Application areas of modern automated methods of anti-Müllerian hormone evaluation

Literature review

Authors

DOI:

https://doi.org/10.18370/2309-4117.2021.59.85-91

Keywords:

premature menopause, ovarian reserve, granulosa cell tumors, polycystic ovary syndrome, functional hypothalamic amenorrhea, delayed sexual development

Abstract

Anti-Müllerian hormone (AMН) is a glycopeptide of the transforming growth factors β-family, used in many medical fields. Understanding of the biological role of AMH at norm and at pathology such as polycystic ovary syndrome (PCOS) is expanding. This review includes the literature analysis on the synthesis and biological role of AMH in women and men; factors influencing its level; possibilities and limitations of clinical use of AMH in pediatric endocrinology/urogynecology, reproductive medicine, diagnosis of PCOS and other dyshormonal conditions, oncofertility programs and diagnosis of genital tumors.
Effects of AMH in women: inhibiting the entry of primordial follicles into growth, control of follicle sensitivity to follicle-stimulating hormone, participation in the selection of the dominant
follicle, inhibition of aromatase activity in granulosa cells of the follicle, regulation of the gonadotropic generator of gonadotropic releasing hormone.
AMH is an important component of predicting the response to ovulation stimulation in infertile women, diagnosis of nonclassical forms of PCOS, premature ovarian failure to the development
of amenorrhea, other hormonal diseases, granulosa cell tumors, decisions about the possibility of maintaining reproductive function after cancer treatment. Currently, AMH cannot be used as
a tool for individualized prediction of the age of menopause, fertility. It is not recommended to decide on the use of cryotechnologies based only on the AMH level.
Evolution of laboratory estimation of АМН as an important factor of impact on clinical and scientific application of research is also considered. Despite significant improvements in the
technical characteristics of test systems for determining the AMH level, there are limitations in the use of this diagnostic marker due to the lack of standardization. This shortcoming can be
overcome by following principles: do not base important clinical decisions only at the AMH level, and use this indicator in conjunction with other laboratory parameters and clinical data;
adhere to the consistent use of one automated test system until the introduction of the standard in laboratory practice.

Author Biographies

O.A. Burka, Bogomolets National Medical University; “DILA” Medical Laboratory, Kyiv

PhD, associate professor at the Obstetrics and Gynaecology Department No. 1;

Scientific consultant

T.M. Tutchenko, SI “O.M. Lukyanova IPOG of the NAMS of Ukraine”; SSI “CIMT of the NAS of Ukraine»; “DILA” Medical Laboratory, Kyiv

PhD, senior researcher of the Endocrine Gynecology Department;

Department of Reproductive Health;

Scientific consultant

O.M. Kudlai, Military unit, Kyiv

PhD, obstetrician-gynecologist, head of the gynecological department

T.V. Shevchuk, Medical Club GRACE Clinic, Kyiv

PhD, endocrinologist-gynecologist

O.V. Protsenko, Regional Endocrinological Centre, Chernivtsi

Obstetrician gynecologist

O.M. Makarovets, Regional Perinatal Centre of Rivne City Council, Rivne

Obstetrician gynecologist

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Published

2021-07-22

Issue

Section

Gynecology