Experience of using plant complexes in physiological completion of lactation





lactation, mammary gland involution, prolactin, Normomens


Ending breastfeeding is often quite a challenge for women, justifying the need for qualified medical counseling and accompaniment by a doctor. Quite frequently during weaning the baby, women complain about pain, discomfort and swelling of the breasts, which affects their overall physical and psychological well-being. However, due to possible rather serious side effects, medical support for stopping lactation is mostly recommended for women with clinical indications.
Research aim: to determine the effectiveness of the proposed method with Normomens for physiological completion of lactation.
Materials and methods. The study involved 65 women with an average duration of lactation 9 ± 1.23 months. Patients were divided into two groups: group 1 included 34 women who received Normomens according to the scheme to stop lactation; group 2 included 31 patients who did not receive any medication. Patients were gynecological examined and counseled by oncologist. Patients' diaries included questions about the duration of lactation, presence and severity of mastalgia according to the Visual Analogue Scale, necessity of analgesics, frequency of breast pumping per day, features of psycho-emotional state according to the Hospital Anxiety and Depression Scale. Prolactin levels were also determined at the screening visit and on 25th day after weaning.
Results. On the background of Normomens use the process of lactation completion was significantly easier, its completion came mostly on the 3–4 day after drug use, patients almost never complained of pain and discomfort in mammary glands, they less frequently breast pumped and had a more stable psycho-emotional state compared to the control group. Рrolactin level with usage of Normomens had a quick decrease compared to the control group.
Conclusion. Normomens using for support the physiological finishing of lactation lead to acceleration of involutive processes in mammary glands, reduces pain severity and prevented psycho-emotional disorders in women.

Author Biographies

N. V. Kosei, SI “O.M. Lukyanova IPOG of the NAMS of Ukraine”; SSI “CIMT of the NAS of Ukraine"

MD, professor, chief researcher, Endocrine Gynecology Department;

Head of Department of Reproductive Health

O.V. Zanko, SSI “ CIMT of the NAS of Ukraine”

PhD, researcher, Department of Reproductive Health

L.А. Vasylchenko, SSI “CIMT of the NAS of Ukraine”

PhD, senior researcher, Department of Reproductive Health

N.V. Iarotska, SI “O.M. Lukyanova IPOG of the NAMS of Ukraine”

Junior researcher, Endocrine Gynecology Department


  1. Alekseev, N.P. Physiology of lactation of women: monograph. Moscow. Yurayt (2019): 300 p.
  2. Antypkin, Y.G., Kaminskyi, V.V., Tatarchuk, T.F. “Optimization of family planning service in Ukraine in the realization of modern strategy of woman health maintenance.” Reproductive Endocrinology 3.35 (2017): 7–16. OI: 10.18370/2309-4117.2017.35.7-16
  3. Golyanovskiy, O.V., Kovalchuk, E.V. “Modern aspects of suppression of lactation in the post-abortion and postpartum periods.” Women's health 4 (2013): 56–8.
  4. Tatarchuk, T.F., Gunkov, S.V., Efimenko, O.O. “The current development before diagnosis and treatment of hyperprolactinemia.” Reproductive endocrinology 3 (2012): 26–44. DOI: 10.18370/2309-4117.2012.3.26-44
  5. Tronko, M.D., Antipkin, Y.G., Kaminskyi, V.V., Tatarchuk, T.F. “National consensus on the management of patients with hyperprolactinemia.” Reproductive endocrinology 30 (2016): 8–18. DOI: 10.18370/2309-4117.2016.30.8-18
  6. Yankovskiy, D., et al. “Microbial ecology of newborns: features of the formation of the microbiome and prevention of its violations.” Neonatology, surgery and perinatal medicine 2.16 (2015): 93–105.
  7. Ajmera, V.H., et al. “Longer lactation duration is associated with decreased prevalence of non- alcoholic fatty liver disease in women.” Journal of Hepatology 70.1 (2019): 126–32. DOI: 10.1016/j.jhep.2018.09.013
  8. Akbar, N.H., Rizki, M.I. “Potential Analgesic Agents and Action Mechanism of Phytochemicals from Indonesia Natural Products – A Review.” International Conference on NAMES 2015, Banjarbaru, Kalimantan Selatan, 14 January 2015.
  9. Al Ameri, K.R.J. “Cabergoline (Dostinex) Effect on Weight Ovarian Function.” Family Medicine & Medical Science Research 06.02 (2017). DOI: 10.4172/2327-4972.1000217
  10. Amro, B.I., Abu Hajleh, M.N., Afifi, F. “Evidence-Based Potential of some Edible, Medicinal and Aromatic Plants as Safe Cosmetics and Cosmeceuticals.” Tropical Journal of Natural Product Research 5.1 (2021): 16–48. DOI: 10.26538/tjnpr/v5i1.3
  11. Boutinaud, M., et al. “Inhibiting prolactin by cabergoline accelerates mammary gland remodeling during the early dry period in dairy cows.” Journal of Dairy Science 100.12 (2017): 9787–98. DOI: 10.3168/jds.2017-12783
  12. Cerqueira, R., et al. “Vitex agnus castus for premenstrual syndrome and premenstrual dysphoric disorder: a systematic review.” Archives of Women's Mental Health 20.6 (2017): 713–19. DOI: 10.1007/s00737-017-0791-0
  13. Czosnykowska-Łukacka, M., Królak-Olejnik, B., Orczyk-Pawiłowicz, M. “Breast Milk Macronutrient Components in Prolonged Lactation.” Nutrients 10.12 (2018): 1893. DOI: 10.3390/nu10121893
  14. Del Ciampo, L., Del Ciampo, L. “Breastfeeding and the Benefits of Lactation for Women's Health.” RBGO Gynecology and Obstetrics 40.06 (2018): 354–9. DOI: 10.1055/s-0038-1657766
  15. Farzaei, M.H., Niroumand, M.C., Heydarpour, F. “Pharmacological and therapeutic effects of Vitex agnus-castus L.: A review.” Pharmacognosy Reviews 12.23 (2018): 103. DOI: 10.4103/phrev.phrev_22_17
  16. Heskes, A.M., et al. “Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus castus.” The Plant Journal 93.5 (2018): 943–58. DOI: 10.1111/tpj.13822
  17. Immke, D.C., Gavva, N.R. “The TRPV1 receptor and nociception.” Seminars in Cell & Developmental Biology 17.5 (2006): 582–591. DOI: 10.1016/j.semcdb.2006.09.004
  18. Harris, К., et al. “Safety of Cabergoline for Postpartum Lactation Inhibition or Suppression: A Systematic Review.” Journal of Obstetrics and Gynaecology Canada 42.3 (2020): 308–15. DOI: 10.1016/j.jogc.2019.03.014
  19. Kabiri, M., et al. “Management of Breast Milk Oversupply in Traditional Persian Medicine.” Journal of Evidence-Based Complementary & Alternative Medicine 22.4 (2017): 1044–50. DOI: 10.1177/2156587217722474
  20. Kelly, A.-M. “The minimum clinically significant difference in visual analogue scale pain score does not differ with severity of pain.” Emergency Medicine Journal 18.3 (2001): 205–7. DOI: 10.1136/emj.18.3.205
  21. Koletzko, B., et al. “Nutrition During Pregnancy, Lactation and Early Childhood and its Implications for Maternal and Long-Term Child Health: The Early Nutrition Project Recommendations.” Annals of Nutrition and Metabolism 74.2 (2019): 93–106. DOI: 10.1159/000496471
  22. Oladapo, O., Fawole, B. “Treatments for suppression of lactation.” Cochrane Database of Systematic Reviews (2006). DOI: 10.1002/14651858.cd005937
  23. Sari, D.N., Mulyani, Y. “Zingiber Officinale and Pure Honey in Overcoming The Invisibility Of Back Pain in Trimester III Pregnant Women.” STRADA Jurnal Ilmiah Kesehatan 9.2 (2020): 1403–8. DOI: 10.30994/sjik.v9i2.481
  24. Sriraman, N.K. “The Nuts and Bolts of Breastfeeding: Anatomy and Physiology of Lactation.” Current Problems in Pediatric and Adolescent Health Care 47.12 (2017): 305–10. DOI: 10.1016/j.cppeds.2017.10.001
  25. Stern, A.F. “The Hospital Anxiety and Depression Scale.” Occupational Medicine 64.5 (2014): 393–4. DOI: 10.1093/occmed/kqu024
  26. van Veldhuizen-Staas, C.G.A. “Overabundant milk supply: an alternative way to intervene by full drainage and block feeding.” International Breastfeeding Journal 2.1 (2007): 11. DOI: 10.1186/1746-4358-2-11
  27. Verkaik, S., Kamperman, A.M., van Westrhenen, R., Schulte, P.F.J. “The treatment of premenstrual syndrome with preparations of Vitex agnus castus: a systematic review and meta-analysis.” American Journal of Obstetrics and Gynecology 217.2 (2017): 150–66. DOI: 10.1016/j.ajog.2017.02.028
  28. World Health Organization. WHO Guideline: counselling of women to improve breastfeeding practices. Geneva. WHO (2018): 99 p.
  29. Yang, Y., et al. “Is Cabergoline Safe and Effective for Postpartum Lactation Inhibition? A Systematic Review.” International Journal of Women's Health 12 (2020): 159–70. DOI: 10.2147/ijwh.s232693



How to Cite

Kosei, N. V. ., Zanko, O. ., Vasylchenko, L. ., & Iarotska, N. . (2021). Experience of using plant complexes in physiological completion of lactation. REPRODUCTIVE ENDOCRINOLOGY, (57), 54–58. https://doi.org/10.18370/2309-4117.2021.57.54-58



Physiology and pathology of the mammary glands