Systematic analysis of composition and molecular mechanisms of action of the Vitex agnus-castus standardized extracts. Literature review

Authors

  • И. Ю. Торшин Russian Satellite Centre of Trace Element – Institute for UNESCO, Moscow, Russian Federation, Russian Federation
  • О. А. Громова Ivanovo State Medical Academy of the Ministry of Social Health of the Russian Federation Russian Satellite Centre of Trace Element – Institute for UNESCO, Moscow, Russian Federation, Russian Federation
  • О. А. Лиманова Ivanovo State Medical Academy of the Ministry of Social Health of the Russian Federation, Ivanovo, Russian Federation, Russian Federation

DOI:

https://doi.org/10.18370/2309-4117.2020.54.123-129

Keywords:

Vitex agnus-castus, standardized extracts, phytoestrogens, dopamine receptors modulation, hyperprolactinemia reduction

Abstract

Extracts of Vitex agnus-castus are used to regulate the menstrual cycle, in the treatment of premenstrual tension syndrome, hyperprolactinemia, and infertility. Vitex extracts component analysis showed the presence of such compounds as vitexin, rotundifuran, kastitsin, artemetin and some phytoestrogens. Extracts components are characterized with antiinflammatory, antiproliferative, antioxidant, antimicrobial (particularly antifungal), vasoprotective and analgesic effects. The role of the extracts components in modulation of opioid and dopamine receptors has been described. The paper also reviews estrogen modulating and anti-hyperprolactinemic properties of Vitex extracts

Author Biographies

И. Ю. Торшин, Russian Satellite Centre of Trace Element – Institute for UNESCO, Moscow, Russian Federation

PhD, consultant

О. А. Громова, Ivanovo State Medical Academy of the Ministry of Social Health of the Russian Federation Russian Satellite Centre of Trace Element – Institute for UNESCO, Moscow, Russian Federation

MD, professor, Department of Pharmacology with Clinical Pharmacology, head of the Course of Clinical Pharmacology

Deputy director for research work

О. А. Лиманова, Ivanovo State Medical Academy of the Ministry of Social Health of the Russian Federation, Ivanovo, Russian Federation

PhD, associate professor

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Published

2020-10-20

How to Cite

Торшин, И. Ю., Громова, О. А., & Лиманова, О. А. (2020). Systematic analysis of composition and molecular mechanisms of action of the Vitex agnus-castus standardized extracts. Literature review. REPRODUCTIVE ENDOCRINOLOGY, (54), 123–129. https://doi.org/10.18370/2309-4117.2020.54.123-129

Issue

No. 54 (2020)

Section

Gynecology

License

Copyright (c) 2020 И. Ю. Торшин, О. А. Громова, О. А. Лиманова

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