Changes in procoagulant activity during pregnancy in women with drug addiction




pregnant women with drug addiction, procoagulant link, hemostasis systems, mother-placenta-fetal system


Objective: to study hemostatic features of procoagulant link in pregnant women with drug addiction.

Materials and methods. 156 pregnant women were examined: 96 women with drug addiction (main group) and 60 pregnant women in control group. All patients tests for hemostatic system by avaluation of total fibrinogen, prothrombin by Quick, activated partial thromboplastin time, and the mother-placenta-fetus system state. Ultrasound (Doppler ultrasound) was performed to estimate of  fetoplacental complex.

Results. Shifts of coagulation system to the hypercoagulation state in women with drug addiction were noted, it was manifested by an increase in fibrinogen, prothrombin by Quick and a decrease in activated partial thromboplastin time. Significant difference in these indicators was revealed in drug-dependent pregnant women compared with the control group (p <0.05). There were also changes in the mother-placenta-fetus system with doppler ultrasound, which manifested by a clinically significant deterioration in blood flow in the uterine arteries (p <0.05).

Conclusions. The course of pregnancy in women with drug addiction is characterized by the development of a hypercoagulable state. It causes thrombosis, diapedetic hemorrhage. This condition without correction subsequently leads to bleeding, as a result of intrauterine growth retardation, antenatal fetus death in the worst case.

Pregnant with drug addiction in the third trimester characterized hypercoagulation state, that is as indicated by an increase in fibrinogen, prothrombin by Quick and shortening of the activated partial thromboplastin time in comparison with pregnant women in the control group. A high proportion of gestational and perinatal complications was revealed in women of the main group (placental structural changes, hemodynamic disturbances of the second and third stages in the mother-placenta-fetus system and fetal growth retardation).

Author Biographies

Л. В. Суслікова, Ukrainian State Institute of Reproduction of the P.L. Shupik NMAPE, Kyiv

MD, professor at the Obstetrics, Gynecology and Reproductology Department, director

І. В. Малишева, Clinic of reproductive technology, USIR of P.L. Shupik NMAPE, Kyiv

Postgraduate student of the Obstetrics, Gynecology and Reproductology Department, obstetrician-gynecologist

В. В. Камінський, P.L. Shupyk NMAPE Kyiv City Center of Reproductive and Perinatal Medicine, Kyiv

MD, professor, corresponding member of the NAMS of Ukraine, head of the Obstetrics, Gynecology and Reproductology Department


К. В. Чайка, P.L. Shupik NMAPE, Kyiv

MD, professor of the Obstetrics, Gynecology and Reproductology Department

А. В. Камінський, Clinic of reproductive technology, USIR of P.L. Shupik NMAPE, Kyiv

MD, associate professor, head

А. В. Сербенюк, Clinic of reproductive technology, USIR of P.L. Shupik NMAPE, Kyiv

PhD, obstetrician-gynecologist


  1. Makatsaria, A.D., Chervenak, F.A., Bitsadze, V.O. High-risk pregnancy: a monograph. Moscow (2015): 930 p.
  2. Berkovskiy, A.L., et al. Screening tests for plasma hemostasis. Research Methods. Moscow (2016): 70 p.
  3. Yarovaya, G.A., et al. The internal pathway of blood coagulation: a training manual. Moscow. FGBOU DPO RMANPO (2017): 68 p.
  4. Medved, V.I. “Venous thromboembolism in obstetrics. Key points of international and national recommendations.” Medical aspects of women's health 10 (2015): 5–9.
  5. Momot, A.P., et al. “Features of vascular-platelet hemostasis at different stages of physiological pregnancy.” Medical Alphabet 1.2 (2014): 27–31.
  6. Orazmuradov, A.A., Komarova, E.E., Zlatovratskaya, T.V., et al. “Psychoactive substances and pregnancy.” Vestnik RUDN, Medicine series 7 (2009): 316–25.
  7. Pavlovskaya, Y.M., Vorobyova, N.A. “Fibrinogen and factor XIII during pregnancy.” Journal of Medical and Biological Research 1 (2015): 68–75.
  8. Wismont, F.I., et al. Pathological physiology: workbook. Minsk. BSMU (2016): 194 p.
  9. Podolskyi, V.V., Kasatkina, T.O. “Sexual dysfunction in women with drug addiction.” Health Women No. 2 (48) 2010, S. 65-67.
  10. Putilova, N.V., Nesterova, E.A., Pestryaeva, L.A. “Evaluation of the hemocoagulation system in pregnant women with placental insufficiency and their newborns.” Russian Bulletin of the Obstetrician-Gynecologist 17.1 (2017): 9–13. DOI: 10.17116/rosakush20171719-13
  11. Serdiuk, O.O., Burlaki, V.V. Studies on etiology, prevention and treatment of chemical deposits: an outline of the main articles. Part 1. Manual. Kharkiv. Disa plus (2015).
  12. Chonko, O.Y., Korchinska, O.O. “Features of the hemostasis system in pregnant women with a premature detachment of a normally located placenta in history.” Problems of clinical pediatrics 2–3 (2018): 82–6.
  13. Shishonok, A.I., Scherbakova, I.G., Grebennikova, I.V. “Modern aspects of hemostasis.” International Student Scientific Bulletin. Electronic scientific journal, Penza 2 (2015): 123–6.
  14. Karlsson, O. “Haemostasis during pregnancy, labour and postpartum haemorrhage.” Thesis abstract for MD degree. Goteborgs Universitet (2014). Available from: [], last accessed Apr 30, 2020.
  15. Ovchinnikov, V.V., et al. “Adaptive changes in plasma hemostasis and its reference values during physiological pregnancy in women of the Kirov region.” Vyatskiy meditsinskiy vestnik 2.50 (2016): 39–45.
  16. Shamray, V.S., et al. “Pregnancy against the background of diseases of the blood system: risks, management tactics, prospects.” Glavnyi vrach Uga Russia 1.53 (2017): 13–8.
  17. Ozolinya, L.A., Ovsepyan, N.R. “Correction of changes in hemostasis with habitual miscarriage during a chronic viral infection.” Meditsynskiy sovet 13 (2017): 110–7.
  18. Bates, S.M., et al. “Guidance for the treatment and prevention of obstetric-associated venous thromboembolism.” Journal of thrombosis and thrombolysis 41.1 (2016): 92–128.
  19. Guzovskaya, E.V., Serebrennikova, S.N. “Pathogenetic features of disseminated intravascular coagulation syndrome of various etiologies.” Patologicheskaya fiziologiya i eksperimental'naya terapiya 61.2 (2017): 76–81.
  20. Asakura, Hidesaku. “Classifying types of disseminated intravascular coagulation: clinical and animal models.” Journal of intensive care 2.1 (2014): 1–7.
  21. Wada Hideo, Takeshi Matsumoto, Yoshiki Yamashita. “Diagnosis and treatment of disseminated intravascular coagulation (DIC) according to four DIC guidelines.” Journal of Intensive Care 2.1 (2014): 1–8.
  22. Kalinin, R.E., et al. “Effect of activity of factors of the internal coagulation cascade and hemostatic markers of endothelial dysfunction on thrombotic complications in patients with atherosclerotic diseases of the peripheral arteries.” Novosti Khirurgii 25.6 (2017): 643–54.
  23. Berkovsky, A.L., et al. External coagulation pathway. Research methods: methodological guide. Moscow (2016): 70 p.
  24. Volkova, S.A., Borovkov, N.N. The basics of clinical hematology: a training manual. Nizhny Novgorod. Publishing House of the Nizhny Novgorod State Medical Academy (2013): 400 p.
  25. Glinkin, E.I., Odinokova, A.A. “Assessment of the functional state of the hemostatic system.” Tambov University Reports. Series: Natural and Technical Sciences 21.6 (2016): 2334–9.
  26. Marchenko, A.I., et al. “Investigation of the physical properties of blood and changes in the coagulation link of hemostasis, DIC.” Khirurg 6 (2016): 30–5.
  27. Rushchenko, I.P. Sociology of Crime. Kharkiv. National University of Internal Affairs (2006): 370 p.



How to Cite

Суслікова, Л. В., Малишева, І. В., Камінський, В. В., Чайка, К. В., Камінський, А. В., & Сербенюк, А. В. (2020). Changes in procoagulant activity during pregnancy in women with drug addiction. REPRODUCTIVE ENDOCRINOLOGY, (52), 49–53.



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