From research to clinical practice: viewpoint on the problem of thrombotic risks in the use of oral and nonoral combined hormonal contraceptives

Authors

  • Т. Ф Татарчук Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine, Ukraine
  • Т. Н. Тутченко Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine, Ukraine
  • Н. В. Яроцкая Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine, Ukraine

DOI:

https://doi.org/10.18370/2309-4117.2014.16.18-25

Keywords:

combined hormonal contraceptives, venous thromboembolism, relative risk, NuvaRing

Abstract

This paper is a review of contemporary scientific publications that deal with association of oral and non-oral forms of combined hormonal contraceptives with thrombotic events risk. Basing on the data analyzed, the following conclusion was made: in case of accurate adherence to medical eligibility criteria and adequate risk factors evaluation the use of combined hormonal contraceptives including vaginal ring NuvaRing leads to clinically nonsignificant thrombosis risk while the benefits of these medications overweigh risks of cardiovascular events.

Thus, the absolute risk of the use of combined hormonal contraceptives for women of reproductive age is extremely low (1-3 cases per 10 000 women). The risk of deaths as a result of venous thromboembolism while taking combined hormonal contraceptives is also low: the probability of death from venous thromboembolism is increased to 1 in 100 000 women if a relative risk level is 2. Increased risk of venous thromboembolism during pregnancy and the postpartum period are 29–30 cases per 10 000 women.

Author Biographies

Т. Ф Татарчук, Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine

MD, professor, corresponding member of NAMS of Ukraine, Deputy Director for Research Work, Chief of the Endocrine Gynecology Department

Т. Н. Тутченко, Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine

PhD, scientific researcher, Department of Endocrine Gynecology

Н. В. Яроцкая, Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine

Junior researcher, Department of Endocrine Gynecology

References

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Published

2014-07-11

How to Cite

Татарчук, Т. Ф., Тутченко, Т. Н., & Яроцкая, Н. В. (2014). From research to clinical practice: viewpoint on the problem of thrombotic risks in the use of oral and nonoral combined hormonal contraceptives. REPRODUCTIVE ENDOCRINOLOGY, (16), 18–25. https://doi.org/10.18370/2309-4117.2014.16.18-25

Issue

Section

Contraception

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