DOI: https://doi.org/10.18370/2309-4117.2020.53.19-22

Impact of an increased exposure with manganese and nickel on pituitary hormones in women with ovarian polycystosis

М. Г. Проданчук, Т. Ф. Татарчук, С. В. Гуньков, П. Г. Жмінько, С. І. Регеда

Abstract


Objective of the study: to evaluate the possible impact of manganese and nickel on the state of gonadotropic pituitary function and prolactin secretion.

Materials and methods. For the study 2 groups of women were selected. The control group consisted of 38 women of reproductive age without reproductive system pathology. The main group consisted of 52 women who were diagnosed with polycystic ovarian syndrome (PCOS) in accordance with the Rotterdam Consensus criteria. Mass spectrometry was used in both groups to determine the indicators of manganese and nickel in serum. Evaluation of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin in serum was performed by the enzyme immunoassay. To assess the statistical significance of data (p) we used the Mann-Whitney U-test and Student's t-test. Spearman's coefficient was used for correlation analysis.

Results. Studies have shown that women with PCOS compared with the control group showed increased manganese levels (p = 0.0093) and nickel levels (p = 0.00019) in serum. Prolactin (p = 0.0024) and LH levels (p = 0.0001) were increased in the group of women with PCOS too. FSH in both groups practically did not differ (p = 0.074). Significant individual fluctuations in the secretion of gonadotropins and prolactin were observed in the main group. In authors’ opinion, this may be a sign of pituitary dysfunction. Only correlation between manganese-prolactin and manganese-LH levels was found in the group of women with PCOS. There was no relationship between level of trace elements and hormones in all other cases.

Conclusion. Increased levels of manganese and nickel in serum were found in women with PCOS. Elevated prolactin and LH levels in women with PCOS may be associated with increased manganese exposure. Nickel exposure does not affect gonadotropin and prolactin levels in women with PCOS.


Keywords


manganese; nickel; polycystic ovaries; pituitary gonadotropins.

References


Oyola, M.G. “Hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes: sex differences in regulation of stress responsivity,” Handa Stress 20.5 (2017): 476–94. DOI: 10.1080/10253890.2017.1369523

Plant, T.M. “The hypothalamo-pituitary-gonadal axis.” J Endocrinol 226.2 (2015): T41–T54. DOI: 10.1530/JOE-15-0113

Rosenfield, R.L., Ehrmann, D.A. “The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism.” Revisited Endocr Rev 37.5 (2016): 467–520. DOI: 10.1210/er.2015-1104

Goodman, N.F., Cobin, R.H., Futterweit, W., et al. “American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society disease state clinical review: guide to the best practices in the evaluation and treatment of polycystic ovary syndrome - part 1.” Endocr Pract 21.11 (2015): 1291–300. DOI: 10.4158/EP15748.DSC

Witchel, S.F., Oberfield, S.E., Peña, A.S. “Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls.” J Endocr Soc 3.8 (2019): 1545–73. DOI: 10.1210/js.2019-00078

Tortonese, D.J. “Intrapituitary Mechanisms Underlying the Control of Fertility: Key Players in Seasonal Breeding.” Domest Anim Endocrinol 56 (Suppl) (2016): 191–203. DOI: 10.1016/j.domaniend.2016.01.002

Bryant, A.S., Greenwood, A.K., Juntti, S.A., et al. “Dopaminergic inhibition of gonadotropin-releasing hormone neurons in the cichlid fish Astatotilapia burtoni.” J Exp Biol 219.24 (2016): 3861–5. DOI: 10.1242/jeb.147637

Levine, S., Muneyyirci-Delale, O. “Stress-Induced Hyperprolactinemia: Pathophysiology and Clinical Approach.” Obstet Gynecol Int (2018): 9253083. DOI: 10.1155/2018/9253083

Gunkov, S.V., Tatarchuk, T.F., Vykhor, V.O., et al. “Provision of the balance of essential macro- and microelements in women with polycystic ovary.” Modern problems of toxicology of food and chemically safe 72.4 (2015): 51–3.

Gunkov, S.V., Tatarchuk, T.F., Zhminko, P.G., Regeda, S.I. “The effect of manganese and nickel on prolactin in women with polycystic ovary.” Georgian medical news 289.4 (2019): 21–5.

Costa, L.G., Aschner, M. ; Royal Society of Chemistry. Manganese in Health and Disease. Cambridge (2015): 632 р. DOI: 10.1039/9781782622383.

Zhang, J., et al. “The role of autophagy dysregulation in manganese-induced dopaminergic neurodegeneration.” Neurotox Res 24.4 (2013): 478–90. DOI: 10.1007/s12640-013-9392-5

Chen, P., Totten, M., Zhang, Z.“Iron and manganese-related CNS toxicity: mechanisms, diagnosis and treatment.” Expert Rev Neurother 19.3 (2019): 243–60. DOI: 10.1080/14737175.2019.1581608

Aivazidis, S., Anderson, C.C., Roede, J.R. “Toxicant-mediated redox control of proteostasis in neurodegeneration.” Curr Opin Toxicol 13 (2019): 22–34. DOI: 10.1016/j.cotox.2018.12.007

Dees W.L., Hiney, J.K., Srivastava, V.K. “Influences of Manganese on Pubertal Development.” J Endocrinol 235.1 (2017): R33–R42. DOI: 10.1530/JOE-17-0237

Office of Environmental Health Hazard Assessment (OEHHA). Proposition 65. Еvidence on the developmental and reproductive toxicity of Nickel and Nickel Compounds, July 2018. Reproductive and Cancer Hazard Assessment Branch, OEHHA, California Environmental Protection Agency. Available from: [https://oehha.ca.gov/media/downloads/crnr/nihid072718.pdf].

Forgacs, Z., Massányi, P., Lukac, N., Somosy, Z. “Reproductive toxicology of nickel – review.” J Environ Sci Health A Tox Hazard Subst Environ Eng 47.9 (2012): 1249–60. DOI: 10.1080/10934529.2012.672114

Kim, D.S., Jin, H., Anantharam, V., et al. “p73 gene in dopaminergic neurons is highly susceptible to manganese neurotoxicity.” Neurotoxicology 59 (2017): 231–9.

Liu, X., Herbison, A.E. “Dopamine Regulation of Gonadotropin-Releasing Hormone Neuron Excitability in Male and Female Mice.” Endocrinology 154.1 (2013): 340–50. DOI: 10.1210/en.2012-1602

Lee, E., Karki, P., Johnson, J. Jr, et al. “Manganese Control of Glutamate Transporters' Gene Expression.” Adv Neurobiol 16 (2017): 1–12. DOI: 10.1007/978-3-319-55769-4_1

Ma, R.E., Ward, E.J., Yeh C.L., et al. “Thalamic GABA levels and occupational manganese neurotoxicity: Association with exposure levels and brain MRI.” Neurotoxicology 64 (2018): 30–42. DOI: 10.1016/j.neuro.2017.08.013

Edmondson, D.A., Ma, R.E., Yeh, C.L., et al. “Reversibility of neuroimaging markers influenced by lifetime occupational manganese exposure.” Toxicol Sci 172.1 (2019): 181–90. DOI: 10.1093/toxsci/kfz174

Chaudhari, N., Dawalbhakta, M., Nampoothiri, L. “GnRH dysregulation in polycystic ovarian syndrome (PCOS) is a manifestation of an altered neurotransmitter profile.” Reprod Biol Endocrinol 16.1 (2018): 37. DOI: 10.1186/s12958-018-0354-x

Tatarchuk, T.F., Gunkov, S.V., Yefimenko, O.А. “Modern approaches to the diagnosis and treatment of hyperprolactinemia.” Reproductive endocrinology 1.3 (2012): 26–44. DOI: 10.18370/2309-4117.2012.3.26-44

Kong, L., Tang, M., Zhang, T., et al. “Nickel nanoparticles exposure and reproductive toxicity in healthy adult rats.” Int J Mol Sci 15.11 (2014): 21253–69. DOI: 10.3390/ijms15112125


GOST Style Citations


1.            Oyola, M.G. “Hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes: sex differences in regulation of stress responsivity,” Handa Stress 20.5 (2017): 476–94. DOI: 10.1080/10253890.2017.1369523

2.            Plant, T.M. “The hypothalamo-pituitary-gonadal axis.” J Endocrinol 226.2 (2015): T41–T54. DOI: 10.1530/JOE-15-0113

3.            Rosenfield, R.L., Ehrmann, D.A. “The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism.” Revisited Endocr Rev 37.5 (2016): 467–520. DOI: 10.1210/er.2015-1104

4.            Goodman, N.F., Cobin, R.H., Futterweit, W., et al. “American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society disease state clinical review: guide to the best practices in the evaluation and treatment of polycystic ovary syndrome - part 1.” Endocr Pract 21.11 (2015): 1291–300. DOI: 10.4158/EP15748.DSC

5.            Witchel, S.F., Oberfield, S.E., Peña, A.S. “Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls.” J Endocr Soc 3.8 (2019): 1545–73. DOI: 10.1210/js.2019-00078

6.            Tortonese, D.J. “Intrapituitary Mechanisms Underlying the Control of Fertility: Key Players in Seasonal Breeding.” Domest Anim Endocrinol 56 (Suppl) (2016): 191–203. DOI: 10.1016/j.domaniend.2016.01.002

7.            Bryant, A.S., Greenwood, A.K., Juntti, S.A., et al. “Dopaminergic inhibition of gonadotropin-releasing hormone neurons in the cichlid fish Astatotilapia burtoni.” J Exp Biol 219.24 (2016): 3861–5. DOI: 10.1242/jeb.147637

8.            Levine, S., Muneyyirci-Delale, O. “Stress-Induced Hyperprolactinemia: Pathophysiology and Clinical Approach.” Obstet Gynecol Int (2018): 9253083. DOI: 10.1155/2018/9253083

9.            Гуньков, С.В. Дослідження балансу ессенціальних макро- та мікроелементів у жінок з полікістозом яєчників/ С.В. Гуньков, Т.Ф. Татарчук, В.О. Вихор та ін. // Сучасні проблеми токсикології харчової та хімічної безпеки. – 2015. – Т. 72, № 4. – С. 51–53.

10.          Гуньков, С.В. Влияние марганца и никеля на показатели пролактина у женщин с поликистозом яичников / С.В. Гуньков, Т.Ф. Татарчук, П.Г. Жминько, С.И. Регеда // Georgian medical news. – 2019. – Т. 289, № 4. – С. 21–25.

11.          Costa, L.G., Aschner, M. ; Royal Society of Chemistry. Manganese in Health and Disease. Cambridge (2015): 632 р. DOI: 10.1039/9781782622383.

12.          Zhang, J., et al. “The role of autophagy dysregulation in manganese-induced dopaminergic neurodegeneration.” Neurotox Res 24.4 (2013): 478–90. DOI: 10.1007/s12640-013-9392-5

13.          Chen, P., Totten, M., Zhang, Z.“Iron and manganese-related CNS toxicity: mechanisms, diagnosis and treatment.” Expert Rev Neurother 19.3 (2019): 243–60. DOI: 10.1080/14737175.2019.1581608

14.          Aivazidis, S., Anderson, C.C., Roede, J.R. “Toxicant-mediated redox control of proteostasis in neurodegeneration.” Curr Opin Toxicol 13 (2019): 22–34. DOI: 10.1016/j.cotox.2018.12.007

15.          Dees W.L., Hiney, J.K., Srivastava, V.K. “Influences of Manganese on Pubertal Development.” J Endocrinol 235.1 (2017): R33–R42. DOI: 10.1530/JOE-17-0237

16.          Office of Environmental Health Hazard Assessment (OEHHA). Proposition 65. Еvidence on the developmental and reproductive toxicity of Nickel and Nickel Compounds, July 2018. Reproductive and Cancer Hazard Assessment Branch, OEHHA, California Environmental Protection Agency. Available from: [https://oehha.ca.gov/media/downloads/crnr/nihid072718.pdf].

17.          Forgacs, Z., Massányi, P., Lukac, N., Somosy, Z. “Reproductive toxicology of nickel – review.” J Environ Sci Health A Tox Hazard Subst Environ Eng 47.9 (2012): 1249–60. DOI: 10.1080/10934529.2012.672114

18.          Kim, D.S., Jin, H., Anantharam, V., et al. “p73 gene in dopaminergic neurons is highly susceptible to manganese neurotoxicity.” Neurotoxicology 59 (2017): 231–9.

19.          Liu, X., Herbison, A.E. “Dopamine Regulation of Gonadotropin-Releasing Hormone Neuron Excitability in Male and Female Mice.” Endocrinology 154.1 (2013): 340–50. DOI: 10.1210/en.2012-1602

20.          Lee, E., Karki, P., Johnson, J. Jr, et al. “Manganese Control of Glutamate Transporters' Gene Expression.” Adv Neurobiol 16 (2017): 1–12. DOI: 10.1007/978-3-319-55769-4_1

21.          Ma, R.E., Ward, E.J., Yeh C.L., et al. “Thalamic GABA levels and occupational manganese neurotoxicity: Association with exposure levels and brain MRI.” Neurotoxicology 64 (2018): 30–42. DOI: 10.1016/j.neuro.2017.08.013

22.          Edmondson, D.A., Ma, R.E., Yeh, C.L., et al. “Reversibility of neuroimaging markers influenced by lifetime occupational manganese exposure.” Toxicol Sci 172.1 (2019): 181–90. DOI: 10.1093/toxsci/kfz174

23.          Chaudhari, N., Dawalbhakta, M., Nampoothiri, L. “GnRH dysregulation in polycystic ovarian syndrome (PCOS) is a manifestation of an altered neurotransmitter profile.” Reprod Biol Endocrinol 16.1 (2018): 37. DOI: 10.1186/s12958-018-0354-x

24.          Татарчук, Т.Ф. Современные подходы к диагностике и лечению гиперпролактинемии / Т.Ф. Татарчук, С.В. Гуньков, О.А. Ефименко // Репродуктивная эндокринология. – 2012. – № 1 (3). – С. 26–44.

25.          Kong, L., Tang, M., Zhang, T., et al. “Nickel nanoparticles exposure and reproductive toxicity in healthy adult rats.” Int J Mol Sci 15.11 (2014): 21253–69. DOI: 10.3390/ijms15112125





Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)