Role of the hormonal system “Vitamin D/Vitamin D receptors” in the formation of some pregnancy complications




vitamin D hormone, vitamin D receptors, pregnancy complications, preeclampsia, placental dysfunction


Introduction. The hormonal system “vitamin D/vitamin D receptors” (VD/VDR) is involved in the regulation of numerous physiological processes. VD lack or deficiency is associated with a number of different diseases, including pregnancy complications.

Purpose of the study: to determine VD status and its effect on the course of the gestational process in women from the southern region of Ukraine.

Materials and methods. 459 women were examined, 318 (69.3%) of them were the main group and 141 (30.7%) were the comparison group.

In addition to standard general clinical examinations, ELISA on a COBAS Integra 400 Plus analyzer (Roche Diagnostics, Switzerland) the VD level was determined in the blood.

Results and discussion. 49.9% of the pregnant women in the main group had insufficient VD level (25.45 ± 4.63 ng/ml), in 19.4% it corresponded to a deficit (15.28 ± 4.78 ng/ml). VD concentration in the comparison group was 43.38 ± 9.67 ng/ml (p <0.01). Significantly more frequent pregnancy complications in the main group were threatening abortion (45.6% VS 9.9%; F = 0.00001; p <0.01), preeclampsia (13.5% VS 2.8%; F = 0.0093; p <0, 05), placental dysfunction (32% VS 7%; F = 0.00001; p <0.01), vaginal dysbiosis (64.4% VS 18.4%; F = 0.00001; p <0.01), pregnant anemia (43.7% VS 20.6%; F = 0.0008; p <0.01) and signs of inflammation of the amniotic membranes (38.3% VS 13.4%). Syndrome of intrauterine growth retardation diagnosed in 9% women in the main group; in the comparison group none case was noted.

Conclusion. 70% of pregnant women in Odesa region have a lack or deficiency of VD. Pregnancy course is characterized by a significantly greater frequency of preeclampsia (4.8 times more often), placental dysfunction (4.5 times), threat of miscarriage (4.6 times more often), intrauterine infection (2.8 times more often), gestational anemia (2.5 times more). It seems promising to conduct further research on the possibility of preventing complications of the gestational process by correcting VD status.

Author Biographies

G. S. Manasova, Odesa National Medical University, Odesa

MD, professor, Department of Obstetrics and Gynecology No. 2

A. G. Andrievsky, Odesa National Medical University, Odesa

MD, professor, head of the Department of Obstetrics and Gynecology No. 2

N. V. Didenkul, KU “City Clinical Hospital No. 1” Odesa National Medical University, Odesa

Obstetrician-gynecologist of the gynecological department

Graduate student of the Department of Obstetrics and Gynecology No. 2

I. V. Shpak, Odesa National Medical University Communal non-commercial enterprise “Maternity hospital No. 5”, Odesa

MD, professor, Department of Obstetrics and Gynecology No. 2


M. I. Turchyn, Odesa National Medical University, Odesa

PhD, associate professor of the Department of professional pathology, clinical laboratory and functional diagnostics

N. V. Kuzmin, Communal non-commercial enterprise “Maternity hospital №5” Odesa National Medical University, Odesa

Obstetrician-gynecologist of the 2nd obstetric department

Graduate student of the Department of Obstetrics and Gynecology No. 2


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