Changes in procoagulant activity during pregnancy in women with drug addiction

Authors

DOI:

https://doi.org/10.18370/2309-4117.2020.52.49-53

Keywords:

pregnant women with drug addiction, procoagulant link, hemostasis systems, mother-placenta-fetal system

Abstract

Objective: to study hemostatic features of procoagulant link in pregnant women with drug addiction.

Materials and methods. 156 pregnant women were examined: 96 women with drug addiction (main group) and 60 pregnant women in control group. All patients tests for hemostatic system by avaluation of total fibrinogen, prothrombin by Quick, activated partial thromboplastin time, and the mother-placenta-fetus system state. Ultrasound (Doppler ultrasound) was performed to estimate of  fetoplacental complex.

Results. Shifts of coagulation system to the hypercoagulation state in women with drug addiction were noted, it was manifested by an increase in fibrinogen, prothrombin by Quick and a decrease in activated partial thromboplastin time. Significant difference in these indicators was revealed in drug-dependent pregnant women compared with the control group (p <0.05). There were also changes in the mother-placenta-fetus system with doppler ultrasound, which manifested by a clinically significant deterioration in blood flow in the uterine arteries (p <0.05).

Conclusions. The course of pregnancy in women with drug addiction is characterized by the development of a hypercoagulable state. It causes thrombosis, diapedetic hemorrhage. This condition without correction subsequently leads to bleeding, as a result of intrauterine growth retardation, antenatal fetus death in the worst case.

Pregnant with drug addiction in the third trimester characterized hypercoagulation state, that is as indicated by an increase in fibrinogen, prothrombin by Quick and shortening of the activated partial thromboplastin time in comparison with pregnant women in the control group. A high proportion of gestational and perinatal complications was revealed in women of the main group (placental structural changes, hemodynamic disturbances of the second and third stages in the mother-placenta-fetus system and fetal growth retardation).

Author Biographies

Л. В. Суслікова, Ukrainian State Institute of Reproduction of the P.L. Shupik NMAPE, Kyiv

MD, professor at the Obstetrics, Gynecology and Reproductology Department, director

І. В. Малишева, Clinic of reproductive technology, USIR of P.L. Shupik NMAPE, Kyiv

Postgraduate student of the Obstetrics, Gynecology and Reproductology Department, obstetrician-gynecologist

В. В. Камінський, P.L. Shupyk NMAPE Kyiv City Center of Reproductive and Perinatal Medicine, Kyiv

MD, professor, corresponding member of the NAMS of Ukraine, head of the Obstetrics, Gynecology and Reproductology Department

Head

К. В. Чайка, P.L. Shupik NMAPE, Kyiv

MD, professor of the Obstetrics, Gynecology and Reproductology Department

А. В. Камінський, Clinic of reproductive technology, USIR of P.L. Shupik NMAPE, Kyiv

MD, associate professor, head

А. В. Сербенюк, Clinic of reproductive technology, USIR of P.L. Shupik NMAPE, Kyiv

PhD, obstetrician-gynecologist

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Published

2020-05-13

How to Cite

Суслікова, Л. В., Малишева, І. В., Камінський, В. В., Чайка, К. В., Камінський, А. В., & Сербенюк, А. В. (2020). Changes in procoagulant activity during pregnancy in women with drug addiction. REPRODUCTIVE ENDOCRINOLOGY, (52), 49–53. https://doi.org/10.18370/2309-4117.2020.52.49-53

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