Efficiency of tivortin in pregnant with heart failure

А. Ю. Ліманська, Ю. В. Давидова, В. А. Слободський, Л. П. Бутенко

Abstract


The study on the participation of 40 pregnant women with heart failure degree II-III according to NYHA classification on a background of cardiovascular disease (congenital heart disease, hypertension) who received standard therapy of heart failure was performed. All pregnant women were divided into 2 groups of 20 pregnant women in each group. In the main group, which included women with low levels of vascular endothelial growth factor (VEGF) in the first trimester of gestation (indicates a disturbance of the endothelial function), to the basic treatment of heart failure received supplemental arginine hydrochloride (drug Tivortin). The drug was administered by intravenous injection 4,2% 100 ml for 5 days followed by oral solution 5 ml 3-4 times a day, 10 days in the hospital
and continue for 3-4 weeks during the stay at home. Women in the comparison group continued to receive standard therapy.
The results showed that the addition Tivortin to the basic treatment of pregnant women with heart failure improve quality of life, improve overall health, increase exercise tolerance, increased glomerular filtration rate, reduce the rate of vasoconstrictor endothelin. This significantly improves the results of treatment of heart failure during pregnancy.


Keywords


heart failure; pregnancy; vascular endothelium; nitric oxide; L-arginine; Tivortin

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GOST Style Citations


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DOI: http://dx.doi.org/10.18370/2309-4117.2014.18.66-70

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ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)