Injection methods of penis enlargement
DOI:
https://doi.org/10.18370/2309-4117.2021.59.110-115Keywords:
penis enlargement, penis plastic surgery, fillers, micropenis, small penis syndromeAbstract
Review objective: to evaluate the current scientific evidence of all available injectable methods of penis enlargement, to evaluate their effectiveness.
Materials and methods. A systematic search of scientific medical information include databases MEDLINE, Embase, AMED and HMIC. A manual web search of relevant links in the found texts was performed.
Results. Conditions in which phallus thickening is used: concern with penis size or small penis syndrome, penile dysmorphophobia, penis reduction (radical prostatectomy for prostate cancer, Peyronie's disease, congenital anomalies, erectile dysfunction).
Injectable thickening of penis started using in the in the early XX century, paraffin and mineral oils were introduced. In the 1940s, safer liquid silicone and polymethyl methacrylate were used. Gel-like biodegradable materials are currently popular because they lack most of the disadvantages of permanent substances: hyaluronic acid, polylactic acid, dextran gel and mixtures of these substances. Thickening of the penis depends on the volume inserted filler and averages + 2–4 cm in circumference.
In 2003, Moon et al. for the first time proposed a method of enlarging the penis head with hyaluronic acid. Other drugs were also used: hydrogel, polyacrylamide and dextran gel. Hyaluronic acid is the most commonly used drug. Promising filler is polylactic acid, which stimulates the fibroblasts development at the injection site and is relatively safe to use. The circumference length of the penis head can be increased by an average of 1.5 cm.
Conclusion. Penis enlargement procedures are gaining popularity among men. However, there are a limited number of scientific papers that would describe the results and complications of these procedures. Further research is needed to study the impact of penis enlargement techniques on men's sex life and well-being, because it is the key motivating factor in turning to experts on this issue.
References
- Dillon, B.E., Chama, N.B., Honig, S.C. “Penile size and penile enlargement surgery: A review.” Int J Impot Res 20 (2008): 519–29. DOI: 10.1038/ijir.2008.14
- Friedman, D.M. A Mind of Its Own: A Cultural History of the Penis. Robert Hale (2009); 2001. DOI: 10.5860/choice.39-5875
- Roos, H., Lissoos, I. “Penis lengthening.” Int J AesthRestor Surg 2 (1994): 89–96.
- Hehemann, M.C., Towe, M., Huynh, L.M., et al. “Penile Girth Enlargement Strategies: What’s the Evidence?” Sex Med Rev 7 (2019): 535–47. DOI: 10.1016/j.sxmr.2018.11.003
- Boiko, M.I., Chornokulskyi, I.S., Boiko, O.M. “Elongation of human penis. New method of skin plasty.” Urology and reproductive medicine 82 (2019): 36–46.
- Boiko, M.I., Chornokulskyi, I.S., Boiko, O.M. “New method of skin plasty during penile elongation.” Plastic, Reconstructive and Estetic Surgery (2019): 47–57.
- Kelley, J.H., Eraklis, A.J. “A procedure for lengthening the phallus in boys with exstrophy of the bladder.” J Pediatr Surg 6 (1971): 645–9. DOI: 10.1016/0022-3468(71)90391-5
- Lever, J., Frederick, D.A., Peplau, L.A. “Does size matter? Men’s and women’s views on penis size across the lifespan.” Psychol Men Masculinity 7 (2006): 129–43. DOI: 10.1037/1524-9220.7.3.129
- Francken, A.B., Van de Wiel, H.B.M., Van Driel, M.F., Weijmar Schultz, W.C.M. “What importance do women attribute to the size of the penis?” Eur Urol 42 (2002): 426–31. DOI: 10.1016/S0302-2838(02)00396-2
- Davoudzadeh, E.P., Davoudzadeh, N.P., Margolin, E., et al. “Penile Length: Measurement Technique and Applications.” Sex Med Rev (2017). DOI: 10.1016/j.sxmr.2017.10.002
- Tran, H., Goldfarb, R., Ackerman, A., Valenzuela, R.J. “Penile Lengthening, Girth, and Size Preservation at the Time of Penile Prosthesis Insertion.” Sex Med Rev 5 (2017): 403–12. DOI: 10.1016/j.sxmr.2016.11.005
- Marra, G., Drury, A., Tran, L., et al. “Systematic Review of Surgical and Nonsurgical Interventions in Normal Men Complaining of Small Penis Size.” Sex Med Rev (2019). DOI: 10.1016/j.sxmr.2019.01.004
- Mondaini, N., Ponchietti, R., Gontero, P., et al. “Penile length is normal in most men seeking penile lengthening procedures.” Int J Impot Res 14 (2002): 283–6. DOI: 10.1038/sj.ijir.3900887
- Campbell, J., Gillis, J. A review of penile elongation surgery. Vol. 6. AME Publishing Company (2017). DOI: 10.21037/tau.2016.11.19
- Patent for useful model No. 117128 Ukraine, IPC (2017.01) A61B 17/00. Method for surgically increasing penis length / Boiko M.I., Chornokulsky I.S., Boiko O.M.; applicant and patentee SSI “Research and Practical Center of Preventive and Clinical Medicine” State Management of Affairs, No. u 2017 01242; appl. 10.02.2017; publ. 12.06.2017, Bull. Number 11.
- Patent for useful model No. 117889 Ukraine, IPC (2006) A61B 17/00. Method of surgical penile elongation / Boiko M.I., Chornokulsky I.S., Boiko O.M.; applicant and patentee SSI “Research and Practical Center of Preventive and Clinical Medicine” State Management of Affairs, No. u 2017 01244; appl. 10.07.2017; publ. 10.07.2017, Bull. Number 13.
- Patent for useful model No. 119081 Ukraine, IPC (2006) A61B 17/00. Method for surgical correction of penis length / Boiko M.I., Chornokulsky I.S., Boiko O.M.; applicant and patentee SSI “Research and Practical Center of Preventive and Clinical Medicine” State Management of Affairs, No. u 2017 02939; appl. 28.03.2017; publ. 11.09.2017, Bull. Number 17.
- Patent for useful model No. 118697 Ukraine, IPC (2006) A61B 17/00. Method for surgical elongation of penile length / Boiko M.I., Chornokulsky I.S.; applicant and patentee SSI “Research and Practical Center of Preventive and Clinical Medicine” State Management of Affairs, No. u 2017 01200; appl. 28.03.2017; publ. 28.08.2017, Bull. Number 16.
- Boiko, M. “P-01-043 Penile elongation: A new surgery plastic skin procedure in patients with penile dysmorphophobia.” J Sex Med 14 (2017): e173. DOI: 10.1016/j.jsxm.2017.03.175
- Ghanem, H., Glina, S., Assalian, P., Buvat, J. “Position Paper: Management of Men Complaining of a Small Penis Despite an Actually Normal Size.” J Sex Med 10 (2013): 294–303. DOI: 10.1111/j.1743-6109.2012.02725.x
- American Psychiatric Association. Diagnostic and statistical mental disorders manual of fifth edition (DSM-5). Vol. 17. 5th ed. Arlington, VA. American Psychiatric Publishing (2013).
- Oates, J., Sharp, G. “Nonsurgical Medical Penile Girth Augmentation: Experience-Based Recommendations.” Aesthetic Surg J 37 (2017): 1032–8. DOI: 10.1093/asj/sjx068
- Sarwer, D.B., Spitzer, J.C. “Body image dysmorphic disorder in persons who undergo aesthetic medical treatments.” Aesthetic Surg J 32 (2012): 999–1009. DOI: 10.1177/1090820X12462715
- Wylie, K.R., Eardley, I. “Penile size and the ‘small penis syndrome’.” BJU Int 99 (2007): 1449–55. DOI: 10.1111/j.1464-410X.2007.06806.x
- Veale, D., Miles, S., Read, J., et al. “Sexual Functioning and Behavior of Men with Body Dysmorphic Disorder Concerning Penis Size Compared with Men Anxious about Penis Size and with Controls: A Cohort Study.” Sex Med 3 (2015): 147–55. DOI: 10.1002/sm2.63
- Phillips, K.A., Coles, M.E., Menard, W., et al. “Suicidal Ideation and Suicide Attempts in Body Dysmorphic Disorder.” J Clin Phsychiatry 66.6 (2005): 717–25. DOI: 10.4088/jcp.v66n0607
- Veale, D., Anson, M., Miles, S., et al. “Efficacy of cognitive behaviour therapy versus anxiety management for body dysmorphic disorder: A randomised controlled trial.” Psychother Psychosom 83 (2014): 341–53. DOI: 10.1159/000360740
- Veale, D., Gournay, K., Dryden, W., et al. “Body dysmorphic disorder: A cognitive behavioural model and pilot randomised controlled trial.” Behav Res Ther 34 (1996): 717–29. DOI: 10.1016/0005-7967(96)00025-3
- Wilhelm, S., Phillips, K.A., Didie, E., et al. “Modular cognitive-behavioral therapy for body dysmorphic disorder: A randomized controlled trial.” Behav Ther 45 (2014): 314–27. DOI: 10.1016/j.beth.2013.12.007
- Phillips, K.A., Albertini, R.S., Rasmussen, S.A. “A randomized placebo-controlled trial of fluoxetine in body dysmorphic disorder.” Arch Gen Psychiatry 59 (2002): 381–8. DOI: 10.1001/archpsyc.59.4.381
- Veale, D., Miles, S., Read, J., et al. “Penile Dysmorphic Disorder: Development of a Screening Scale.” Arch Sex Behav 44 (2015): 2311–21. DOI: 10.1007/s10508-015-0484-6
- Moon, D.G., Kwak, T.I., Cho, H.Y., et al. “Augmentation of glans penis using injectable hyaluronic acid gel.” Int J Impot Res 15 (2003): 456–60. DOI: 10.1038/sj.ijir.3901058
- Moon, D.G., Kwak, T.l., Kim, J.J. “Glans Penis Augmentation Using Hyaluronic Acid Gel as an Injectable Filler.” World J Mens Health 33 (2015): 50. DOI: 10.5534/wjmh.2015.33.2.50
- Ahn, S.T., Kwak, T.l., Park, K.S., et al. “Complications of glans penis augmentation.” Int J Impot Res 31 (2019): 245–55. DOI: 10.1038/s41443-018-0097-4
- Kwak, T.I., Jin, M.H., Kim, J.J., Moon, D.G. “Long-term effects of glans penis augmentation using injectable hyaluronic acid gel for premature ejaculation.” Int J Impot Res 20 (2008): 425–8. DOI: 10.1038/ijir.2008.26
- Kim, J.J., Kwak, T.I., Jeon, B.G., et al. “Effects of glans penis augmentation using hyaluronic acid gel for premature ejaculation.” Int J Impot Res 16 (2004): 547–51. DOI: 10.1038/sj.ijir.3901226
- Perovic, S.V., Radojicic, Z.I., Djordjevic, M.L., Vukadinovic, V.V. “Enlargement and sculpturing of a small and deformed glans.” J Urol 170 (2003): 1686–90. DOI: 10.1097/01.ju.0000084431.99013.13
- Shaeer, O. “Supersizing the Penis Following Penile Prosthesis Implantation.” J Sex Med 7 (2010): 2608–16. DOI: 10.1111/j.1743-6109.2010.01723.x
- Yang, D.Y., Ko, K., Lee, S.H., et al. “Efficacy and safety of newly developed cross-linked dextran gel injection for glans penis augmentation with a novel technique.” Asian J Androl 20 (2018): 80–4. DOI: 10.4103/aja.aja_1_17
- Abdallah, H., Abdelnasser, T., Hosny, H., et al. “Treatment of premature ejaculation by glans penis augmentation using hyaluronic acid gel: A pilot study.” Andrologia 44 (2012): 650–3. DOI: 10.1111/j.1439-0272.2011.01244.x
- Kim, J.J., Kwak, T.I., Jeon, B.G., et al. “Human glans penis augmentation using injectable hyaluronic acid gel.” Int J Impot Res 15 (2003): 439–43. DOI: 10.1038/sj.ijir.3901044
- Vardi, Y., Harshai, Y., Gil, T., et al. “A Critical Analysis of Penile Enhancement Procedures for Patients with Normal Penile Size: Surgical Techniques, Success, and Complications.” Eur Urol 54 (2008): 1042–50. DOI: 10.1016/j.eururo.2008.07.080
- Bizic, M.R., Djordjevic, M.L. “Penile Enhancement Surgery: an Overview.” Cit EMJ Urol 4 (2016): 94–100.
- Eandi, J.A., Yao, A.P., Javidan, J. “Penile paraffinoma: The delayed presentation.” Int Urol Nephrol 39 (2007): 553–5. DOI: 10.1007/s11255-006-9058-9
- Orentreich, D.S. “Liquid injectable silicone: techniques for soft tissue augmentation.” Clin Plast Surg 27 (2000): 595–612.
- Silberstein, J., Downs, T., Goldstein, I. “Penile injection with silicone: Case report and review of the literature.” J Sex Med 5 (2008): 2231–7. DOI: 10.1111/j.1743-6109.2008.00911.x
- Yacobi, Y., Tsivian, A., Grinberg, R., Kessler, O. “Short-term results of incremental penile girth enhancement using liquid injectable silicone: Words of praise for a change.” Asian J Androl 9 (2007): 408–13. DOI: 10.1111/j.1745-7262.2007.00262.x
- Sasidaran, R., Mat Zain, M.A., Basiron, N.H. “Low-grade liquid silicone injections as a penile enhancement procedure: Is bigger better.” Urol Ann 4 (2012): 181–6. DOI: 10.4103/0974-7796.102672
- Casavantes, L., Lemperle, G., Morales, P. “Penile Girth Enhancement With Polymethylmethacrylate-Based Soft Tissue Fillers.” J Sex Med 13 (2016): 1414–22. DOI: 10.1016/j.jsxm.2016.06.008
- Kwak, T.l., Oh, M., Kim, J.J., Moon, D.G. “The Effects of Penile Girth Enhancement using Injectable Hyaluronic Acid Gel, a Filler.” J Sex Med 8 (2011): 3407–13. DOI: 10.1111/j.1743-6109.2010.01748.x
- Yang, D.Y., Jeong, H.C., Ahn, S.T., et al. “A Comparison Between Hyaluronic Acid and Polylactic Acid Filler Injections for Temporary Penile Augmentation in Patients with Small Penis Syndrome: A Multicenter, Patient/Evaluator-Blind, Comparative, Randomized Trial.” J Sex Med 17 (2020): 133–41. DOI: 10.1016/j.jsxm.2019.10.006
- Yang, D.Y., Ko, K., Lee, S.H., Lee, W.K. “A Comparison of the Efficacy and Safety Between Hyaluronic Acid and Polylactic Acid Filler Injection in Penile Augmentation: A Multicenter, Patient/Evaluator-Blinded, Randomized Trial.” J Sex Med 16 (2019): 577–85. DOI: 10.1016/j.jsxm.2019.01.310
- Bartus, C., William Hanke, C., Daro-Kaftan, E. “A decade of experience with injectable poly-l-lactic acid: A focus on safety.” Dermatologic Surg 39 (2013): 698–705. DOI: 10.1111/dsu.12128
- Yang, D.Y., Lee, W.K., Kim, S.C. “Tolerability and efficacy of newly developed penile injection of cross-linked dextran and polymethylmethacrylate mixture on penile enhancement: 6 months follow-up.” Int J Impot Res 25 (2013): 99–103. DOI: 10.1038/ijir.2012.41
- Patent for useful model No. 147422 Ukraine, IPC (2021.01) AA61B 17/00 A61M 1/00. Test system for determining the circumference length of the penile shaft when injecting the filler / Boiko M.I., Notsek M.S.; applicant and patentee SSI “Research and Practical Center of Preventive and Clinical Medicine” State Management of Affairs, No. u 2020 07951; appl. 14.12.2020; publ. 05.05.2021, Bull. Number 18.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 М.І. Бойко, М.С. Ноцек
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.