Efficiency of correction of vitamin D deficiency with DeviSol Strong at the preconception stage and during pregnancy

Authors

DOI:

https://doi.org/10.18370/2309-4117.2021.59.35-38

Keywords:

vitamin D deficiency, preconception, pregnancy, DaviSol Strong

Abstract

Research objective: to assess the course and consequences of pregnancy in women with vitamin D lack and deficit that is adjusted with DeviSol Strong at the pre-pregnancy preparation or during pregnancy.
Materials and methods. The study involved 145 women aged 18 to 30 years. Experimental cohort (120 women with vitamin D deficiency) was divided into three groups: the first group – 40 pregnant women, the second group – 50 patients at the stage of pre-pregnancy preparation, comparison group – 30 pregnant women at 6–10 weeks of gestation. Control group consisted of 25 pregnant women with sufficient levels of vitamin D. 25(OH)D value in serum was determined by immunochemical method with chemiluminescent detection. DeviSol Strong dietary supplement was chosen to correct vitamin D deficiency. It was administered differently, based on 25(OH)D level.
Results. Patients receiving 800 IU/day of cholecalciferol showed an increase in the vitamin D deficiency (from 46.7% to 76.7%). Vitamin D deficiency was reduced from 75.0% to 32.5% in women who received 2000 IU and 4000 IU of cholecalciferol for 3 months, the proportion of pregnant women with severe vitamin D deficiency decreased by 2,4 times. A rapid positive effect was achieved in 82.0% of pre-pregnancy patients receiving DeviSol Strong 4000 IU/day or 6000 IU/day (4000 IU + 2000 IU).
Abortion risk before 12 weeks of gestation occurred in 23.3% of women in the comparison group, in 7.5% of pregnant women in group 1, in 4.0% in control group and in 2.0% in group 2. Early miscarriage occurred in 3,3% of patients in the comparison group. 13.3% of pregnant women in the comparison group, 5.0% from group 1 and 2.0% from group 2 were hospitalized with the threat of premature birth, premature birth occurred in one patient of the comparison group.
Conclusions. Assessment of the first half of pregnancy with differentiated correction of vitamin D deficiency indicates the need for supplementation of cholecalciferol at the stage of pre-pregnancy preparation for prevention of gestation complications. DeviSol Strong is an effective drug for correcting vitamin D deficiency. Most effective dose in severe vitamin D deficiency is 6000 IU (4000 IU + 2000 IU), 4000 IU in lack and deficiency, which allowed achieving an adequate 25(OH)D level after 3 months in 82% of patients.

Author Biographies

S.O. Shurpyak, Danylo Halytsky Lviv National Medical University, Lviv

MD, professor at the Obstetrics, Gynaecology and Perinatology Department, Faculty of Postgraduate Education

V.I. Pyrohova, Danylo Halytsky Lviv National Medical University, Lviv

MD, head of the Obstetrics, Gynaecology and Perinatology Department, Faculty of Postgraduate Education

M.I. Malachinska, Danylo Halytsky Lviv National Medical University, Lviv

PhD, associate professor, Obstetrics, Gynaecology and Perinatology Department, Faculty of Postgraduate Education

References

  1. El-Hajj Fuleihan, G. “Vitamin D deficiency in the Middle East and its health consequences.” Clin Rev Bone Miner Metab 7 (2009): 77–93.
  2. Bendik, I., Friedel, A., Roos, F.F., et al. “Vitamin D: a critical and essential micronutrient for human health.” Front Physiol 5 (2014): 248.
  3. Palacios, C., Gonzalez, L. “Is vitamin D deficiency a major global public health problem?” J Steroid Biochem Mol Biol 144 (Pt A) (2014): 138–45.
  4. Manson, J.E., Brannon, P.M., Rosen, C.J., Taylor, C.L. “Vitamin D deficiency – is there realy a pandemic?” N Engl J Med 375.19 (2016): 1817–20. DOI: 10.1056/NEJMp1608005
  5. Povorozniuk, V.V., Balatska, N.I., Muts, V.Y., Vdovina, O.A. “Deficiency and insufficiency of vitamin D among residents Ukraine.” Pain. Joints. The spine Journal 4.04 (2011).
  6. Sinenkyi, O.V. “Influence of vitamin D deficiency on the course of rheumatoid arthritis and ways of its correction.” Lviv Clinical Bulletin 4.20 (2017): 15–24. DOI: 10.25040/lkv2017.04.015
  7. Holick, M.F. “The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention.” Rev Endocr Metab Disord 18.2 (2017): 153–65. DOI: 10.1007/s11154-017-9424-1
  8. Tatarchuk, T.F., Bulavenko, O.V., Kapshuk, I.M., Tarnopolska, V.O. “Vitamin D deficiency in the genesis of reproductive health disorders.” Ukr med magazine 5.109 (2015): 56–61.
  9. Harvey, N.C., Holroyd, C., Ntani, G., et al. “Vitamin D supplementation in pregnancy: a systematic review.” Health Technol Assess 18.45 (2014): 1–90. DOI: 10.3310/hta18450
  10. Perez-Lopez, F.R. “Vitamin D: the secosteroid hormone and human reproduction.” Gynecol Endocrinol 23.1 (2007): 13–24.
  11. Pyrohova, V.I., Shurpyak, S.O., Zhemela, N.O., Golota, L.I. “On the issue of prevention of complications during pregnancy failure and deficiency of vitamin D.” Womens health 6.112 (2016): 19–27.
  12. Ding, C., et al. “Vitamin D signalling in adipose tissue.” British J Nutrition 108.11 (2012): 1915–23.
  13. Vranken, L., Emonts, P., Bruyère, O., Cavalier, E. “Vitamin D deficiency during pregnancy: what's the local situation?” Rev Med Liege 73.1 (2018): 10–6.
  14. Mitchell, С. “Vitamin D supplementation for women before and during pregnancy: an update of the guidelines, evidence, and role of GPs and practice nurses.” Br J Gen Pract 67.662 (2017): 423–4. DOI: 10.3399/bjgp17X692489
  15. Wei, S.Q., Qi, H.P., Luo, Z.C., Fraser, W.D. “Maternal vitamin D status and adverse pregnancy outcomes: A systematic review and meta-analysis.” J Matern Fetal Neonatal Med 26 (2013): 889–99. DOI: 10.3109/14767058.2013.765849
  16. Cannell, J.J., Grant, W.B., Holick, M.F. “Vitamin D and inflammation.” Dermatoendocrinol 6.1 (2015): e983401-1-10. DOI: 10.4161/19381980.2014.983401
  17. Bodnar, L.M., Platt, R.W., Simhan, H.N. “Early-pregnancy vitamin D deficiency and risk of preterm birth subtypes.” Obstet Gynecol 125.2 (2015): 439–47. DOI: 10.1097/AOG.0000000000000621
  18. Pereira-Santos, M., et al. “Obesity and vitamin D deficiency: a systematic review and meta-analysis.” Obesity Reviews 16.4 (2015): 341–9.
  19. Mirzakhani, H., et al. “Early pregnancy vitamin D status and risk of preeclampsia.” J clinical investigation 126.12 (2016): 4702–15. DOI: 10.1172/JCI89031
  20. Baker, A.M., Haeri, S., Camargo, C.A. Jr, et al. “A nested case-control study of first-trimester maternal vitamin D status and risk for spontaneous preterm birth.” Am J Perinatol 28.9 (2011): 667–72. DOI: 10.1055/s-0031-1276731
  21. Bodnar, L.M., Krohn, M.A., Simhan, H.N. “Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy.” J Nutr 139.6 (2009): 1157–61.
  22. Dawodu, A., Saadi, H.F., Bekdache, G., et al. “Randomized controlled trial (RCT) of vitamin D supplementation in pregnancy in a population with endemic vitamin D deficiency.” J Clin Endocrinol Metab 98.6 (2013): 2337–46.
  23. Zhou, S.S., Tao, Y.H., Huang, K., et al. “Vitamin D and risk of preterm delivery: up-to-date meta-analysis of randomized controlled trials and observational studies.” J Obstet Gynaecol Res 43.2 (2017): 247–56. DOI: 10.1111/jog.13239
  24. Baczyńska-Strzecha, M., Kalinka, J. “Assessment of correlation between vitamin D level and prevalence of preterm births in the population of pregnant women in Poland.” Int J Occup Med Environ Health 30.6 (2017): 1–9. DOI: 10.13075/ijomeh.1896.01146
  25. Thorp, J.M., Camargo, C.A., McGee, P.L., et al. “Vitamin D status and recurrent preterm birth: a nested case-control study in high-risk women.” BJOG 119.13 (2012): 16171623. DOI: 10.1111/j.1471-0528.2012.03495.x
  26. Thorne-Lyman, A., Fawzi, W.W. “Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis.” Paediatr Perinat Epidemiol 26 Suppl 1 (2012): 75–90. DOI: 10.1111/j.1365-3016.2012.01283.x
  27. Wagner, C.L., McNeil, R., Hamilton, S.A., et al. “A randomized trial of vitamin D supplementation in 2 community health center networks in South Carolina.” Am J Obstet Gynecol 208.2 (2013): 137.e1–13.
  28. Litonjua, A.A., Carey, V.J., Laranjo, N., et al. “Effect of prenatal supplementation with vitamin D on asthma or recurrent wheezing in offspring by age 3 years: the VDAART randomized clinical trial.” JAMA 315.4 (2016): 362–70. DOI: 10.1001/jama.2015.18589

Downloads

Published

2021-07-22

How to Cite

Shurpyak, S., Pyrohova, V., & Malachinska, M. (2021). Efficiency of correction of vitamin D deficiency with DeviSol Strong at the preconception stage and during pregnancy. REPRODUCTIVE ENDOCRINOLOGY, (59), 35–38. https://doi.org/10.18370/2309-4117.2021.59.35-38

Issue

No. 59 (2021)

Section

Pregnancy and childbirth

License

Copyright (c) 2021 С.О. Шурпяк, В.І. Пирогова, М.Й. Малачинська

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.