Problems of primary fallopian tube cancer diagnostics during and after surgery
Keywords:primary fallopian tube cancer, laparoscopy, laparotomy, suboperative diagnosis
To date, the reliable diagnoses primary fallopian tube cancer (PFTC) before surgery range from 0% to 10–15%. Number of misdiagnosis even during operations reaches 30–50% and PFTC is often disguised as innocent hydro-hematosalpinx or other diseases.
Research objective: to study the possibilities of PFTC diagnosis during laparotomy and laparoscopy, macroscopic examination of removed macrodrugs, suboperative use of morphological studies, problems of histological interpretation of PFTC after surgery.
Materials and methods. During the period from 1966 to 2020 authors of article selected and retrospectively studied quite informative medical histories of 105 patients with PFTC aged 34 to 78 years (mean age 55.8 years). All patients were operated. Revision of the pelvic organs and abdominal cavity was performed during operations. Removed macrodrugs were examined macroscopically and histologically. According to the indications during operations histological and cytological methods of rapid diagnosis were used. Immunohistochemical methods were used to interpret rare and difficult to diagnose tumors after surgery.
Results. Only 7 (6.6%) from 105 patients with PFTC was not recognized during surgery, and 18 (17.1%) were diagnosed only after suboperative histological examination. Errors during operations in the initial PFTC forms (without careful study of macrodrugs and suboperative morphological examination) can reach 23.8%. Problems with the primary lession interpretation, which arose in 11 (10.5%) patients with a pronounced tumor process, did not prevent the choice of adequate surgery. The tumor dissemination of the fallopian tube outside was detected in 69 (72.4%) patients, in 25 (26.2%) among them there were lymph node metastases.
Conclusion. Careful revision of the abdominal organs and macroscopic examination of removed drugs using suboperative morphological studies avoids errors in the diagnosis and surgical treatment of patients with PFTC.
- Lau, H.Y., Chen, Y.J., Yen, M.S., et al. “Primary fallopian tube carcinoma: a clinicopathologic analysis and literature review.” Journal of the Chinese Medical Association 76.10 (2013): 583–7. DOI: 10.1016/j.jcma.2013.06.010
- Jeung, I.C., Lee, Y.S., Lee, H.N., Park, E.K. “Primary carcinoma of the fallopian tube: report of two cases with literature review.” Cancer research and treatment 41.2 (2009): 113–6. DOI: 10.4143/crt.2009.41.2.113
- Hyriavenko, N., Lyndin, M., Sikora, K., et al. “Serous Adenocarcinoma of Fallopian Tubes: Histological and Immunohistochemical Aspects.” Journal of pathology and translational medicine 53.4 (2019): 236–43. DOI: 10.4132/jptm.2019.03.21
- Shin, W., Won, Y.J., Yoo, C.W., et al. “Incidence trends for epithelial peritoneal, ovarian, and fallopian tube cancer during 1999-2016: a retrospective study based on the Korean National Cancer Incidence Database.” Journal of gynecologic oncology 31.4 (2020): e56. DOI: 10.3802/jgo.2020.31.e56
- Liao, C.I., Chow, S., Chen, L.M., et al. “Trends in the incidence of serous fallopian tube, ovarian, and peritoneal cancer in the US.” Gynecologic oncology 149.2 (2018): 318–23. DOI: 10.1016/j.ygyno.2018.01.030
- Sun, M., Bao, L., Shen, H., et al. “Unexpected primary fallopian tube carcinoma during gynecological operations: Clinicopathological and prognostic factors analyses of 67 cases.” Taiwanese journal of obstetrics and gynecology 58.5 (2019): 626–32. DOI: 10.1016/j.tjog.2019.07.008
- Mladenović-Segedi, L. “Primary fallopian tube carcinoma.” Medicinski pregled 62.1-2 (2009): 31–6. DOI: 10.2298/mpns0902031m
- Gayam, S., Babu, C., et al. “Case report of primary serous adenocarcinoma of fallopian tube- a diagnostic dilemma.” Obsgyne Review: Journal of Obstetric and Gynecology 4.4 (2018): 73–6. DOI: 10.17511/jobg.2018.i4.01.
- Duraisamy, K., Balasubramaniam, D., Ravi, K., Balasubramanium, A. “Laparoscopic management of early stage primary fallopian tube carcinoma.” Indian Journal of Case Reports 5.2 (2019): 148–50. DOI: 10.32677/IJCR.2019.v05.i02.01810
- Romaniuk, A., Gyryavenko, N., Lyndin, M., et al. “A rare case of tuberculous salpingitis.” Interventional medicine and applied science 8.3 (2016): 131–4. DOI: 10.1556/1646.8.2016.3.2
- Purbadi, S., Santawi, V.P., Tjahjadi, H., et al. “Case report: Unpredictable nature of tubal cancer.” Annals of Medicine and Surgery 51 (2020): 44–7. DOI: 10.1016/j.amsu.2020.01.002
- Nechushkina, V., Morchov, K., Kusnetsov, V. “Evolution of treatment for uterine corpus cancer.” Cancerous tumours 4.1 (2016): 92–8.
- Koplay, M., Dogan, N.U., Erdogan, H., et al. “Diagnostic efficacy of diffusion-weighted MRI for pre-operative assessment of myometrial and cervical invasion and pelvic lymph node metastasis in endometrial carcinoma.” Journal of medical imaging and radiation oncology 58.5 (2014): 538–46. DOI: 10.1111/1754-9485.12209
- Zhou, M., Lu, B., Lv, G., et al. “Differential diagnosis between metastatic and non-metastatic lymph nodes using DW-MRI: a meta-analysis of diagnostic accuracy studies.” Journal of cancer research and clinical oncology 141.6 (2015): 1119–30. DOI: 10.1007/s00432-014-1895-9
- Oguchi, Н., Kishigami, Y., Miyazaki, N., et al. “Fallopian Tube Cancer Diagnosed by Laparoscopy: Case Report.” Japanese journal of gynecologic and obstetric endoscopy 29.1 (2013): 177–83. DOI: 10.5180/jsgoe.29.177
- Takano, M., Kagawa, Y., Murata, S., et al. “Fallopian tube cancer incidentally diagnosed during laparoscopy for metastatic adenocarcinoma of unknown primary lesion.” Gynecology and Minimally Invasive Therapy 5.4 (2016): 166–9. DOI: 10.1016/j.gmit.2015.06.007
- Toyoda, T., Suzuki, H., Nakajima, T., et al. “Successful diagnosis of an occult fallopian tube carcinoma detected from the diaphragm metastasis.” General thoracic and cardiovascular surgery 66.8 (2018): 484–7. DOI: 10.1007/s11748-017-0881-y
- Healy, N.A., Hynes, S.O., Bruzzi, J., et al. “Asymptomatic primary fallopian tube cancer: an unusual cause of axillary lymphadenopathy.” Case reports in obstetrics and gynecology 2011 (2011): 402127. DOI: 10.1155/2011/402127
- Chen, Y., Ling, C., Bian, C.“Port-site metastasis as a primary complication following diagnostic laparoscopy of fallopian tube carcinoma: A case report.” Medicine 97.26 (2018): e11166. DOI: 10.1097/MD.0000000000011166
- Takeda, A., Manabe, S., Mitsui, T., Nakamura, Н. “Laparoscopic management of fallopian tube carcinoma with paraneoplastic cerebellar degeneration.” Gynecological Surgery 4 (2007): 131–4. DOI: 10.1007/s10397-006-0228-7
- Plante, M., Touhami, O., Trinh, X.B., et al. “Sentinel node mapping with indocyanine green and endoscopic near-infrared fluorescence imaging in endometrial cancer. A pilot study and review of the literature.” Gynecologic oncology 137.3 (2015): 443–7. DOI: 10.1016/j.ygyno.2015.03.004
- Kar, A., Kar, T., Dha, I., Panda, S. “Squash cytodiagnosis of synchronous papillary serous carcinoma of ovary and endometrium with demonstration of serous tubal intraepithelial carcinoma as a precursor lesion.” Indian journal of pathology and microbiology 60.1 (2017): 125–7. DOI: 10.4103/0377-4929.200039
- Sumtsov, G.A., Hyriavenko, N.I., Starkiv, M.P., et al. “Primary fallopian tubes cancer: incidence, problems of diagnosis and treatment.” Azerbaijan Medical Journal 3 (2019): 123–9.
- Romaniuk, A., Gyryavenko, N., Lyndin, M., et al. “Primary cancer of the fallopian tubes: histological and immunohistochemical features.” Folia medica Cracoviensia 56.4 (2016): 71–80.
- Sumtsov, D.G., Hyriavenko, N.I., Sikora, V.V., et al.“Ways of spread and metastasis of primary fallopian tube cancer: retrospective analysis from 1967 to 2019.” Azerbaijan Medical Journal 3 (2020): 70–8. DOI: 10.34921/amj.2020.3.009
- Eken, M., Temizkan, O., Kaygusuz, E.I., et al. “Primary carcinoma of the fallopian tubes: Analysis of sixteen patients.” Turkish journal of obstetrics and gynecology 12.2 (2015): 83–8. DOI: 10.4274/tjod.67355
- Zivanovic, O., Sonoda, Y., Diaz, J.P., et al. “The rate of port-site metastases after 2251 laparoscopic procedures in women with underlying malignant disease.” Gynecologic oncology 111.3 (2008): 431–7. DOI: 10.1016/j.ygyno.2008.08.024
- Timmins, P., Kanbour, A., Price, F. “Predictors for survival in fallopian tube carcinoma.” Medicine Online. Available from: [http://www.priory.com/med/fallopian.htm].
- Koo, Y.J., Kwon, Y.S., Lim, K.T., et al. “Para-aortic lymphadenectomy for primary fallopian tube cancer.” International journal of gynaecology and obstetrics 112.1 (2011): 18–20. DOI: 10.1016/j.ijgo.2010.07.025
- Nofech-Mozes, S., Khalifa, M.A., Ismiil, N., et al. “Immunophenotyping of serous carcinoma of the female genital tract.” Modern pathology 21.9 (2008): 1147–55. DOI: 10.1038/modpathol.2008.108
- Gargin, V., Radutny, R., Titova, G., et al. Application of the computer vision system for evaluation of pathomorphological images. 2020 IEEE 40th ICEN, ELNANO (2020). Proceedings, art. № 9088898:469-73. DOI: 10.1109/ELNANO50318.2020.9088898
How to Cite
Copyright (c) 2021 Д.Г. Сумцов, І.З. Гладчук, Г.О. Сумцов, Н.І. Гирявенко, М.С. Линдін, В.В. Сікора, В.М. Запорожан
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.