Placental disorders in displaced pregnant women who are in persistent stress




pregnancy, complications, prophylaxis, placenta, stress, displaced persons


Objectives: to determine morphological and immunohistochemical changes in the placentas of displaced pregnant women in order to further improve the antenatal monitoring program.
Materials and methods. 96 displaced pregnant women (the main group) took part in the prospective study, who depending on the therapy were divided into: group I – 65 pregnant women who were monitored according to generally accepted recommendations and received routine therapy for prolonging pregnancy, group II – 31 pregnant women who received the proposed treatment and prophylactic complex (micronized progesterone, magnesium citrate in combination with pyridoxine hydrochloride, iron fumarate, a multivitamin complex with 200 mg of docosahexaenoic acid, complex of medical and psychological support for pregnant women). The control group consisted of 39 pregnant women living at territories controlled by Ukraine. The duration of observation was 2 years. Placentas were examined by organometric, macroscopic, general histological and immunohistochemical methods.
Results. Organometrically, placentas in the group I had a significant decrease in thickness, mass and size. Edema of Wharton jelly was significantly more pronounced in this group, and in the lumen of vessels there was a more pronounced parietal formation of fibrin blood clots. Manifestations of ischemic infarcts and blood clots, which were located mainly in the paracentral and peripheral zones, were found significantly more frequently among women of the group I. Histologically, tissue changes were noted in the placentas in the group I, which are manifestations of placental damage and characterized by a partial decrease in maternal-fetal-placental perfusion. These changes were combined with focal edema in decidual tissue and dystrophy in decidual cells. In the placentas of women of the group I an uneven focal, sometimes pronounced proliferation of syncytial nodules of a more widespread nature was noted, which is a marker of cellular aging associated with adverse factors affecting the mother’s body. Also, foci of maternal infarcts were noted in the group I, which is associated with a decrease in maternal perfusion in the vessels of the placental barrier.
Immunohistochemically, vacuolization and uneven chromatin arrangement were observed in the nuclei of villi cells during Ki-67 immersion, which indicated a decrease in regenerative responses in the placental barrier in groups I and II, especially with elevated cortisol levels. Immunohistochemical studies of the pro-apoptotic marker P-53 showed expression in single nuclei of villi stroma cells.
Conclusions. The detected changes in the structures of the placental barrier indicate the predominance of placental disorders in the group I compared to the group II and control groups, especially in the syncytium of the villi, which led to a violation of the placenta functioning. Morphological studies confirmed the significant impact of long-term chronic stress on the formation and functioning of the uterine-placental-fetal complex, as well as the effectiveness of the proposed treatment in preventing the identified disorders.

Author Biographies

I.A. Zhabchenko, SI “O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”, Kyiv

MD, professor, сhief of the Department of pathology of pregnancy and childbirth

T.D. Zadorozhna, SI “O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”, Kyiv

MD, professor, correspondent member of the NAMS of Ukraine, head of the Pathomorphological Laboratory

S.V. Tertychna-Teliuk, SI “Luhansk State Medical University”, Rivne

PhD, assistant, Department of Obstetrics and Gynecology

V.K. Likhachov, Poltava State Medical University, Poltava

MD, professor, head of the Department of Obstetrics and Gynecology No. 2

N.H. Korniiets, SI “Luhansk State Medical University”, Rivne

PhD, associate professor, head of the Department of Obstetrics and Gynecology

V.F. Oleshko, O.O. Bogomolets National Medical University, Kyiv

PhD, assistant, Department of Obstetrics and Gynecology No. 3

Y.M. Slіepichko, Central City Hospital of Rubizhne, Dnipro

PhD, obstetrician-gynecologist


  1. Antypkyn, Y.G. Academic lectures on obstetrics and gynecology. Ed. by acad. Y.G. Antypkin. Kyiv. Creative Media (2021): 424 р.
  2. Antypkin, Y.G., Zadorozhna, T.D., Parnytska, O.I. Pathology of the placenta (modern aspects). Kyiv. Atopol (2016): 128 р.
  3. Ancheva, I.A. “Psychoprophylaxis of stress during pregnancy and childbirth.” Women’s Health 5.121 (2017): 32–4.
  4. Baraboy, V.A., Reznikov, O.G. Physiology, biochemistry and psychology of stress. Kyiv. Interservis (2013): 314 р.
  5. Vdovichenko, Y.P., Zhuk, S.I., Shchurevska, O.D. Support for pregnancy and childbirth in conditions of social stress. Methodological recommendations. Kyiv. Print Line (2014): 64 p.
  6. Vdovichenko, Y.P., Tanko, O.P., Samoylova, M.V., Sharashidze, K.Z. Fetal Growth Retardation: Clinical and Pathogenetic Components and Means Warning. Kyiv (2017): 43 p.
  7. Dubossarska, Y.A., Dubossarska, Z.M., Zakharchenko, L.G., Borovkova, L.G. “Problems of reproductive health from the perspective of perinatal psychology.” Collection of Scientific Works of the Association of Obstetricians and Gynecologists of Ukraine 1/2 (33/34) (2014): 129–33.
  8. Zhuk, S.I., Shhurevska, O.D. “Features of the course of pregnancy and childbirth in internally displaced women.” Women’s Health 2 (2016): 16–8.
  9. Zhuk, S.I., Shсhurevska, O.D., Viter, V.P. “Prenatal stress and its consequences (literature review).” Women’s Health 1.97 (2015): 41–4.
  10. Zhuk, S.I., Shсhurevska, O.D. “Fetal stress programming.” Women’s Health 1.117 (2017): 116–19.
  11. Sіusіuka, V.G. Clinical and pathogenetic aspects of obstetric and perinatal complications in women, taking into account psychoemotional conditions and their medical and psychological correction: Thesis for the doctor’s degree of medical sciences. Zaporizhzhia (2018): 395 р.
  12. Sіusіuka, V.G. “Obstetric and perinatal consequences of psychoemotional disorders during pregnancy.” Young Scientist 2 (2015): 683–6.
  13. Khudaverdyan, A.D. Prognostic value of a comprehensive assessment of the features of blood circulation and hormonal balance in the mother-placenta-fetus system in pregnant women undergoing chronic psychoemotional stress: Thesis for the doctor’s degree of medical sciences. Yerevan (2016): 206 р.
  14. Khudaverdyan, A.D. “The content of cortisol in the blood of women during various periods of pregnancy and the effects of chronic stress.” Medical Science of Armenia NAS RA 2 (2015): 123–7.
  15. Khudaverdyan, A.D., Aznaurуan, A.V. “Histological characteristics of the placenta of women who have suffered acute and chronic psychoemotional stress.” New Armenian Medical Journal 10 (2016): 11–23.
  16. Amugongo, S.K., Hlusko, L.J. “Impact of maternal prenatal stress on growth of the offspring.” Aging Dis 5.1 (2014): 1–16.
  17. Brekhman, G.I., Fedor-Freybergh, P. Phenomenon of violence (From domestic to global). View from a position of prenatal and perinatal psychology and medicine. First publication: Haifa, News Agalil (2005): 240 p. (in English and Russian languages). Reprinted – Israel (2017). ISBN 9-78965-908-14-17.
  18. Ding, X.X., et al. “Maternal anxiety during pregnancy and adverse birth outcomes: a systematic review and meta-analysis of prospective cohort studies.” J Affect Disord 159 (2014): 103–10.
  19. Entringer, S., Buss, C., Wadhwa, P.D. “Prenatal stress, development health and disease risk: a psychological perspective-2015 Curt Richter Award Paper.” Psychoneuroendocrinology 62 (2015): 366–75.
  20. Glover, V. “Prenatal anxiety and depression, fetal programming and placental function.” Psychoneuroendocrinology 61 (2015): 3–4.
  21. Helbig, A., Kaasen, A., Malt, U.F., Haugen, G. “Does antenatal maternal psychological distress affect placental circulation in the third trimester?” PloS One 8 (2013): 1–7.
  22. Lewis, A.J., Austin, E., Knapp, R., et al. “Perinatal Maternal Mental Health, Fetal Programming and Child Development.” Healthcare (Basel) 3.4 (2015): 1212–27.
  23. Raymond, W. “Redline Classification of placental lesions.” Am J Obst Gynecol (2015): 21–8.
  24. Saeed, A., Raana, T., Saeed, A.M., Humayun, A. “Effect of antenatal depression on maternal dietary intake and neonatal outcome: a prospective cohort.” Nutr J 15.1 (2016): 64. DOI: 10.1186/s12937-016-0184-7
  25. Syusyuka, V.G. “Influence of anxiety on well-being, activity and mood of pregnant women during pregnancy”. Science without borders 2017: Materials of the XIII International scientific and practical conference (30 March – 07 April, 2017) on Agriculture. Medicine. Ecology. Veterinary. Biological sciences (2017): 3–5.



How to Cite

Zhabchenko, I., Zadorozhna, T., Tertychna-Teliuk, S., Likhachov, V., Korniiets, N., Oleshko, V., & Slіepichko Y. (2023). Placental disorders in displaced pregnant women who are in persistent stress . REPRODUCTIVE ENDOCRINOLOGY, (67), 107–113.



Pregnancy and childbirth