Improved therapeutic management of women with endometriosis

Т. Ф Татарчук, Н. Ф. Захаренко, І. П. Маноляк, В. П. Ковбасій

Abstract


It was developed and tested a complex drug therapy of women with endometriosis. Within 6 months of the study’s authors are actively watching the 80 women with adenomyosis, which were divided into two groups. The first group of women (n = 42) administered progestin therapy for 6 months – Vissane (dienogest 2 mg). The second group included 38 patients treated with combined therapy: Vissane (dienogest 2 mg) daily for 6 months, Adaptol (mebicar 500 mg) twice a day and Noophen (phenibutum 250 mg) twice a day for three months.

The results showed a slightly higher clinical efficacy of progestogen therapy (Visan) in combination with non-hormonal drugs (Adptol and Noophen).


Keywords


endometriosis; adenomyosis; integral indicator of pathology; Vissane; Adaptol; Noophen

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GOST Style Citations


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Al-Jefout M., Dezarnaulds G., Cooper M., Tokushige N. et al. «Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double blind study.» Hum Reprod, 24(12)(2009):3019-3024.

Okada H. et al. «The inhibitory effect of dienogest, a synthetic steroid, on the growth of human endometrial stromal cells in vitro.» Mol Hum Reprod,4(7)(2001):341-347.

Sasagawa S., Shimizu Y., Kami H. et al. «Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile.» Steroids, 73(2008): 222-23.

Shimizu Y. et al. «Dienogest, a synthetic progestin, inhibits the proliferation of immortalized human endometrial epithelial cells with suppression of cyclin D1 gene expression.»  Mol Hum Reprod,10(15)(2009):693-701.

Tatsum H.i., Kitawaki J.i., Tanaka K.i., Hosoda T., Honjo H. «Lack of stimulatory effect of dienogest on the expression of intercellular adhesion molecule – 1 and vascular cell adhesion molecule – 1 by endothelial cell as compared with other sytetic progestins.» Maturitas, 42(2002):287-94.

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DOI: http://dx.doi.org/10.18370/2309-4117.2014.18.24-27

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ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)