Reproductive health of parents

Literature review


  • O.M. Yuzko Ukrainian Association of Reproductive Medicine; Bukovinian State Medical University; Medical Center for Infertility Treatment, Chernivtsi, Ukraine



reproductive health, myo-inositol, folic acid, congenital malformations


The reproductive health of parents is the onset and further physiological course of pregnancy, childbirth and health of the unborn child. Saving of reproductive health can be considered as protecting the family from factors with “reproductive toxicity”, that is lead to morphological and functional changes in the germ cells, organs and systems of embryo. The risk of infertility and miscarriage is significantly higher in couples where a man and a woman have balanced chromosomal rearrangements or gene polymorphisms. In the future, we will be able to block genotoxic lesions of the genome at the gene level.
Research and development of experience on this issue continues. Now there are already some promising methods, which include nutritional support at the stage of pregnancy planning using folic acid and myo-inositol. New guidelines have been developed for folic acid, metafolin, MTHFR gene variants, and others. Neural tube defects are more common in people with MTHFR 677 CT and TT genotypes in countries where food folate fortification is not used, so they did not get enough of it. Women who are planning a pregnancy and have previously children with malformations are recommended to intake folic acid 4000 µg daily, starting 1 month before pregnancy and during the first 3 months of gestation.
However, getting ready for pregnancy is much more than 3 or 12 months before conception. Preparing for pregnancy is a healthy lifestyle for parents from the moment they are conceived to their reproductive years. Saving of reproductive health is protection against genotoxic damage. Genotoxic substances act in different periods of life with different intensity of strength and time, therefore, the program for maintaining reproductive health should begin from the moment of conception of future parents. At the same time, the reproductive health saving program applies to both women and men.

Author Biography

O.M. Yuzko, Ukrainian Association of Reproductive Medicine; Bukovinian State Medical University; Medical Center for Infertility Treatment, Chernivtsi

MD, professor, president of the Ukrainian Association of Reproductive Medicine;
Head of the Department of Obstetrics and Gynecology;
Head doctor


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How to Cite

Yuzko, O. (2021). Reproductive health of parents: Literature review. REPRODUCTIVE ENDOCRINOLOGY, (60), 72–76.



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