DOI: https://doi.org/10.18370/2309-4117.2012.3.64-67

Клиническая оценка эффективности и переносимости проместрина у женщин в менопаузе с атрофическим вагинитом

Salim Cesar E. Fernandes Wehba

Abstract


Слизистая оболочка, покрывающая влагалище, очень чувствительна к уровню эстрогенов, который изменяется в менопаузе. Влагалищный эпителий теряет свою складчатость, становится тонким, бледным, иногда видны небольшие петехии. Увеличивается объем соединительной ткани, утрачивается эластичность тканей влагалища. Оно суживается и укорачивается, что зачастую приводит к диспареунии и сексуальным проблемам, связанным с ригидностью и контрактурой вульвовагинального отверстия.

References


Semmens J.P., Wagner C. Estrogen deprivation and vaginal function in post- menopausal women. // Jama. – 1982. – Vol. 248. – P. 445.

losif C., Bekassy Z. Prevalence of genito-urinary symptoms in the late menopause // Аcta Obstet. Gynecol. Scand. – 1984. – Vol. 63. – P. 257-260.

Berg С. et al. Climateric symptoms among women aged 60–62 in Linkoping, Sweden, in 1906 // Maturitas. – 1988. – Vol. 10. – P. 193–199.

Wurch T.H.A. et al. Interet du promestriкne dans le trailement de la vaginite atrophique postmenopausique. // Gynecologie. – 1981. – Vol. 32. – P. 551.

Schi I. et al. Vaginal absorption of estrone and 17 beta estradiol // Fertil. Steril. – 1978. – Vol. 28. – P. 1063.

Rigg L.A. et al. Absorption of estrogens from vaginal creams // N. Engl. J. Med. – 1978. – Vol. 298. – P. 195.

Wolf J.P. et al. Absence of systemic hormonal effects in an estradiol diether topically active on the vaginal mucosa // Maturitas. – 1962. – Vol. 4. – P. 239.

Wehba S. et al. Uso do pro-mestriene por via vaginal. Avaliacado da colpocitologia hormonal, dos nieis plasmaticos de gonadotfofinas estradiol em mulheres nа menopausa. Analise da eficacia e tolerabilidade // J. Bras. Ginecol. – 1991. – Vol. 101. – P. 1.

Semmens J.P., Wagner G. Estrogen deprivation and vaginal function in post- menopausal women // Jama. – 1982. – Vol. 48. – P. 445.

Villani L. et al. Troubles trophiques en gynecologie du trosieme age // Medecine et 3-e Age. – 1978. – Vol. 1. – P. 315.

Guіchard M. Interel du promestrine dans les dyspareunies et anorgasmies feminines // Sexologie. – 1978. – Vol. 7.

Turdjman G. Y-a-1-il un traitement local des dyspareunies et de la secheresse vaginale? // Cah. Sexol. Clin. – 1978. – Vol. 4. – P. 22.

Palacios S.J. et al. Local and systemic effects after the intravaginal administration of estrogens (promestrien) in menopausal women: World Congress of Gynecology and Obstetrics. – Berlin (West) // Arch. Gynecol. – 1985. – Vol. 237. – P. 152.

Deutsch S.I. Ossowski R., Benjamin I. Comparison between degree of systemic absorption of vaginally and orally administered estrogens at different dose levels in postmenopausal women // Am. J. Obstet. Gynecol. – 1981. – Vol. 139. – P. 967.

Mandel F.P. et al. Biological effects of various doses of vaginally administered conjugated equine estrogens at different dose levels in postmenopausal women // J. Clin. Endocrinol. Metab. – 1983. – Vol. 57. – Vol. 133.

Brown K.H., Hamond C.B. Urogenital atrophy // Em.: Grambrell R.O. Obstetrics and gynecology clinics of North America. The menopause. – Philadelphia: W.B. Saunders, 1987. – P. 13.


GOST Style Citations


Semmens J.P., Wagner C. Estrogen deprivation and vaginal function in post- menopausal women. // Jama. – 1982. – Vol. 248. – P. 445.

losif C., Bekassy Z. Prevalence of genito-urinary symptoms in the late menopause // Аcta Obstet. Gynecol. Scand. – 1984. – Vol. 63. – P. 257-260.

Berg С. et al. Climateric symptoms among women aged 60–62 in Linkoping, Sweden, in 1906 // Maturitas. – 1988. – Vol. 10. – P. 193–199.

Wurch T.H.A. et al. Interet du promestriкne dans le trailement de la vaginite atrophique postmenopausique. // Gynecologie. – 1981. – Vol. 32. – P. 551.

Schi I. et al. Vaginal absorption of estrone and 17 beta estradiol // Fertil. Steril. – 1978. – Vol. 28. – P. 1063.

Rigg L.A. et al. Absorption of estrogens from vaginal creams // N. Engl. J. Med. – 1978. – Vol. 298. – P. 195.

Wolf J.P. et al. Absence of systemic hormonal effects in an estradiol diether topically active on the vaginal mucosa // Maturitas. – 1962. – Vol. 4. – P. 239.

Wehba S. et al. Uso do pro-mestriene por via vaginal. Avaliacado da colpocitologia hormonal, dos nieis plasmaticos de gonadotfofinas estradiol em mulheres nа menopausa. Analise da eficacia e tolerabilidade // J. Bras. Ginecol. – 1991. – Vol. 101. – P. 1.

Semmens J.P., Wagner G. Estrogen deprivation and vaginal function in post- menopausal women // Jama. – 1982. – Vol. 48. – P. 445.

Villani L. et al. Troubles trophiques en gynecologie du trosieme age // Medecine et 3-e Age. – 1978. – Vol. 1. – P. 315.

Guіchard M. Interel du promestrine dans les dyspareunies et anorgasmies feminines // Sexologie. – 1978. – Vol. 7.

Turdjman G. Y-a-1-il un traitement local des dyspareunies et de la secheresse vaginale? // Cah. Sexol. Clin. – 1978. – Vol. 4. – P. 22.

Palacios S.J. et al. Local and systemic effects after the intravaginal administration of estrogens (promestrien) in menopausal women: World Congress of Gynecology and Obstetrics. – Berlin (West) // Arch. Gynecol. – 1985. – Vol. 237. – P. 152.

Deutsch S.I. Ossowski R., Benjamin I. Comparison between degree of systemic absorption of vaginally and orally administered estrogens at different dose levels in postmenopausal women // Am. J. Obstet. Gynecol. – 1981. – Vol. 139. – P. 967.

Mandel F.P. et al. Biological effects of various doses of vaginally administered conjugated equine estrogens at different dose levels in postmenopausal women // J. Clin. Endocrinol. Metab. – 1983. – Vol. 57. – Vol. 133.

Brown K.H., Hamond C.B. Urogenital atrophy // Em.: Grambrell R.O. Obstetrics and gynecology clinics of North America. The menopause. – Philadelphia: W.B. Saunders, 1987. – P. 13.





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