Hypomenstrual syndrome in adolescent girls as a result of reproductive dysfunction in their mothers

Literature review





menstrual disorders, reproductive dysfunction, hypomenstrual syndrome, oligomenorrhea, amenorrhea, adolescent girls


In recent years in Ukraine and in the world there has been a clear tendency towards deterioration in the indicators of the somatic health of children and adolescents, that is negatively affects the processes of reproductive health formation and it state in the future.
Concern for adolescent girl's health, including their reproductive system, forms an enormous contribution to the society future. That's why big attention is paid to the formation and saving reproductive health of adolescent girls. The period of sexual development is defining in a woman's life and is considered a key moment on the path of reproductive maturity. Today it has been established that the reproductive health formation is influenced by environmental, socio-economic factors and the presence of somatic diseases. Despite the fact that the pathogenetic mechanisms of the reproductive system formation are extremely complex and sensitive to the effects of negative factors, the appearance of destructive factors at this time can disrupt the physiological chain of functioning of the hormonal mechanisms which regulate the reproductive system. Disorders of the menstrual cycle is one of the most common pathological conditions, combining pathogenetically different diseases, which are manifested by a violation of the menstrual duration and frequency, amount of menstrual flow. According to domestic literature, hypomenstrual syndrome (oligomenorrhea, amenorrhea) is in the first place among menstrual dysfunctions in adolescent girls in the structure of gynecological morbidity and is up to 45%. Menstrual irregularities that occur during adolescence often persist into the future, causing infertility, obstetric pathology, perinatal loss and other reproductive health problems during childbearing years. The problem of the menstrual cycle formation has been little studied, but it is socially significant, very relevant and requires further study.
Thus, girls with menstrual disorders constitute a group of increased risk of gynecological diseases in women of reproductive age, since many chronic diseases of adults are a protracted pathology of adolescents. Therefore, adolescent girls should be examined and treated by a specialist in pediatric and adolescent gynecology, pediatric endocrinologist, pediatrician and family doctor.

Author Biographies

V.V. Artyomenko, Odesa National Medical University, Odesa

MD, PhD, DSc(Med), professor, Department of Obstetrics and Gynecology

N.M. Nastradina, Odesa National Medical University, Odesa

PhD, associate professor, Department of Obstetrics and Gynecology

K.O. Nitochko, Odesa National Medical University, Odesa

PhD, associate professor, Department of Obstetrics and Gynecology

M.A. Altyieva, Odesa National Medical University, Odesa

Clinical resident, Department of Obstetrics and Gynecology


  1. Adams Hillard, P.J. “Menstruation in young girls: a clinical perspective.” Obstet Gynecol 99 (2002): 655–62.
  2. Andreeva, V.O., Botasheva, T.L., Rymashevskiy, A.N., et. al. “The role of melatonin and inhibin B in the pathogenesis of oligomenorrhea in adolescent girls.” Pediatric and Adolescent Reproductive Health 16.3 (2020): 56–63.
  3. Andreeva, V.O., Mashtalova, A.A. “The role of apoptosis factors in the pathogenesis of oligomenorrhea and uterine bleeding during puberty.” Bulletin of St Petersburg University 11.4 (2011): 69–80.
  4. Babenko-Skoropud, I.V., Yakovleva, E.B., Sorokopud, E.P., et.al. “Ways to optimize the reproductive health of adolescent girls, taking into account the data of the Donetsk region.” Pediatric and Adolescent Reproductive Health 15.4 (2019): 17–24.
  5. Bagatska, N.V., Demenkova, I.G., Nachotova, T.A. “Burdened family history – a risk factor for the formation of menstrual disorders in adolescent girls.” Bulletin of Karazin Kharkiv National University. Biology series 27.1 (2016): 39–45.
  6. Bugun, O.V., Khramova, E.E., Pigareva, L.N., et.al. “Features of the state of the vagina and cervix microbiocenosis in adolescent girls with menstrual irregularities.” (II Scientific-practical conference with international participation “National and international experience in protecting the reproductive health of children and adolescents”). Pediatric and Adolescent Reproductive Health 2 (2016): 58–9.
  7. Tsysar, Y.V. “Peculiarities of puberty in girls with menstrual dysfunction.” Bukovinian Medical Herald 22.2 (2018): 109–12.
  8. Comim, F.V., Wippel, C.S., Copês, R.M., et al. “Higher prevalence of clinical cardiovascular comorbidities in postmenopausal women with self-reported premenopausal hirsutism and/or oligo-amenorrheа.” Dermatoendocrinol 9.1 (2017): e1356517.
  9. Dvoryansky, S.A., Emelyanova, D.I. “Obesity and Women's Reproductive Health.” Vyatka Medical Bulletin 2.66 (2020): 83–7.
  10. Geum, J.C., Sung, W.H., Jung-Ho, S., Tak, K. “Effects of intensive training on menstrual function and certain serum hormones and peptides related to the female reproductive system.” Medicine (Baltimore) 96.21 (2017): 6876.
  11. Gorbunova, O.V., Yurchenko, I.O. “A predictive analysis of daily progress to the correction of hyperprolactinemia in children with impaired menstrual functions.” Reproductive Endocrinology 5 (2020): 42–7.
  12. Govorukha, I.T., Zheleznaya, A.A., Yakovleva, E.B. “Young motherhood and its consequences.” Materials of the XIX All-Russian Scientific and Educational Forum “Mother and Child-2018” (2018): 13.
  13. Gryshchenko, O.V., Bobrytska, V.V. “New patterns of menstrual disorder's treatment – unification of the method.” Reproductive Endocrinology 3.47 (2019): 26–32.
  14. Gurkin, Y.A. “The concept of “perinatal trace” in pediatric gynecology.” Bukovinian Medical Herald 2 (2001): 56–7.
  15. Hickey, R.J., Zhou, X., Settles, M.L., et al. “Vaginal microbiota of adolescent girls prior to the onset of menarche resemble those of reproductive-age women.” mBio 6.2 (2015): 00097–15.
  16. Iacovides, S., Avidon, I., Baker, F.C. “What we know about primary dysmenorrhea today: a critical review. Review article.” Hum Reprod Update 21.6 (2015): 762–78.
  17. Kalsi, A.K., Halder, A., Jain, M. “Prevalence and reproductive manifestations of macroprolactinemia.” Endocrine 63 (2019): 332–40.
  18. Kashkalda, D.A., Levenets, S.A., Nachetova, T.A., Kulinich, T.M. “The level of leptin and features of the lipid spectrum of blood in adolescent girls with oligomenorrhea and secondary amenorrhea.” Reproductive Endocrinology 3.5 (2012): 32–5.
  19. Kolesnik, M. “HMS in adolescent girls: pathogenesis, prevention, long-term consequences.” Ukrainian medical journal 3 (2017): 16–9.
  20. Kuznetsova, I.V., Uspenskaya, Y.B., Dil, V.V., Grineva, A.M. “Use of herbal dopaminomimetics in adolescents and young women with irregular menstrual cycles.” Obstetrics and gynecology 10 (2015): 52–8.
  21. Levenets, S.A., Nachotova, Т.А., Verkhoshanova, О.G., et.al. “Reproductive function of mothers of girls with HMS.” Obstetrics. Gynecology. Genetics 3.3 (2017): 53–5.
  22. Levenets, S.A., Udovikova, N.A. “Clinical features of adolescent girls with HMS associated with underweight. Supplement to the materials of the III Scientific-practical conference with international participation “National and international experience in protecting the reproductive health of children and youth” (April 16–18, 2019, Moscow).” Pediatric and Adolescent Reproductive Health 15.4 (2019).
  23. Levenets, S.O., Nachotova, T.A., Udovikova, N.O., Novokhatskaya, S.V. “Prevention of oligomenorrhea and secondary amenorrhea in adolescent girls.” Ukrainian Journal of Pediatric Endocrinology 2 (2017): 29–33.
  24. Mazur, L.P., Marushchak, M.I., Naumova, L.V. “A clinical case of hyperprolactinemia combined with an increase in thyroid-stimulating hormone.” Bulletin of medical and biological research 2 (2019): 87–9.
  25. Nachotova, T.A., Belyaeva, E.E., Udovikova, N.A., Kashkalda, D.A. “Psychological features of adolescent girls with oligomenorrhea and secondary amenorrhea and their dependence on levels of stress-releasing hormones.” International Journal of Pediatrics, Obstetrics and Gynecology 12.1 (2018): 59–63.
  26. Nachotova, T.A. “Secondary amenorrhea in adolescent girls (clinical and hormonal-metabolic aspects, pathogenesis, diagnosis and treatment)”: Thesis for the doctor degree of medical sciences. Kharkiv (2016): 320 p.
  27. Orio, F. “Effects of physical exercise on the female reproductive system.” Minevra Endocrinol 38.3 (2013): 305–19.
  28. Pankiv, V.I. “The influence of thyroid disorders upon the female reproductive function. Modern possibilities of phytotherapy.” Reproductive Endocrinology 1.27 (2016): 52–7. DOI: 10.18370/2309-4117.2016.27.52-57
  29. Seidenfeld, M.E., Rickert, V.I. “Impact of anorexia, bulimia and obesity on the gynecologic health of adolescents.” Am Fam Physician 64.3 (2001): 445–50.
  30. Tatarchuk, T., Zakharenko, N., Bachynska, I., Kosey, N. “On the issue of autoimmune ovary damage during puberty”. Georgian Med News 279 (2018): 49–56.
  31. Tencer, J., Lemaire, P., Brailly-Tabard, S., Brauner, R. “Serum Inhibin B Concentration as a Predictor of Age at First Menstruation in Girls With Idiopathic Central Precocious Puberty.” PLoS One 13.12 (2018): 2058.
  32. Udovikova, N.A. “Features of therapy of adolescent girls with primary oligomenorrhea.” Obstetrics. Gynecology. Genetics 3.3 (2017): 59–62.
  33. Uvarova, E.V., Batyrova, Z.К., Latypova, N.K. “Features of microbiocenosis of the mucous membrane of the vagina in girls with vulvovaginitis when using moleсular genetic diagnostic methods.” Pediatric and Adolescent Reproductive Health 4 (2014): 42–8.
  34. Uvarova, E.V., Latypova, N.K., Muravyova, N.A., et.al. “Age features of the diagnosis and treatment of bacterial vaginosis in childhood and adolescence.” Russian Bulletin of Obstetrician-Gynecologist 4 (2006): 57–61.
  35. Uvarova, E.V., Sultanova, F.S., Latypova, N.K. “The vagina as a microecosystem in normal conditions and in inflammatory processes of various etiologies.” Pediatric and Adolescent Reproductive Health 2 (2005): 26–38.
  36. Vale, B., Brito, S., Paulos, L., Moleiro, P. “Menstruation disorders in adolescents with eating disorders-target body mass index percentiles for their resolution.” Einstein (Sao Paulo, Brazil) 12.2 (2014): 175–80.
  37. Voropaeva, N.M., Nemchenko, U.M., Grigorova, E.V., et.al. “Microecological features of the vaginal biotope in teenage girls with menstrual disorders.” Pediatric and Adolescent Reproductive Health 1 (2018): 37–44.
  38. Vovk, I.B., Kornatska, A.G., Petersburzka, V.F. “Normalization of menstrual disorders in adolescent girls is the key to maintaining reproductive health in women.” Health of Ukraine 2 (2019): 27–35.
  39. World Health Organization. International Statistical Classification of Diseases and Related Health Problems of the Tenth Review (ICD-10). Geneva. May 23, 2019.
  40. Yakovleva, E.B., Babenko-Sorokopud, I.V., Zheltonozhenko, L.V., Vustenko, V.V. “Features of ovarian reserve in adolescent girls against the background of a period of intensive growth with secondary amenorrhea.” Medical and Social Problems of Family 23.1 (2018): 35–40.




How to Cite

Artyomenko, V., Nastradina, N., Nitochko, K., & Altyieva, M. (2021). Hypomenstrual syndrome in adolescent girls as a result of reproductive dysfunction in their mothers: Literature review. REPRODUCTIVE ENDOCRINOLOGY, (61), 66–70. https://doi.org/10.18370/2309-4117.2021.61.66-70