A contemporary view on obesity treatment in adults

Literature review





overweight, obesity, body mass index, liraglutide, naltrexone, bupropion, orlistat


Today, the prevalence of overweight and obesity is pandemic. This disorder is defined as “a complex chronic disease in which abnormal or excess body fat impairs health, increases the risk of long-term medical complications, and decreases life expectancy”.
This article presents evidence-based clinical guidelines for the management of obese patients, as well as excerpts comments on pharmacological treatment.
Treatment approaches for overweight and obese patients include behavioral interventions, lifestyle adjustments, etc. One of the methods is pharmacological therapy, based on the following principles: therapy for weight loss can be used starting already at a body mass index ≥ 27 kg/m2 or ≥ 30 kg/m2 with complications associated with excess body fat. As drugs can be used liraglutide, combination of naltrexone + bupropion, orlistat. Pharmacotherapy must be accompanied by lifestyle modification, including if necessary therapeutic diet, increased physical activity on ongoing basis with its mandatory control, and behavioral or cognitive-behavioral therapy. Pharmacotherapy can be used to support the weight loss achieved through lifestyle modifications and to prevent weight gain. It is forbidden to use over-the-counter drugs unless they are approved for weight control. Patients with metabolic obesity should be consulted by specialists to assess the feasibility of bariatric surgery, followed by treatment with this specialist.
Every clinician must have sufficient knowledge to diagnose obesity and offer their patients an individualized, long-term, evidence-based weight loss regimen. The success of obesity treatment depends on the patient's trust the doctor and on the doctor's knowledge in this area.

Author Biographies

V.I. Velychko, Odesa National Medical University, Odesa

MD, professor, head of the Department of Family Medicine, chairman of the Association of Family Medicine of the Odesa Region

B.M. Mankovskyi, P.L. Shupyk National University of Health of Ukraine, Kyiv

MD, professor, corresponding member of the NAMS of Ukraine, head of the Department of Diabetology

T.F. Tatarchuk, SI “O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”; State Scientific Institution “Center for Innovative Medical Technologies of the NAS of Ukraine”, Kyiv

MD, professor, corresponding member of the NAMS of Ukraine, deputy director for research work, head of the Endocrine Gynecology Department;
Chief researcher, Department of Reproductive Health

D.O. Lahoda, Odesa National Medical University, Odesa

Assistant, Department of Family Medicine

I.M. Todurov, State Scientific Institution “Center for Innovative Medical Technologies of the NAS of Ukraine”, Kyiv

MD, professor, director

O.M. Lishchyshyna, State Scientific Institution “Scientific and Practical Center for Preventive and Clinical Medicine” of the State Management of Affairs, Kyiv

PhD, senior researcher, head of the Scientific Department of Medical Care Organization


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How to Cite

Velychko, V., Mankovskyi, B., Tatarchuk, T., Lahoda, D., Todurov, I., & Lishchyshyna, O. (2021). A contemporary view on obesity treatment in adults: Literature review. REPRODUCTIVE ENDOCRINOLOGY, (61), 45–50. https://doi.org/10.18370/2309-4117.2021.61.45-50