Features of the exchange of connective tissue and certain microelements in pregnant women with a risk of postterm pregnancy





postterm pregnancy, cervix, calcium, vitamin D, connective tissue


Purpose of the study: to investigate the serum content of certain trace elements and synthesis markers (Total P1NP) and collagen resorption (β-CrossLaps) in pregnant women with a risk of postterm pregnancy and their role in this pathology.

Materials and methods. Main group included 80 pregnant women with a risk of postterm pregnancy. Control group consisted of 34 pregnant women without a risk of postterm pregnancy demostrating physiologic cervical maturation. Enzyme immunoassay was used for measurement of synthesis markers (Total P1NP - N-terminal propeptide of type I collagen), connective tissue resorption (ß-CrossLaps), and trace elements - Na, K, Mg, P, total and ionized Ca.

Results. Significant decrease in the concentration of Total P1NP was noted In pregnant women with a risk of postterm pregnancy compared with the control group (50.90 ± 4.27 ng/ml, p <0.05). The average value of connective tissue resorption marker β-CrossLaps in pregnant women of the main group was significantly higher than in the control ones (0.420 ± 0.02 ng/ml and 0.300 ± 0.02 ng/ml respectively). The total Ca was 1.98 ± 0.03 mmol/L that is 7.9% and 10.4% less than the lower limit of the physiological norm and in the control group (2.21 ± 0.04 mmol/l, p < 0.05) respectively. Mg in the main group was 0.68 ± 0.02 mmol/L, that is at the lower limit of the norm, and 20.9% less than in the control group (0.86 ± 0.03 mmol/L; < 0.05). The total serum vitamin D in pregnant women of the main group was 25.4% less than in the control group (23.62 ± 1.61 ng/ml, p <0.05).

Conclusions. An imbalance of the most microelements significant for the normal functioning of connective tissue and processes of transmission of nervous excitation in combination with a deficiency of vitamin D contributes to a cascade of reactions that inhibit the timely restructuring of the cervix structure before childbirth. Pregnant women with a risk of overexposure are characterized by a predominance of type I collagen resorption processes over its synthesis processes, which is probably one of the reasons for the insufficient maturation of the cervix on the eve of childbirth.

Author Biographies

І. А. Жабченко, SI “Academician O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”, Kyiv

MD, professor, сhief of the Department of pathology of pregnancy and childbirth

І. С. Ліщенко, SI “Academician O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”, Kyiv

Researcher, Department of pathology of pregnancy and childbirth

В. В. Буран, M.I. Pirogov Vinnytsia National Medical University, Vinnytsia

PhD, associate professor, Department of obstetrics and gynecology No. 1


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How to Cite

Жабченко, І. А., Ліщенко, І. С., & Буран, В. В. (2020). Features of the exchange of connective tissue and certain microelements in pregnant women with a risk of postterm pregnancy. REPRODUCTIVE ENDOCRINOLOGY, (51), 37–41. https://doi.org/10.18370/2309-4117.2020.51.37-41



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