Cervical dysplasia: etiology, patogenesis, diagnosis and treatment

Authors

  • В. К. Кондратюк Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine, Ukraine
  • Н. Є. Горбань Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine, Ukraine
  • А. І. Нарольська Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine, Ukraine
  • А. О. Калюта Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2014.17.105-109

Keywords:

cervical dysplasia, cervical cancer, human papilloma virus, Epigalin

Abstract

Cervical dysplasia is precancerous diseases and may transform into cervical cancer in 30% of cases. Development of epithelial dysplasia and cervical cancer is closely associated with the activity of the human papilloma virus. Such processes are needed for the formation of irreversible neoplasia: induction of the mechanisms of metabolic conversion of estradiol into 16α-ONE1; active expression of human papillomavirus E6 and E7 oncogenes; induction of multiple lesions in the chromosomal DNA of the infected cell; enhancement of biological processes, mediating carcinogenesis. Over time, selection of cell clones containing the integrated viral DNA is formed into a malignant tumor. Epigalin is a promise natural drug with antitumor mechanism of action for the prevention and accompanying therapy of the cervical pathology.

Author Biographies

В. К. Кондратюк, Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine

MD, professor

Н. Є. Горбань, Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine

Кандидат медичних наук, науковий співробітник відділення планування сім’ї

А. І. Нарольська, Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine

аспірант відділення планування сім’ї

А. О. Калюта, Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine

Кандидат медичних наук, старший науковий співробітник відділення планування сім’ї

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Published

2014-07-11

How to Cite

Кондратюк, В. К., Горбань, Н. Є., Нарольська, А. І., & Калюта, А. О. (2014). Cervical dysplasia: etiology, patogenesis, diagnosis and treatment. REPRODUCTIVE ENDOCRINOLOGY, (17), 105–109. https://doi.org/10.18370/2309-4117.2014.17.105-109

Issue

Section

Tumors and pretumoral pathology

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