Efficiency of treatment and diagnostic algorithms in the rehabilitation program of women after hysterectomy with opportunist salpingectomy due to uterine myoma

Authors

DOI:

https://doi.org/10.18370/2309-4117.2022.66.90-97

Keywords:

hysterectomy with opportunistic salpingectomy, genitourinary syndrome, rehabilitation program

Abstract

Objectives: to determine the effectiveness of the rehabilitation program in women of reproductive age with uterine fibroids for correction of genitourinary syndrome after hysterectomy with opportunistic salpingectomy.
Materials and methods. 160 women were examined after hysterectomy with fallopian tubes. State of the urogenital tract and urogenital dysfunction researched with the using the POP-Q system,
the Barlow scale, vaginoscopy. Also it was used evaluation of the vaginal pH and mucosal microbiota state, assessment of the vaginal health index according to G. Bochmann, assessment of the impact of vulvovaginal symptoms on the life’s quality with the MOS SF-36 questionnaire in the dynamics of the postoperative period. The treatment algorithm included local preparations of hyaluronic acid, lactobacillus preparations in combination with vitamin D solution, in case of a severe course – topical estrogens, in case of vasomotor symptoms – estradiol 50 μg/day and vitamin D 4000 IU daily or 20,000 IU once a week.
Results. Manifestations of genitourinary syndrome were revealed 1 year after surgery, namely: hypotrophy of the vaginal mucous membrane in 36.3% of women, urinary incontinence in almost a third of patients, prolapse of the vaginal walls of the I–II degree in 8.8% of women, a pathological microscopic picture in 68.1% of female. The proposed algorithms in the rehabilitation program made it possible to eliminate or reduce the severity of genitourinary symptoms 5 years after hysterectomy, in particular, to reduce the frequency of vulvovaginal atrophy by 25%, to normalize the biocenosis and pH of the vaginal contents, to reduce the clinical manifestations of urination disorders (pollakiuria and nocturia by 14% and 12,8%, respectively), feeling of incomplete emptying of the bladder by 12.9%, stress urinary incontinence by 17.9%, vaginal prolapse by 13.3% compared to the group with standard postoperative management.
Conclusions. Hysterectomy with opportunistic salpingectomy for uterine fibroids has a positive effect on the life’s quality of patients by improving the physical comfort due to the reduction of clinical symptoms of uterine fibroids. However, changes in the quality of life after surgical intervention associated with disturbances in the psycho-emotional sphere were recorded in 49.4% of women, including those provoked by the manifestation of genitourinary syndrome in 19.3%. The proposed algorithm in the rehabilitation program made it possible to reduces the severity of genitourinary symptoms.

Author Biographies

O.M. Proshchenko, O.О. Bogomolets National Medical University, Kyiv

PhD, assistant professor, Department of Obstetrics and Gynecology No. 1

I.B. Ventskivska, O.O. Bogomolets National Medical University, Kyiv

MD, head of the Department of Obstetrics and Gynecology No. 1

References

  1. Fernandez, H., Farrugia, M., Jones, S.E., et al. “Rate, type, and cost of invasive interventions for uterine myomas in Germany, France, and England.” Minim Invasive Gynecol 16.1 (2009): 40–6.
  2. Gladchuk, I.Z., Rozhkovska, N.M., Kosey, T.V. “Modern surgical treatment technologies of uterine fibroids (literature review and own data).” Collection digest of Association of Obstetricians and Gynecologists of Ukraine 2.38 (2016):123–9.
  3. Whiteman, M.K., Hillis, S.D., Jamieson, D.J., et al. “Inpatient hysterectomy surveillance in the United States, 2000–2004.” Am J Obstet Gynecol 198.1 (2008): 34.e1–7.
  4. Edler, K.M., Tamussino, K., Fülöp, G., et al. “Rates and Routes of Hysterectomy for Benign Indications in Austria 2002–2014.” Geburtshilfe Frauenheilkd 77.5 (2017): 482–6. DOI: 10.1055/s-0043-107784
  5. Centers for Disease Control and Prevention. Key Statistics from the National Survey of Family Growth, Atlanta, GA: Centers for Disease Control and Prevention (2015). Available from: [http://www.cdc.gov/nchs/nsfg/ key_statistics/h.htm#hysterectomy].
  6. Harnod, T., Tsai, I.-J., Chen, W., et al. “Hysterectomy and unilateral salpingectomy associate with a higher risk of subsequent ovarian cancer.” Medicine 98.48 (2019). DOI: 10.1097/md.0000000000018058
  7. Morelli, M., Venturella, R., Mocciaro, R., et al. “Prophylactic salpingectomy in premenopausal low-risk women for ovarian cancer: Primum non nocere.” Gynecologic Oncology 129 (2013): 448–51.
  8. van Lieshout, L.A., Steenbeek, M.P., De Hullu, J.A., et al. “Hysterectomy with opportunistic salpingectomy versus hysterectomy alone.” Cochrane Database of Systematic Reviews 8.8 (2019): CD012858. DOI: 10.1002/14651858.cd012858.pub2
  9. Robinson, D., Ioozs-Hobson, P., Cardoso, L. “The effect of hormones on the lower urinary tract.” Menopause 19 (2013): 155–62.
  10. Moorman, P.G., Myers, E.R., Schildkraut, J.M., et al. “Effect of hysterectomy with ovarian preservation on ovarian function.” Obstet Gynecol 118.6 (2011): 1271–9. DOI: 10.1097/AOG.0b013e318236fd12
  11. Lüthje, P., Hirschberg, A.L., Brauner, A. “Estrogenic action on innate defense mechanisms in the urinary tract.” Maturitas 77 (2014): 32–6.
  12. Lukacz, E.S., Santiago-Lastra, Y., Albo, M.E., Brubaker, L. “Urinary incontinence in women. A review.” JAMA 318 (2017): 1592–604.
  13. Kim, H.K., Kang, S.Y., Chung, Y.J., et al. “The Recent Review of the Genitourinary Syndrome of Menopause.” J Menopausal Med 21.2 (2015): 65–71. DOI: 10.6118/jmm.2015.21.2.65
  14. Brotman, R.M., Shardell, M.D., Gajer, P., et al. “Association between the vaginal microbiota, menopause status, and sings of vulvovaginal atrophy.” Menopause 21.5 (2014): 450–8.
  15. Vomvolaki, E., Kalmantis, K., Kioses, E., et al. “The effect of hysterectomy on sexuality and psychological changes.” Eur J Contracept Reprod Health Care 11.1 (2006): 23–7. DOI: 10.1080/13625180500430200
  16. Matyjaszek-Matuszek, B., Lenart-Lipińska, M., Wozniakowska, E. “Clinical implications of vitamin D deficiency.” Prz Menopauzalny 14.2 (2015): 75–81. 10.5114/pm.2015.52149
  17. Abdul-Razzak, K.K., Alshogran, O.Y., Altawalbeh, S.M., et al. “Overactive bladder and associated psychological symptoms: A possible link to vitamin D and calcium.” Neurourology and Urodynamics 38 (2019): 1160–7. DOI: 10.1002/nau.23975
  18. Eyles, D.W., Smith, S., Kinobe, R., et al. “Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain.” J Chem Neuroanat 29.1 (2005): 21–30. DOI: 10.1016/j.jchemneu.2004.08.006
  19. Berridge, M.J. “Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis.” J Physiol 595 (2017): 6825–36. DOI: 10.1113/JP274887
  20. Wierzbicka, J.M., Żmijewski, M.A., Piotrowska, A., et al. “Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes.” Mol Cell Endocrinol 437 (2016): 312–22. DOI: 10.1016/j.mce.2016.08.006
  21. Haylen, B.T., Maher, C.F., Barber, M.D., et al. “An International Urogynecological Association (IUGA)/ International Continence Society (ICS) joint report on the terminology for female pelvic organ prolapse (POP).” Int Urogynecol J 27.4 (2016): 655–84. DOI: 10.1007/s00192-016-3003-y
  22. Farquhar, C.M., Sadler, L., Harvey, S.A., et al. “The Association of Hysterectomy and menopause: A prospective cohort study.” BJOG 112.7 (2005): 956–62. DOI: 10.1111/j.1471-0528.2005.00696.x
  23. Nappi, R.E., Kokot-Kierepa, M. “Women’s voices in the menopause: results from an international survey on vaginal atrophy.” Maturitas 67.3 (2010): 233–8. DOI: 10.1016/j.maturitas.2010.08.001
  24. Waetjen, L.E., Crawford, S.L., Chang, P.-Y., et al. “Factors associated with developing vaginal dryness symptoms in women transitioning through menopause: a longitudinal study.” Menopause 25.10 (2018): 1094–1104. DOI: 10.1097/gme.0000000000001130
  25. Waetjen, L.E., Johnson, W.O., Xing, G., et al. “Serum estradiol levels are not associated with urinary incontinence in midlife women transitioning through menopause.” Menopause 18.12 (2011): 1283–90. DOI: 10.1097/gme.0b013e31821f5d25
  26. Schulte-Uebbing, C., Schlett, S. “Vitamin D in der gynäkologischen Praxis. Ergebnisse einer Anwendungsbeobachtung.” CO MED 3 (2010): 1–3.
  27. Schulte-Uebbing, C., Schlett, S. “Kolpitis und Co. – vaginale Vitamin-D-Applikation hilft.” Gynäkologie und Geburtshilfe 3 (2010): 44–45.

Published

2022-08-10

How to Cite

Proshchenko, O., & Ventskivska, I. (2022). Efficiency of treatment and diagnostic algorithms in the rehabilitation program of women after hysterectomy with opportunist salpingectomy due to uterine myoma. REPRODUCTIVE ENDOCRINOLOGY, (66), 90–97. https://doi.org/10.18370/2309-4117.2022.66.90-97

Issue

Section

Tumors and pretumoral pathology