DOI: https://doi.org/10.18370/2309-4117.2013.11.51-60

Causes and prevention of repeated In Vitro fertilization failure

Л. О. Михайлишин

Abstract


The thesis presents the theoretical basis and a new solution of an actual problem of modern gynecology and reproductive medicine, namely increasing efficiency of ART through the development and practical implementation of diagnostic and therapeutic algorithms for patients with repeated IVF failures based on a comprehensive study of their genesis. Immunological prognostic markers of of repeated IVF failure factors have been identified. Indications for the use immune modulation therapy in preparing women with repeated IVF failure and proven effectiveness of the proposed immune adjustment therapy. The efficiency of diagnostic-medical algorithm of supervising patients with repeated IVF failure was developed and demonstrated.

Keywords


repeated IVF failure; implantation and embryological factors; reproductive immunology

References


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Beer AE Th-1 ⁄ Th-2 natural killer cell activation systemically and locally in the endometrium and therapeutic options / AE Beer // Am J ReprodImmunol. – 2001. – № 23. – Vol. 45. – Р. 137–139.

Carp HJA Autoantibodies as predictors of pregnancy complications / PL Meroni, Y Shoenfeld / HJA Carp // Elseiver. – 2007. – P. 809–814.

Сarp HJA Anti-phospholipid antibodies and infertility / HJA Carp // Clin. Rev. Allergy Immunol. – 2007. – № 32. – Р. 159–161.

Christiansen OB Future directions of failed implantation and recurrent miscarriage research / OB Christiansen, HS Nielsen, AM Kotle // Reprod Biomed Online. – 2006. – № 13. – P. 71–83.

Christiansen OB Intravenous immunoglobulin in the prevention of reccurent miscarriage: does it work? / OB Christiansen, HS Nielsen // Chem. Immunol Allergy. – 2005. – Vol. 88. – P. 117–127.

Clark DA Is intravenous immunoglobulin (IVIG) efficacious in early pregnancy failure? A critical review and meta-analysis for patients who fail in vitro fertilization and embryo transfer (IVF) / DA Clark, CB Coulam, RB Striker // J. Assist. Reprod. Genet. – 2006. – Vol. 23. – № 1. – Р. 1–13.

Cooper MA The biology of human natural killer-cell subsets / MA Cooper, TA Fehniger, MA Caligiuri // Trends Immunol. – 2001. – № 22. – Р. 633–640.

Сoulam CB Intravenous immunoglobulin for in vitro fertilization failure / CB Coulam, LW Kruse, M Bustillo // Hum. Reprod. – 1994. – Vol. 9. – № 12. – P. 2265–2269.

Cytokine-dependent abortion in CBA X DBA⁄ A2 mice is mediated by procoagulant fg12 prothrombinase / DA Clark, G Chaouat, РС Arck [et al.] // J Immunol. – 1998. – № 160. – Р. 545–549.

Daya S Intravenous immunoglobulin therapy for reccurent spontaneous abortion: a metaanalysis / S Daya, J Gunby, DA Clark // Am. J. Reprod. Immunol. – 1998. – Vol. 39. – № 2. – P. 69–76.

Detailed analysis of peripheral blood natural killer (NK) cells in women withwith

recurrent miscarriage / K King, S Smith, M Chapman [et al.] // Human Reproduction. – 2010. – № 25 (1). – Р. 52–58.

Effect of T-helper cytokines on secretion of T-helper 2 by term tropholast cells

in culture / R Agarwal, А Loganath, А Roy [et al] // Gynecol. Endocrynol. – 2000. –

V. 14. – P. 305–310.

Elram T Treatment of recurrent IVF failure and human leukocyte antigen similary by intravenous immunoglobulin / T Elarm, A Simon, S Israel // Reprod. Biomed. Online. – 2005. – Vol. 11. – P. 745–749.

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Leukemia inhibitory factor gene mutations in the population of infertile women are not restricted to nulligravid patients / M Kralickova, R Sima, Т Vanecek [et al.] // Eur J ObstetGynecolReprod Biol. – 2006. – № 127. – Р. 231–235.

Localization of the Th2 cytokines IL-3, IL-4, IL-10, at the fetomaternal interface during human and murine pregnancy and lack of requirement for Fas/fas ligand interaction for a successful allogenic pregnancy / G Chaouat, V Cayol, V Mairovitz [et al.] // Am. J.Reprod. Immunol. – 1999. – V. 42. – P. 1–13.

Meroni PL Updating on the Pathogenetic Mechanisms of the Antiphospholipid Antibodies-Associated Pregnancy Loss / PL Meroni, М Gerosa, Е Raschi // Clinic. Rev. Allerg. Immunol. – 2008. – № 34. – Р. 332–337.

Newland AC The use and mechanisms of action of intravenous immunoglobulin: an update / AC Newland // Br. J. Haematol. – 1989. – V. 72. – P. 301–305.

Nyboe Andersen A European IVF-monitorig (EIM) Consortium, for the European Society ofHuman Reproduction and Embryology (ESHRE). Assisted reproductive technology and intrauterine inseminations in Europe, 2005: results generated from European registers by ESHRE / A Nyboe Andersen // Hum. Reprod. – 2009. – Vol. 24. – P. 1267–1287.

Nydegger UE Hypothetic and established action mechanisms of therapy with immunoglobuline G / Nydegger UE // Immunotherapy and Intravenous Immunoglobulins, P. Imbach (ed.). – London: Acad. Press, 1991. – P. 27–36.

Obstetric uses of intravenous immunoglobulin: successes, failures, and promises / DW Branch, TF Porter, MJ Paidas [et al.] // J. Allergy Clin. Immunol. – 2001. – Vol. 108. – № 4. – P. S133–S138.

Porter TF Immunotherapy for recurrent miscarriage / TF Porter, Y LaCoursiere, JR Scott // Cochrane Database Syst. Rev. – 2006. – Issue 2. – Art. CD00112.

Raghupathy R Maternal type-1 reactivity is associated with several complications of pregnancy/ R Raghupathy, М Makhseed, F Azizieh. – Fertility and Sterility. – 2010. – Vol. 92. – Is. 4 – P. 231–232.

Raghupathy R Th1-type immunity is incompatible with successful pregnancy / R Raghupathy // Immunol Today. – 1997. – Vol. 18. – P. 478–482.

Robertson MJ Biology and clinical relevance of human natural killer cells / MJ Robertson, J Ritz // Blood. – 1990. – № 76. – Р. 2421–2438.

Role of interferon-gamma in the priming of decidual macrophages for nitric oxide production and early pregnancy loss / EK Haddad, AJ Duclos, E Antecka [et al.] // Cell Immunol. – 1997. – № 3. – Р. 75–68.

Serial estimation of Th1:Th2 cytokines profile in woman undergoing in vitro fertilization-embryo transfer / E Kalu, S Bhaskaran, MY Thum [et al.] // Am J reprodImmunol. – 2008. – № 59. – Р. 206–211.

Simple enumerations of peripheral blood natural killer (CD56+ NK) cells, B cells and T cells have no predictive value in IVF treatment outcome / MY Thum, S Bhaskaran, AS Bansal [et al.] // Human Reproduction. – 2005. – № 20 (5). – Р. 1272–1276.

Somigliana E Endometriosis and unexplained recurrentspontaneous abortion: pathological states resulting from aberrant modulation of natural killer cell function? / E Somigliana, P Vigano, M Vignali // Hum. Reprod. Update. – 1999. – V. 5, № 1. – P. 40–51.

T- helper 1 and 2 immune responses in relationship to pregnancy, nonpregnancy, reccurent spontaneous abortions and infertility of repeated implantation failures / JY Kwak-Kim, A Gilman-Sachs, CE Kim [et al.] // Chem Immunol. Allergy. – 2005. – № 88. – Р. 64–79.

Th2/Th3 cytokines genotypes are associated with pregnancy loss / PA Costeas, A Koumouli, F Giantsiou-Kyriakou [et al.] // Hum. Immunol. – 2004. – № 65. – P. 135–141.

Treatment with adalimubab (Humira) and intravenous immunoglobulin improves pregnancy rates in woman undergoing IVF / EE Winger, JL Reed, S Ashoush [et al.] // Am J ReprodImmunol. – 2009. – № 61. – Р. 113–120.

Use of intravenous immunoglobulin for treatment of recurrent miscarriage: a systematic review / B Hutton, R Sharma, D Fergusson [et al.] // Br. J. Obstet. Gynaecol. – 2007. – Vol. 114. – № 2. – P. 134–142.

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A randomized, double-blind, placebo-controlled trial of intravenous immunoglobulin in the prevention of reccurent miscarriage: evidence for the therapeutic effect in women with secondary reccurent miscarriage / OB Christiansen, B Pedersen, A Rosgaard [et al.] // Hum. Reprod. – 2002. – Vol. 17. – № 3. – P. 809–901.

Assisted reproductive technology in Europe, 2001. Results generated from European registers by ESHRE / AN Andersen, L Gianaroli, R Felberbaum [et al.] // Human Reprod. – 2005. – V. 20. – P. 1158–1176.

Beer AE Th-1 ⁄ Th-2 natural killer cell activation systemically and locally in the endometrium and therapeutic options / AE Beer // Am J ReprodImmunol. – 2001. – № 23. – Vol. 45. – Р. 137–139.

Carp HJA Autoantibodies as predictors of pregnancy complications / PL Meroni, Y Shoenfeld / HJA Carp // Elseiver. – 2007. – P. 809–814.

Сarp HJA Anti-phospholipid antibodies and infertility / HJA Carp // Clin. Rev. Allergy Immunol. – 2007. – № 32. – Р. 159–161.

Christiansen OB Future directions of failed implantation and recurrent miscarriage research / OB Christiansen, HS Nielsen, AM Kotle // Reprod Biomed Online. – 2006. – № 13. – P. 71–83.

Christiansen OB Intravenous immunoglobulin in the prevention of reccurent miscarriage: does it work? / OB Christiansen, HS Nielsen // Chem. Immunol Allergy. – 2005. – Vol. 88. – P.  117–127.

Clark DA Is intravenous immunoglobulin (IVIG) efficacious in early pregnancy failure? A critical review and meta-analysis for patients who fail in vitro fertilization and embryo transfer (IVF) / DA Clark, CB Coulam, RB Striker // J. Assist. Reprod. Genet. – 2006. – Vol. 23. – № 1. – Р. 1–13.

Cooper MA The biology of human natural killer-cell subsets / MA Cooper, TA Fehniger, MA Caligiuri // Trends Immunol. – 2001. – № 22. – Р. 633–640.

Сoulam CB Intravenous immunoglobulin for in vitro fertilization failure / CB Coulam, LW Kruse, M Bustillo // Hum. Reprod. – 1994. – Vol. 9. – № 12. – P. 2265–2269.

Cytokine-dependent abortion in CBA X DBA⁄ A2 mice is mediated by procoagulant fg12 prothrombinase / DA Clark, G Chaouat, РС Arck [et al.] // J Immunol. – 1998. – № 160. – Р. 545–549.

Daya S Intravenous immunoglobulin therapy for reccurent spontaneous abortion: a metaanalysis / S Daya, J Gunby, DA Clark // Am. J. Reprod. Immunol. – 1998. – Vol. 39. – № 2. – P. 69–76.

Detailed analysis of peripheral blood natural killer (NK) cells in women withwith

recurrent miscarriage / K King, S Smith, M Chapman [et al.] // Human Reproduction. – 2010. – № 25 (1). – Р. 52–58.

Effect of T-helper cytokines on secretion of T-helper 2 by term tropholast cells

in culture / R Agarwal, А Loganath, А Roy [et al] // Gynecol. Endocrynol. – 2000. –

V. 14. – P. 305–310.

Elram T Treatment of recurrent IVF failure and human leukocyte antigen similary by intravenous immunoglobulin / T Elarm, A Simon, S Israel // Reprod. Biomed. Online. – 2005. – Vol. 11. – P. 745–749.

Gueri LR Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? / LR Gueri, JR Prins, SA Robertson // Human Reprod Update. – 2009. – Vol. 1. – Is. 1. – P. 1–19.

Hill JA Maternal immunological aspects of pregnancy success and failure / JA Hill, BC Choi // J. ReprodFertil Suppl. – 2000. – № 55. – P. 91–97.

Hill JA Cytocines considered critical in pregnancy / JA Hill // Am. J. Reprod. Immunol. – 1992. – Vol. 28 (3–4). – P. 123–126.

Infectious Tolerance: human CD25+regulatory T cells convey suppressor activity to conventional CD4+T hepler cells / H Jonuleit, Е Schmitt, Н Kakirman [et al.] // J Exp Med. – 2002. – Vol. 196. – P. 255–260.

Kitaya K Accumulation of uterine CD16- natural killer (NK) cells: friens, foes, or Jekyll-and-Hyde relationship for the conceptus? / K Kitaya // Immunol Inv. – 2008. – Vol. 37. – Is. 5. – P. 467–481.

Lanier LL On guard–activating NK cell receptors / LL Lanier // Nat Immunol. – 2001. – № 2. – Р. 23–27.

Leukemia inhibitory factor gene mutations in the population of infertile women are not restricted to nulligravid patients / M Kralickova, R Sima, Т Vanecek [et al.] // Eur J ObstetGynecolReprod Biol. – 2006. – № 127. – Р. 231–235.

Localization of the Th2 cytokines IL-3, IL-4, IL-10, at the fetomaternal interface during human and murine pregnancy and lack of requirement for Fas/fas ligand interaction for a successful allogenic pregnancy / G Chaouat, V Cayol, V Mairovitz [et al.] // Am. J.Reprod. Immunol. – 1999. – V. 42. – P. 1–13.

Meroni PL Updating on the Pathogenetic Mechanisms of the Antiphospholipid Antibodies-Associated Pregnancy Loss / PL Meroni, М Gerosa, Е Raschi // Clinic. Rev. Allerg. Immunol. – 2008. – № 34. – Р. 332–337.

Newland AC The use and mechanisms of action of intravenous immunoglobulin: an update / AC Newland // Br. J. Haematol. – 1989. – V. 72. – P. 301–305.

Nyboe Andersen A European IVF-monitorig (EIM) Consortium, for the European Society ofHuman Reproduction and Embryology (ESHRE). Assisted reproductive technology and intrauterine inseminations in Europe, 2005: results generated from European registers by ESHRE / A Nyboe Andersen // Hum. Reprod. – 2009. – Vol. 24. – P. 1267–1287.

Nydegger UE Hypothetic and established action mechanisms of therapy with immunoglobuline G / Nydegger UE // Immunotherapy and Intravenous Immunoglobulins, P. Imbach (ed.). – London: Acad. Press, 1991. – P. 27–36.

Obstetric uses of intravenous immunoglobulin: successes, failures, and promises / DW Branch, TF Porter, MJ Paidas [et al.] // J. Allergy Clin. Immunol. – 2001. – Vol. 108. – № 4. – P. S133–S138.

Porter TF Immunotherapy for recurrent miscarriage / TF Porter, Y LaCoursiere, JR Scott // Cochrane Database Syst. Rev. – 2006. – Issue 2. – Art. CD00112.

Raghupathy R Maternal type-1 reactivity is associated with several complications of pregnancy/ R Raghupathy, М Makhseed, F Azizieh. – Fertility and Sterility. – 2010. – Vol. 92. – Is. 4 – P. 231–232.

Raghupathy R Th1-type immunity is incompatible with successful pregnancy / R Raghupathy // Immunol Today. – 1997. – Vol. 18. – P. 478–482.

Robertson MJ Biology and clinical relevance of human natural killer cells / MJ Robertson, J Ritz // Blood. – 1990. – № 76. – Р. 2421–2438.

Role of interferon-gamma in the priming of decidual macrophages for nitric oxide production and early pregnancy loss / EK Haddad, AJ Duclos, E Antecka [et al.] // Cell Immunol. – 1997. – № 3. – Р. 75–68.

Serial estimation of Th1:Th2 cytokines profile in woman undergoing in vitro fertilization-embryo transfer / E Kalu, S Bhaskaran, MY Thum [et al.] // Am J reprodImmunol. – 2008. – № 59. – Р. 206–211.

Simple enumerations of peripheral blood natural killer (CD56+ NK) cells, B cells and T cells have no predictive value in IVF treatment outcome / MY Thum, S Bhaskaran, AS Bansal [et al.] // Human Reproduction. – 2005. – № 20 (5). – Р. 1272–1276.

Somigliana E Endometriosis and unexplained recurrentspontaneous abortion: pathological states resulting from aberrant modulation of natural killer cell function? / E Somigliana, P Vigano, M Vignali // Hum. Reprod. Update. – 1999. – V. 5, № 1. – P. 40–51.

T- helper 1 and 2 immune responses in relationship to pregnancy, nonpregnancy, reccurent spontaneous abortions and infertility of repeated implantation failures / JY Kwak-Kim, A Gilman-Sachs, CE Kim [et al.] // Chem Immunol. Allergy. – 2005. – № 88. – Р. 64–79.

Th2/Th3 cytokines genotypes are associated with pregnancy loss / PA Costeas, A Koumouli, F Giantsiou-Kyriakou [et al.] // Hum. Immunol. – 2004. – № 65. – P. 135–141.

Treatment with adalimubab (Humira) and intravenous immunoglobulin improves pregnancy rates in woman undergoing IVF / EE Winger, JL Reed, S Ashoush [et al.] // Am J ReprodImmunol. – 2009. – № 61. – Р. 113–120.

Use of intravenous immunoglobulin for treatment of recurrent miscarriage: a systematic review / B Hutton, R Sharma, D Fergusson [et al.] // Br. J. Obstet. Gynaecol. – 2007. – Vol. 114. – № 2. – P. 134–142.





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