Magnesium in the prevention of gestational complications in women with pregnancy induced in the art cycle




magnesium, pregnancy, assisted reproductive technologies, magnesium deficiency, obstetric complications, drug correction, Metida


This article provides data on the role of magnesium in ensuring the vital activity of the human body, its role in reproduction and the development of obstetric complications. The methods of diagnostics and medications for the correction of magnesium deficiency are considered.

Purpose of the study was to examine the effectiveness of complex water-soluble agent containing magnesium citrate and vitamin B6 in the complications prevention of pregnancy induced in cycles of assisted reproductive technologies (ART).

Materials and methods. 215 women with pregnancy induced in ART cycles were randomized into two groups: the main group received a prophylactic complex water-soluble drug Metida containing magnesium citrate 1970 mg (elemental magnesium 300 mg) and vitamin B6 30 mg from 1 to 36 weeks of pregnancy, 1 time per day. The comparison group (105 women) did not receive magnesium. The control group consisted of 53 relatively healthy women with pregnancy after natural conception.

Serum and erythrocyte magnesium levels were studied at 6–8, 18–20 and 30–32 weeks of gestation. Clinical course of pregnancy and childbirth were evaluated. Magnesium deficiency should be determined by the content of magnesium in erythrocytes, as its level in serum is still normal, i.e. within the reference interval.

Results. Metida in women with induced pregnancy in ART cycles compared to the group in which magnesium drugs were not prescribed reduced the number of preterm birth in 2.62 times, placental dysfunction in 2.24 times, gestational diabetes mellitus in 2.62 times, premature birth in 2.28 times and increased the number of timely births in 1.12 times.

Conclusion. Use of the magnesium-containing drug Metida from the earliest stages of pregnancy has optimized the course and outcome of pregnancy and reduced the number of miscarriage and complications, as well as increased the number of timely births. Safety and bioavailability of magnesium are important properties of Metida. This drug has maximum compliance – high efficiency and digestibility.

Author Biographies

O. M. Nosenko, Odesa National Medical University

MD, professor, Obstetrics and Gynecology Department No. 1

F. O. Khancha, Donetsk National Medical University named after Maxim Gorky

PhD, assistant, Department of Obstetrics and Gynecology


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How to Cite

Nosenko, O. M., & Khancha, F. O. (2020). Magnesium in the prevention of gestational complications in women with pregnancy induced in the art cycle. REPRODUCTIVE ENDOCRINOLOGY, (56), 80–87.



Pregnancy and childbirth