Analysis of histology and expression of sex hormone receptors er and pr in the ovaries at polycystic ovary syndrome

В. М. Запорожан, Н. Н. Рожковская, Ю. В. Онищенко

Abstract


Histologic analysis of ovarian tissue at polycystic ovary syndrome (PCOS) identified specific markers that are pathogenic factors in the case of chronic anovulation. Immunohistochemical research of expression sex hormones receptors in the ovarian tissue in PCOS showed characteristic changes of the expression of estrogen (ER) and progesterone receptors (PR) in the stroma and follicles There was revealed that changes of the expression of sex hormones in the follicles and ovarian stroma can play the important role in the process of folliculogenesis and fertility for women with PCOS.


Keywords


polycystic ovary syndrome; infertility; estrogen and progesterone receptors; immunohistochemistry

References


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GOST Style Citations


Dewailly D. «Definition of polycystic ovary syndrome.» Hum Fertil Camb, 3(2000):73-76

Шепелькевич А.П. Эндокринология. Современные подходы к диагностике и лечению синдрома поликистозных яичников // ARS MEDICA. – 2012. – № 15(70). – С. 98–105.

López E. et al. «Ovulation induction in women with polycystic ovary syndrome: randomized trial of clomiphene citrate versus low-dose recombinant FSH as first line therapy.» Reprod. Biomed. Online. Reproductive Healthcare Ltd, Duck End Farm, Dry Drayton, Cambridge CB23 8DB, UK, 9(4) (2004):382-390.

Burgers J. et al. «Oligoovulatory and anovulatory cycles in women with polycystic ovary syndrome (PCOS): what’s the difference?» J. Clin. Endocrinol. Metab, 95(12) (2010):E485-9.

Li Y., Wei L.-N., Liang X.-Y. «Follicle-stimulating hormone suppressed excessive production of antimullerian hormone caused by abnormally enhanced promoter activity in polycystic ovary syndrome granulosa cells.» Fertil. Steril. Elsevier, 95(7) (2011):2354-8, 2358.e1.

Quezada S. et al. «Evaluation of steroid receptors, coregulators, and molecules associated with uterine receptivity in secretory endometria from untreated women with polycystic ovary syndrome.» Fertil. Steril. Elsevier, 85(4) (2006):1017-1026.

Lessey B.A. et al. «Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women.» Reprod. Biol. Endocrinol, 4 (Suppl, № Supp (1) (2006): 59.

Наказ МОЗ України № 676 від 31 грудня 2004 року «Про затвердження клінічних протоколів з акушерської та гінекологічної кровотечі» м. Київ: МОЗ України. – 2004. – С. – 148. Режим доступа: http://www.moz.gov.ua/ua/print/dn_20131128_0.html

Методология и технология современного анализа данных на STATISTICA. Электронный ресурс. Режим доступа: http://www.statsoft.ru/academy/courses/general/detail.php?ELEMENT_ID=799





DOI: http://dx.doi.org/10.18370/2309-4117.2014.18.9-12

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ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)