, placental growth factor
Preeclampsia is a pathological syndrome that develops during pregnancy and complicates 3–5% of all pregnancies, being one of the main causes of premature birth, maternal and perinatal mortality.
Fetal Medicine Foundation recommended to assess the risk of developing preeclampsia used in the first trimester of a comprehensive assessment, including data about the pregnant woman, the presence of clinical risk factors, ultrasound features, data on the level of blood pressure, as well as level of two biochemical markers: placental growth factor (PlGF) and plasma protein A, associated with pregnancy (PAPP-A) that significantly reduced when there is a high risk of preeclampsia. This assessment allows predicting the development of early preeclampsia in 90% of cases, the level of false-positive results in 5% of cases and should be performed in all pregnant women in the first trimester in terms of 11–13 weeks.
- Poon L.C., Nicolaides K.H. «Early prediction of preeclampsia.» Obstetrics and Gynecology International (2014).
- WHO «Recommendations for Prevention and Treatment of Pre-eclampsia and Eclampsia.» (2014) (http://whqlibdoc.who.int/publications/2011/9789241548335_eng.pdf).
- Akolekar R., Syngelaki A., Poon L., Wright D., Nicolaides K.H. «Competing risks model in early screening for preeclampsia by biophysical and biochemical markers.» Fetal Diagn Ther, 33(2013):8-15.
- Poon L.C., Syngelaki A., Akolekar R., Lai J., Nicolaides K.H. «Combined screening for preeclampsia and small for gestational age at 11–13 weeks.» Fetal Diagn Ther, 33(2013):16-27.
- Lai J., Pinas A., Poon L.C., Agathokleous M., Nicolaides K.H.«Maternal serum placental growth factor, pregnancy-associated plasma protein-A and free β-human chorionic gonadotrophin at 30–33 weeks in the prediction of pre-eclampsia.» Fetal Diagn Ther, 33(2013):164-72
How to Cite
Copyright (c) 2014 О. В. Рыкова
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.