Role of oxidative stress in genesis of endometriosis

Authors

  • Н. Ф. Захаренко Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine, Ukraine
  • Т. Ф. Татарчук Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine, Ukraine
  • Н. В. Коваленко Clinical City Hospital number 9, Kiev, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2014.18.13-16

Keywords:

endometriosis, oxidative stress, lipid peroxidation, ferric iron, Maltofer

Abstract

A comparison of frequencies of allelic variants of genes GSTM1, GSTT1, CYP2D6 in women with endometriosis (139 women) and healthy women (192 women in the control group) was made, and the state of lipid peroxidation in women studied groups was study.
The results showed that activity of lipid peroxidation higher in women with endometriosis, regardless of the site of endometriotic lesions, compared with the control group of healthy women. This demonstrates the importance of oxidative stress in the endometriosis formation.
Also, the results of research suggest that one way of leveling oxidative stress in women with endometriosis can be used of ferric drugs (Maltofer), due to the peculiarities of their digestion and minimize the risk of oxidative stress worsening.

Author Biographies

Н. Ф. Захаренко, Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine

MD, chief researcher at the Endocrine Gynecology Department

Т. Ф. Татарчук, Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine

MD, professor, corresponding member of the NAMS of Ukraine, Deputy Director for Research Work, Head of the Endocrine Gynecology Department

Н. В. Коваленко, Clinical City Hospital number 9, Kiev

Doctor of the Gynecological Department

References

Ivashchenko T.E., Swed N.Y., Bespalova O.N. et al. «Genetic basis of susceptibility to obstetrical and gynecological pathology.» Molecular Medicine, 3(2007):19-26.

Horovenko N.G., Podolskaya S. «The role of genetically determined changes of detoxification system in the development of pathological conditions.» Collected Works of employees of the NMAPE named after P.L. Shupyk, 19(Book 3) (2010):88-94.

Kramareva N.L. «Role of components of the immune system and genetic factors in the pathogenesis and treatment of external genital endometriosis.» Author’s abstract ... thesis for a PhD. St. Petersburg, (2002): 24 p.

Levkovych N.M., Rossokha S.I., Horovenko N.G. «Analysis of the frequency of allelic variant * 4 gene CУР2D6 in population of Ukraine.» Collected Works of employees of the NMAPE named after P.L. Shupyk, 19(Book 3) (2010):224-234.

Kulinskiy V.I., Kolesnichenko L.S. «Glutathione system I. Synthesis, transpоrt, glutathione, glutathione peroxidase.» Biomedical Chemistry, 55(3) (2009):255-277.

Kurashvili V.A., Maylem L. «New in preventing of the oxidative stress.» Journal of Natural Medicine, 1(2001):91-142.

Nagornaya N.V., Chetverik N.A. «Oxidative stress: effects on the human body, evaluation methods.» Contemporary Pediatrics, 2(2010):89-93.

Arand M., Muhlbauer R., Hengstler J., Jager E., Fuchs J., Winkler L., Oesch F.A. «A Multiplex Polymerase Chain Reaction Protocol for the Simultaneous Analysis of the Glutathione S-Transferase GSTM11 and GSTT1 Polymorphisms.» Analytical Biochemistry, 236(1996):184-186.

Borghese B., Vaiman D., de Ziegler D. et al. «Endometriosis and genetics: what responsibility for the genes?» J. Gynecol. Obstet. Biol. Reprod, 39(3) (2010):196-207

Fauconnier A., Chapron C., Dubuisson J.B., Vieira M., Dousset B., Breart G. «Relation between pain symptoms and the anatomic location of deep infiltrating endometriosis.», 78(4) (2002):719-726.

Dun E.C., Taylor R.N., Wieser F. «Advances in the genetics of endometriosis.» Genome Med, 2(10) (2010):75.

Gupta S. et al. «Role of oxidative stress in endometriosis.» Reproduktive BioMedicine Online, 13(1) (2006):126-134.

Garte S., Gaspari L., Alexandrie А.К. et al. «Metabolic gene polymorphism frequencies in control population.» Cancer Epidemiol. Biomarkers Prev, 10(2001):1239-1248.

Geisser P. «Iron Terapy with Special Emphasis on Oxidative Stress.» Dtsch.med.Wschr, 121(1996):1301-1302.

Stefansson H., Geirsson R.T., Steinthorsdottir V. et al. «Genetic factors contribute to the risk of developing endometriosis.» Hum. Reprod, 17(2002):555-559.

Tempfer C.B., Simoni М., Destenaves В., Fauser B.C. «Functional genetic polymorphisms and female reproductive disorders: part II –endometriosis.» Hum Reprod Update, 15(1) (2009):97-118.

Zhou S.F. «Polymorphism of human Cytochrome P450 2D6 and its clinical significance: Part I.» Clin. Pharmacogenet, 48(11) (2009):689-732.

Published

2014-11-17

Issue

Section

Scientific Studies

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