Современный менеджмент аномальных маточных кровотечений

Т. Ф Татарчук; О. А. Ефименко; Т. В. Шевчук

doi:10.18370/2309-4117.2013.12.18-28

Authors

Т. Ф Татарчук Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine, Ukraine
О. А. Ефименко Institute of Pediatrics, Obstetrics and Gynecology NAMS of Ukraine, Ukraine
Т. В. Шевчук Institute of Pediatrics, Obstetrics and Gynecology NAMS of Ukraine, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2013.12.18-28

Keywords:

abnormal uterine bleeding, menstrual cycle, tranexamic acid

Abstract

Conducted studies showed that Tranexam is eff ective in the treatment and prevention of abnormal uterine bleeding (AUB) in the background insuffi cient luteal phase of the menstrual cycle in patients of reproductive age with intolerance progestogens syndrome. Prophylactic uses of antifi brinolytic drugs from the fi rst day of the menstrual cycle in women with AUB reduce blood loss, stabilize the menstrual function and also signifi cantly improves the psycho-emotional state of patients.
Diff erentiated approach to the treatment of the AUB and adequate antirecurrent treatment contributes to the stabilization of subjective and objective characteristics of the menstrual cycle, red blood parameters and sonographic endometrial pattern. Pathogenic therapy of AUB allow to avoid a large surgery and associated risks, enables to realize reproduction plans, signifi cantly improves the quality of life.

Author Biographies

Т. Ф Татарчук, Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine

MD, professor, corresponding member. NAMS of Ukraine, Deputy Director for Research, Head of Endocrine Gynecology

О. А. Ефименко, Institute of Pediatrics, Obstetrics and Gynecology NAMS of Ukraine

PhD, senior researcher of the Endocrine Gynecology Department

Т. В. Шевчук, Institute of Pediatrics, Obstetrics and Gynecology NAMS of Ukraine

PhD, senior researcher of the Endocrine Gynecology Department

References

Arthur J Castelbaum. – Luteal phase defect / J.Arthur // The endometrium, London, 2002. – 675 p.
B. de Ligniers Endometrial eff ect of progesterone versus progestins, The Menopause at the Millenium / B. de Ligniers. London- New York – 2000 – 720 p.
Cochran Database of Systematic Reviews 2009 Issue 2. http://search.cochrane.org.
Donald P McDonnell Side eff ects of progestagens, the menopause at the millennium / Donald P. McDonnell. – London- New York. – 2000. – 720 p.
Rutanen EM Biology of the endometrium, progress in the Management of the Menopause / Rutanen E.-M. – London- New York. – 1999. 490 p.
HA van Leusden The use of tranexamic acid and norethisterone at menorrhagia / Van Leusden HA // Mother and Child. – 2007. – Vol. 15. – № 3.
Rybo G Тreatment of menorrhagia using intrauterine administration of levonorgestrel / Rybo G. // Gynecology Forum. – Vol.3, No.3. – 1998. – Р. 20–22.
Thompson JR Analysis of menstrual bleeding dairy data. Hormone replacement therapy and the endometrium /Thompson J.R – Farook Al – Azzawi, USA. – 2001. – 172 p.
David Gordon J, Speroff L Dysfunctional Uterine Bleeding / David J., L.Gordon // Handbook for Clinical Gynecologic Endocrinology and Infertility, 2002, USA, 490 p.
Picolet H et al. Eff ects of dydrogesterone on hydroelectrolytic metabolism: a randomized double-blind study. Gynecol Endocrinol 1990; 4: 219–24.
Queisser-Luft A Dydrogesterone use during pregnancy: overview of birth defects reported since 1977. Early Hum Dev. – 2009. – P. 375–377.
Raghupathy R Progesteron-receptor mediated immunomodulation and antiabortive eff ects (II). The role of a protective Th-2 bias. Inter. Soc. Gynecol. Endocrin. Congress. Hong-Kong, 2001.
Rogerio A Lobo «Рrogestagens» Menopause: Biology and Pathobiology, 2000, р. 429–444.
Schindler AF Progestational eff ects of dydrogesterone in vitro, in vivo and on the human endometrium. Maturitas 65S. 2009: S3–11.
Schindler AF Progestational eff ects of dydrogesterone in vitro, in vivo and on the human endometrium. Maturitas 65S. 2009: S3–11.
Vovk IB Treatment of juvenile uterine bleeding at puberty / I.B. Vovk, VF Petersburgska, ZB Hominska / Pediatrics, Obstetrics and Gynecology. – 2002. – №2. – P. 125–128.
Glukhovets BI, Glukhovets NG Uterine bleeding: etiology, pathogenesis, morphological diagnosis // BI Glukhovets, NG. Gluhovets. – Saint-Petersburg: Grail. – 2000. 250 pp.
Order of the Ministry of Health of Ukraine № 582. Dysfunctional uterine bleeding in women of reproductive and perimenopausal age.
Manukhin IB Clinical lectures on endocrine gynecology / IB Manukhin, LG Tumilovich, MA Gevorgyan. M.: Med. News Agency. – 2001. – 247 p.
Pobedinskiy NM Steroid receptors of normal endometrium / NM Pobedinskiy, OI Baltutskaya, AI Omelyanenko / Obstetrics & Gynecology. – 2000. – № 3. – P. 5–8.
Podzolkova NM Diagnosis. Diff erential diagnosis in gynecology / NM Podzolkova, OL Glazkov. – M.: GEOTAR-Media, 2005. – 520 p.
Saidova RA Selected lectures on gynecology / RA Saidova, AD Makatsaria. – Moscow, 2005. – 256 p.
Saidova RA Pathogenesis of juvenile and uterine bleeding in patients with latent forms of hemostatic disorders / RA Saidova, AD Makatsaria / News of the Russian Association of Obstetricians and Gynecologists. – 2000. – № 3. – P. 34–37.
Tatarchuk TF Principles of progestogens use in gynecology / TF Tatarchuk // Doctor. – 2001. – № 3. – P. 39–42.
Tatarchuk TF Clinical and pathogenic variants, diagnosis and treatment of dysfunctional uterine bleeding in women of reproductive age / TF Tatarchuk, OB Bulavenko, OI Bodryagova / Drugs of Ukraine. – 2008. – № 4. – P. 102–109.
Tatarchuk TF Receptor characteristics and cytokine profi le of the endometrium at luteal phase defect / TF Tatarchuk, TD Zadorozhnaya, OV Bulavenko, TV Shevchuk // Reproductive women health. – 2007. – № 5 (34). – P. 142-146.
Tatarchuk TF Principles of diagnosis and treatment of dysfunctional uterine bleeding in the reproductive period / TF Tatarchuk, SI Regeda // Doctor. – 2004. – № 1. – P. 73–81.
Stepula VV, Lukyanchuk OV, Rybin AI Prevention of disorders of ovarian- menstrual cycle in women of reproductive age after fractional curettage of uterus / VV Stepula, OV Lukyanchuk, AI Rybin // Reproductive Health of Women. – 2008. – № 2 (36). – P. 120–122.