Magnesium in the prevention of gestational complications in women with pregnancy induced in the art cycle
Keywords:magnesium, pregnancy, assisted reproductive technologies, magnesium deficiency, obstetric complications, drug correction, Metida
This article provides data on the role of magnesium in ensuring the vital activity of the human body, its role in reproduction and the development of obstetric complications. The methods of diagnostics and medications for the correction of magnesium deficiency are considered.
Purpose of the study was to examine the effectiveness of complex water-soluble agent containing magnesium citrate and vitamin B6 in the complications prevention of pregnancy induced in cycles of assisted reproductive technologies (ART).
Materials and methods. 215 women with pregnancy induced in ART cycles were randomized into two groups: the main group received a prophylactic complex water-soluble drug Metida containing magnesium citrate 1970 mg (elemental magnesium 300 mg) and vitamin B6 30 mg from 1 to 36 weeks of pregnancy, 1 time per day. The comparison group (105 women) did not receive magnesium. The control group consisted of 53 relatively healthy women with pregnancy after natural conception.
Serum and erythrocyte magnesium levels were studied at 6–8, 18–20 and 30–32 weeks of gestation. Clinical course of pregnancy and childbirth were evaluated. Magnesium deficiency should be determined by the content of magnesium in erythrocytes, as its level in serum is still normal, i.e. within the reference interval.
Results. Metida in women with induced pregnancy in ART cycles compared to the group in which magnesium drugs were not prescribed reduced the number of preterm birth in 2.62 times, placental dysfunction in 2.24 times, gestational diabetes mellitus in 2.62 times, premature birth in 2.28 times and increased the number of timely births in 1.12 times.
Conclusion. Use of the magnesium-containing drug Metida from the earliest stages of pregnancy has optimized the course and outcome of pregnancy and reduced the number of miscarriage and complications, as well as increased the number of timely births. Safety and bioavailability of magnesium are important properties of Metida. This drug has maximum compliance – high efficiency and digestibility.
Arzhanova, O.N., Paikacheva, Y.M., Kapustin, R.V., et al. “Causes of obstetric complications in patients after assisted reproductive technologies.” Journal of Obstetrics and Women's Diseases 66.3 (2017): 25–33. DOI: 10.17816/JOWD66325-33
Beketova GV, Gnatenko TN. Magnesium and Children's Health: What's New? Pediatrics. Eastern Europe. 2016; 4 (4): 604–20.
Burchinsky, S.G. “The problem of magnesium deficiency in the body: methods of pharmacological correction.” Health-ua.com (specialty medical portal) (2015). Available from: [https://health-ua.com/article/18362-problema-defitcita-magniya-v-organizme-metody- farmakologicheskoj-korrektcii].
Dadak, K. “Magnesium deficiency in obstetrics and gynecology.” Obstetrics, gynecology, reproduction 7.2 (2013): 6–14.
Dikke, G.B. “Myths and facts of the magnesium use in obstetric practice.” Obstetrics, gynecology, reproduction 11.3 (2017): 59–68. DOI: 10.17749/2313-7347.2017.11.3.059-068
Dikke, G.B. “The role of magnesium in physiological pregnancy. Contraversion and proof.” Meditsinskiy sovet 19 (2016): 96–102.
Marushko, Y.V., Gishchak, T.V. “Rationale for the use of magnesium supplements in pediatric practice (literature review).” Modern pediatrics 6.78 (2016): 27–32. DOI: 10.15574/SP.2016.78.27
Resolution III of the International Expert Council on Magnesium Deficiency in Obstetrics and Gynecology. Obstetrics and Gynecology 12 (2015): 153.
Serov, V.N., Blinov, D.V., Zimovina, U.V., Dzhobava, E.M. “Results of a study on the prevalence of magnesium deficiency in pregnant women.” Obstetrics and Gynecology 6 (2014): 33–40
Shelayeva, E.V., Musina, E.V., Yarmolinskaya, M.I., et al. “Features of high-risk pregnancy management after in vitro fertilization (description and discussion of clinical observation).” Journal of Obstetrics and Women's Diseases 67/6 (2018): 112–8. DOI: 10.178/JOWD676112-118
Shurpyak, S.O. “Somatic and obstetric aspects of magnesium deficiency (Clinical lecture).” Women's health 8.114 (2016): 10–7.
Al Alawi, A.M., Majoni, S.W., Falhammar, H. “Magnesium and Human Health: Perspectives and Research Directions.” Int J Endocrinol 2018 (2018): 9041694. DOI: 10.1155/2018/9041694
Antwi-Boasiako, C., Kusi-Mensah, Y.A., Hayfron-Benjamin, C., et al. “Total Serum Magnesium Levels and Calcium-To-Magnesium Ratio in Sickle Cell Disease.” Medicina (Kaunas) 55.9 (2019): 547. DOI: 10.3390/medicina55090547
Asemi, Z., Karamali, M., Jamilian, M., et al. “Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: a randomized, double- blind, placebo-controlled trial.” The American Journal of Clinical Nutrition 102.1 (2015): 222–9. DOI: 10.3945/ajcn.114.098616
Bertinato, J., Wu Xiao, C., Ratnayake, W.M., et al. “Lower serum magnesium concentration is associated with diabetes, insulin resistance, and obesity in South Asian and white Canadian women but not men.” Food & Nutrition Research 59.1 (2015): 25974. DOI: 10.3402/fnr.v59.25974
de Baaij, J.H.F., Hoenderop, J.G.J., Bindels, R.J.M. “Magnesium in man: implications for health and disease.” Physiological Reviews 95.1 (2015): 1–46. DOI: 10.1152/physrev.00012.2014
Duley, L., Gülmezoglu, A.M., Chou, D. “Magnesium sulphate versus lytic cocktail for eclampsia.” Cochrane Database Syst Rev 9 (2010): CD002960. DOI: 10.1002/14651858. CD002960.pub2
Ekim, M., Ekim, H., Yilmaz, Y.K., et al. “Study on relationships among deep vein thrombosis, homocysteine & related B group vitamins.” Pak J Med Sci 31.2 (2015): 398–402. DOI: 10.12669/pjms.312.6049
Galan, P., Preziosi, P., Durlach, V., et al. “Dietary magnesium intake in a French adult population.” Magnes Res 10.4 (1997): 321–8.
Grober, U., Schmidt, J., Kisters, K. “Magnesium in prevention and therapy.” Nutrients 7.9 (2015): 8199–226. DOI: 10.3390/nu7095388
Hron, G., Lombardi, R., Eichinger, S., et al. “Low vitamin B6 levels and the risk of recurrent venous thromboembolism.” Haematologica 92.9 (2007): 1250–3. DOI: 10.3324/haematol.11318
Jahnen-Dechent, W., Ketteler, M. “Magnesium basics.” Clinical Kidney Journal 5 Suppl. 1 (2012): i3–i14. DOI: 10.1093/ndtplus/sfr163
Jamilian, M., Samimi, M., Faraneh, A.E., et al. “Magnesium supplementation affects gene expression related to insulin and lipid in patients with gestational diabetes.” Magnes Res 30.3 (2017): 71–9. DOI: 10.1684/mrh.2017.0425
Jin, S., Sha, L., Dong, J., et al. “Effects of Nutritional Strategies on Glucose Homeostasis in Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis.” Diabetes Res 2020 (2020): 6062478. DOI: 10.1155/2020/6062478
Khan, A.A., Koch, C.A., Van Uum, S., et al. “Standards of care for hypoparathyroidism in adults: a Canadian and International Consensus.” Eur J Endocrinol 180.3 (2019): P1–P22. DOI: 10.1530/EJE-18-0609
Kunkel, H.O., Pearson, P.B., Schweigert, B.S. “The photoelectric determination of magnesium in body fluids.” J Lab Clin Med 32.8 (1947): 1027–33.
Makrides, M., Crowther, C.A. “Magnesium supplementation in pregnancy.” Cochrane Database Syst Rev 4 (2001): CD000937. DOI: 10.1002/14651858.CD000937. Update in: Cochrane Database Syst Rev 4 (2014): CD000937.
Martin, K.J., Gonzalez, E.A., Slatopolsky, E. “Clinical consequences and management of hypomagnesemia.” Journal of American Society of Nephrology 20.11 (2009): 2291–5. DOI: 10.1681/ASN.2007111194
Medication Errors in Labor and Delivery: Reducing Maternal and Fetal Harm. Pennsylvania Patient Safety Advisory 6 Suppl. 1 (2009): 1–6. Available from: [http://patientsafety.pa.gov/ADVISORIES/documents/2009sup1_01.pdf], last accessed Nov 14, 2020.
Morais, J.B.S., Severo, J.S., de Alencar, G.R.R., et al. “Effect of magnesium supplementation on insulin resistance in humans: a systematic review.” Nutrition 38 (2017): 54–60. DOI: 10.1016/j.nut.2017.01.009
Pilchova, I., Klacanova, K., Tatarkova, Z., et al. “The involvement of Mg2+ in regulation of cellular and mitochondrial functions.” Oxidative Medicine and Cellular Longevity 2017 (2017): 8. DOI: 10.1155/2017/6797460.6797460
Prokopovich, O.A., Kalacheva, A.G., Torshin, I.Y., et al. “Prospects for the use of soluble organic magnesium.” Meditsinskiy sovet 11 (2015): 90–7. DOI: 10.21518/2079-701X-2015-11-90-97
Viering, D.H.H.M., de Baaij, J.H.F., Walsh, S.B., et al. “Genetic causes of hypomagnesemia, a clinical overview.” Pediatric Nephrology 32.7 (2017: 1123–35. DOI: 10.1007/s00467-016-3416-3
Williamson, M.A., Snyder, L.M., Wallach, J.B. Wallach's Interpretation of Diagnostic Tests. 9th. Philadelphia, PA, USA. Wolters Kluwer/Lippincott Williams & Wilkins (2011), XVI, 1143.
World Health Organization. Calcium and Magnesium in Drnking Water: Public health significance. Geneva. WHO Press (2009).
Young, G.L., Jewell, D. “Interventions for leg cramps in pregnancy.” Cochrane Database Syst Rev 1 (2002): CD000121. DOI: 10.1002/14651858.CD000121
Claxton, A.J., et al. “A Systematic Review of the Associations Between Dose Regimens and Medication Compliance. Clinical therapeutics 23.8 (2001): 1296–1310.
Kane, J.M., Kishimoto, T., Correll, C.U. “Non-adherence to treatment in patients with psychotic disorders: epidemiology, predisposing factors and tactics.” World Psychiatry 12 (2013): 216–26.
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