Association of gene polymorphism with menorrhagia combined with thyroid pathology




teenage girls, puberty menorrhagia, thyroid gland, GP IIIa gene polymorphism, allele, genotype


Purpose of the study: to establish the frequency of alleles and genotypes of GP IIIa gene polymorphism in adolescent girls with uterine bleeding that is concomitant thyroid pathology and conduct a thorough genetic analysis of patients.

Materials and methods. 70 teenage girls with puberty menorrhagia were surveyed. Study groups: I (main) – 30 teenage girls with puberty menorrhagia against the background of thyroid gland pathology, II group (comparison) – 40 teenage girls diagnosed with puberty menorrhagia. Control group consist of 25 almost healthy teenage girls. GP IIIa gene polymorphism (PLA1/PLA2) was studied once using PCR polymerase chain reaction.

Results. A1/A2 polymorphism of the GP IIIa gene in adolescent girls with menorrhagia against the background of thyroid pathology indicates the likely prevailing frequency of individuals with “favorable” A1 allele over such with A2A2 genotype with and without pathology: in 12.3 and 9 times respectively. In adolescents without concomitant pathology A1A1 genotype was observed 11.7% more frequently than those with thyroid disease and 15.0% more often than in the control group. Distribution of genotypes of the GP IIIa gene polymorphous locus corresponded to the expected Hardy-Weinberg population balance, both in general and separately in the surveyed groups.

Conclusions. In adolescents with menorrhagia without thyroid pathology A1A1 genotype occur 11.7% more frequently than in girls with thyroid diseases and 15.0% more often than in the control group. Relative frequency of A1A2- genotype is 9.2% in girls with menorrhagia and thyroid pathology, and A2A2 genotype by 2.5% over such in adolescents of comparison groups. Thus, risk factors for uterine bleeding with existing thyroid pathology in adolescent girls may depend on gene polymorphism.

Author Biographies

O. A. Andriets, Bukovinian State Medical University

MD, professor, Department of Obstetrics and Gynecology

O. M. Yuzko, Bukovinian State Medical University

MD, professor, head of the Department of Obstetrics and Gynecology

Y. V. Tsysar, Bukovinian State Medical University

PhD, assistant, Department of Obstetrics and Gynecology


  1. Gerasimova, T.V. “Management of adolescents with hypothalamic-pituitary dysfunction.” Medical aspects of woman’s health 9–10.38–39 (2010): 5–10. DOI: 10.1837/2309-4117.2010.39.5-10
  2. Grigorova, I., Tuchkina, I., Tuchkina, M. “Neurological disorders and endocrine status of the body in the process of formation of the female reproductive system.” Medicine today and tomorrow 2–3 (2010): 174–8. DOI: 10.1837/2309-4117.2010.3.174-178
  3. Dynnik, V.O., Sulima, T.M. “Impact of perinatal period on peculiarities of clinical course of pubertic uterine bleeding.” Perinathology and Pediatrics 4 (2010): 37–9. DOI: 10.1837/2309-4117.2010.4.37-39
  4. Dynnik, V.O. Puberty uterine bleeding: clinic, pathogenesis, treatment, prognosis. Thesis abstract for MD degree, specialty 14.01.01 “Obstetrics and Gynecology”. Kyiv (2010): 40 p.
  5. Levenets, S.O., Verkhoshanova, O.G. “Perinatal history and extragenital pathology in girls with premature isolated telargue.” Perinathology and pediatrics 1 (2011): 42–3. DOI: 10.1837/2309-4117.2011.1.42-43
  6. Lytvynenko, K.O. “Disorders of reproductive function of a woman in thyroid diseases.” Pediatrics, obstetrics and gynecology 4 (2011): 234–7. DOI: 10.1837/2309-4117.2011.4.234-237
  7. Mamenko, M.E., Bielykh, N.A., Ierohina, O.I. “Perinatal aspects of iodine deficiency diseases.” Perinathology and Pediatrics 1.45 (2011): 38–41. DOI: 10.1837/2309-4117.2011.1.38-41
  8. Bulyk, L.M., Tsypkun, A.G., Davydova, Y.V, Apresova, K.G. “Preconcepcal prevention of metabolic disorders in women with diffusion non-toxic goiter.” Women’s health 5.61 (2011): 58–61. DOI: 10.1837/2309-4117.2011.1.58-61
  9. Nikitin, O.D., Gontar, Y.V., Ilyn, I.E., Zhabitskaya, L.A. “Role of cytogenetic examination of pacients with disrupted reproductive functions.” Women’s health 5.61 (2011): 162–5. DOI: 10.1837/2309-4117.2011.5.162-165
  10. Tatarchuk, T.F., Kalugina, L.V., Kolomeychuk, V.M., Rudenko, N.G. “State of reproductive health of girls and teenage girls of Ukraine.” Women’s health 7.63 (2011): 152–6. DOI: 10.1837/2309-4117.2011.7.152-156
  11. Franchuk, A.Y., Zhyliaev, M.I., Sopel, V.V. “Clinical and pathogenic aspects of endocrine infertility in women with subclinical hypothyreosis.” Topical issues of pediatrics, obstetrics and gynecology 1 (2010): 145–7. DOI: 10.1837/2309-4117.2010.1.145-147
  12. Gong, H., Shen, P., Flevaris, G., et al. “Protein subunit G–alpha–13 binds to integrin alphaIIb–beta–3 and mediates integrin 'outside–in' signaling.” Science 327 (2010): 340–3.
  13. Druckmann, R. “Dysfunctional uterine bleeding: from adolescence to menopause.” Horm Mol Clin Invest 3 (2010): 461–7.
  14. Whitaker, L., Critchley, H.O.D. "Abnormal uterine bleeding." Best practice & Research Clinical Obstetrics and Gynaecology 34 (2016): 54–65.
  15. Cihangir, E. “Coagulation and fibrinolysis in thyroid dysfunction.” Endocrine 92.7 (2010): 2415–20.
  16. Mansourian, A., Ahmadi, R., Saifi, A. “The children reference range of thyroid hormones in northern Iran.” Pakistan journ. of biol. Sciences 13.17 (2010): 862–5.
  17. Kunicki, T.J., Williams, S.A., Nugent, D.J., et al. “Mean platelet volume and integrin alleles correlate with levels of integrins α(IIb)β(3) and α(2)β(1) in acute coronary syndrome patients and normal subjects.” Arterioscler Thromb Vasc Biol 32.1 (2012): 147–52.
  18. Milne, R.L., Antoniou, A.C. “Genetic modifiers of cancer risk for BRCA1 and BRCA2 mutation carriers.” Ann Oncol 22.1 (2011): 11–17.
  19. Urbaniak, S.J., Barker, R.N. Patent 8398987 USA, International Classes A61K39/00. Use of platelet glycopeptide IIIa epitopes in the treatment of immune thrombocytopenic purpura. Assignee: The University of Aberdeen (GB) and Scottish Health Service (GB). Application Number: 12/523549; Filing Date: 01/18/2008; Publication Date: 03/19/2013. Available from: [http://www.freepatentsonline. com/8398987.html].
  20. Weger, M., Renner, W., Steinbrugger, I., et al. “Role of Thrombophilic Gene Polymorphisms in Branch Retinal Vein Occlusion.” Ophthalmology 112.11 (2012): 1910–5.
  21. Mansourian, A.R., et al. “The Children reference range of thyroid hormones in Northen Iran.” Pakistan journal of biological sciences 13.17 (2010): 862–5.
  22. Abderrazek, F., Chakroun, T., Addad, F., et al. “The GP IIIa PlA polymorphism and the platelet hyperactivity in Tunisian patients with stable coronary artery disease treated with aspirin.” Thromb Res 25.6 (2010): 265–8.
  23. Jakubowska, A., Rozkrut, D., Antoniou, A., et al. “The Leu33Pro polymorphism in the ITGB3 gene does not modify BRCA1/2–associated breast or ovarian cancer risks: results from a multicenter study among 15,542 BRCA1 and BRCA2 mutation carriers.” Breast Cancer Res Treat 121.3 (2010): 639–49.
  24. Thomas, J., Kunicki, J.T, Nugent, J.D. “The genetics of normal platelet reactivity.” Blood 116.15 (2010): 2627–34.
  25. Wong, L.P. “Premenstrual syndrome and dysmenorrhea: urban-rural and multiethnal differences in perception, impacts, and treatment seeking.” Journal of pediatric and adolescent gynecology 24.5 (2011): 272–77.



How to Cite

Andriets, O. A., Yuzko, O. M., & Tsysar, Y. V. (2020). Association of gene polymorphism with menorrhagia combined with thyroid pathology. REPRODUCTIVE ENDOCRINOLOGY, (56), 73–77.



Interdisciplinary consilium