The role of connective tissue metabolism disorders in the genesis of stress urinary incontinence in premenopausal women

Authors

DOI:

https://doi.org/10.18370/2309-4117.2023.68.89-93

Keywords:

stress urinary incontinence, connective tissue, synthesis marker, resorption marker, trace elements, vitamins

Abstract

Research objectives: to study the pathogenetic links in the development of stress urinary incontinence (SUI) by determining the state of connective tissue (CT), concentrations of trace elements, vitamins and estradiol in premenopausal women.
Materials and methods. 189 women aged 45–55 years with SUI were examined. In addition to general clinical examination, concentrations of Total PІNP (type I collagen synthesis marker) and Total PІІІNP (type III collagen synthesis marker) and CT resorption marker Pyriliks-D, ionized magnesium, ionized calcium, total calcium, vitamins D and C, estradiol were studied in the blood serum in order to determine the state of fibrous CT.
Results. In the structure of somatic morbidity were conditions defined as phenotypic manifestations of CT undifferentiated dysplasia. A decrease of the Total PІNP by 24.9% was found against the background of an increased Total PІІІNP by 46.7% and an increased Pyriliks-D by 54.1%. Women with SUI were characterized by a significant decrease in the average value of Mg2+ by an average of 16.7%, as well as a significant increase in the average value of Ca2+ by 5.3% and total Ca by 3.9%. The vitamin balance study shows a significant decrease of vitamin D by 40.6% and vitamin C by 37.0%. Estradiol concentration was at the minimum values of the physiological norm.
Conclusions. Women in premenopausal age with SUI are characterized by a violation of the CT synthesis and resorption, which are realized by reducing the formation of the Total PІNP against the background of intensification of the Total PІІІNP and Pyriliks-D synthesis, combined with a disbalance of vitamins and trace elements. These features are highly likely to be considered as predictors of the SUI development in women of premenopausal age

Author Biographies

V.O. Beniuk, O.O. Bogomolets National Medical University, Kyiv

MD, Professor

 

Professional interests: miscarriage, endometrial hyperplastic processes, modern diagnostic and operative techniques in gynecology

 

Scopus Profile: link

ID ORCID: 0000-0002-5984-3307

ResearcherID: link

Google Scholar: link

 

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M.S. Puchko, O.O. Bogomolets National Medical University, Kyiv

Assistant, Obstetrics and Gynecology Department No. 3

Y.H. Drupp, O.O. Bogomolets National Medical University, Kyiv

PhD, associate professor, Obstetrics and Gynecology Department No. 3

T.R. Nykoniuk, O.O. Bogomolets National Medical University, Kyiv

PhD, associate professor, Obstetrics and Gynecology Department No. 3

V.F. Oleshko, O.O. Bogomolets National Medical University, Kyiv

PhD, assistant, Obstetrics and Gynecology Department No. 3,

A.A. Momot, O.O. Bogomolets National Medical University, Kyiv

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Published

2023-06-30

How to Cite

Beniuk, V., Puchko, M., Drupp, Y., Nykoniuk, T., Oleshko, V., Momot, A., & Kovaliuk, T. (2023). The role of connective tissue metabolism disorders in the genesis of stress urinary incontinence in premenopausal women. REPRODUCTIVE ENDOCRINOLOGY, (68), 89–93. https://doi.org/10.18370/2309-4117.2023.68.89-93

Issue

No. 68 (2023)

Section

Management of menopause

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Copyright (c) 2023 В.О. Бенюк, М.С. Пучко, Ю.Г. Друпп, Т.Р. Никонюк, В.Ф. Олешко, А.А. Момот, Т.В. Ковалюк

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