Evaluation of the efficiency and safety of long-term cimicifuga racemosa extract therapy in patients with climacteric syndrome

Authors

  • И. В. Рафаэлян Acad. V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Moscow, Russian Federation
  • В. Е. Балан Moscow Regional Research Institute of Obstetrics and Gynecology, Russian Federation
  • И. У. Юсупова V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Moscow, Russian Federation
  • Т. С. Филатова V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Moscow, Russian Federation
  • И. А. Ковалева V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Moscow, Russian Federation
  • Г. Б. Агаларзаде V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Moscow, Russian Federation

DOI:

https://doi.org/10.18370/2309-4117.2014.15.38-44

Keywords:

climacteric syndrome, neurotransmitters, Klimadynon

Abstract

To evaluate the efficiency and safety of long-term use of Klimadynon® based on an extract of the medicinal plant Cimicifuga racemosa (CR) for the treatment of climacteric syndrome (CS), 35 peri- and early postmenopausal women aged 45 to 60 years with moderate CS (Group 1) were examined. Group 2 consisted of 35 women of the same age with moderate CS who received placebo.

Comprehensive clinical and laboratory examination of the patients involved evaluation of the symptoms of CS, assessment of the results of hormonal examination, biochemical and lipid profile studies, small pelvic ultrasonography, Pipelle endometrial biopsy, mammography, and determination of the levels of major plasma and urinary neutrotransmitters. Therapy with the drug containing a CR extract was ascertained to be significantly more effective than placebo. Additional positive lipid spectrum changes and no hepatotoxicity were found.

Author Biographies

И. В. Рафаэлян, Acad. V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Moscow

Graduate student

В. Е. Балан, Moscow Regional Research Institute of Obstetrics and Gynecology

MD, professor

И. У. Юсупова, V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Moscow

PhD

Т. С. Филатова, V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Moscow

PhD

И. А. Ковалева, V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Moscow

PhD

Г. Б. Агаларзаде, V.P. Serbsky State Research Center for Social and Forensic Psychiatry, Moscow

PhD

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Published

2014-07-10

Issue

Section

Management of menopause