Sclerosis of the mammary arteries in perimenopausal women as an early marker of atherosclerosis
Keywords:sclerosis of mammary arteries, atherosclerosis, mammary gland, menopausal syndrome, mammography
Purpose of the study. To assess the sclerosis of mammary arteries (SMA) frequency depending on the age and duration of menopause by conducting mammography in the studied women of perimenopausal age.
Materials and methods. To examine the morphological and functional state of the mammary gland was performed a clinical examination of the mammary glands which included examination, palpation, and bilateral mammography. Together with the assessment of the state of the mammary gland, mammary arteries were evaluated for their sclerosis. The severity of menopausal syndrome was assessed using the Menopausal Rating Scale. 584 women were examined with ultrasound and divided into groups: Group I – women 40–45 years aged and Group II – women 46–51 years aged.
Results of the study. SMA was more common in older women – 3.7% in Group I compared with 8.4% in Group II (p <0.05). Certain patterns have also been identified between the SMA incidence and the menopausal symptoms presence. Incidence of SMA was greater in both younger and older women with manifestations of menopausal syndrome than in women without manifestations of menopausal syndrome.
The study identified additional risk factors for the SMA development as an early marker of atherosclerosis, among which is duration of menopause, severity of menopausal syndrome, presence of concomitant breast pathology, overweight and a positive family history of atherosclerosis.
Conclusions. SMA identification during mammography is an important additional advantage of examining women and requires mandatory cardiac support and the introduction of prophylactic agents for cardiovascular pathology. Authors’ data confirm the importance of an interdisciplinary approach and the benefits of using modern methods for diagnosing and preventing diseases during the perimenopause period in order to improve the quality and longevity of women.
Matthews, K.A., Crawford, S.L., Chae, C.U., et al.“Are changes in cardiovascular disease risk factors in midlife women due to chronological aging or to the menopausal transition?” J Am Coll Cardiol 54 (2009): 2366–73.
Tatarchuk, T.F., Yefimenko, O.A., Islamova, A.O. “Menopause: A New Look at an Old Problem.” Reproductive Endocrinology 1.9 (2013): 7–12.
Mitchenko, O.I., Romanov, V.Y., Iliushina, G.Y. “Disorders of lipid metabolism and surrogate markers of atherosclerosis in patients with hypertension on the background of physiological and postsurgical menopause.” Ukrainian Cardiology Journal 5 (2015): 79–84.
Birhaeuse, M., Genazzani, A.R., eds.Pre-menopause, Menopause and Beyond. Volume 5: Frontiers in Gynecological Endocrinology. Springer (2018): 327 p.
De Villiers, T., Tatarchuk, T.F., et al. “National consensus on the management of patients in menopause.” Reproductive endocrinology 1.27 (2016): 8–25.
Kaminskyi, V.V., Antypkin, Y.G., Tatarchuk, T.F. “Saving the quality of life and social activity of women in the postproductive period. Resolution of the Expert Council on the implementation of the social information project.” Reproductive endocrinology 1.27 (2016): 9–12.
El Khoudary, S.R., Wang, L., Brooks, M.M., et al. “Increase HDL-C level over the menopausal transition is associated with greater atherosclerotic progression.” J Clin Lipidol 10 (2016): 962–9.
El Khoudary, S.R., Hutchins, P.M., Matthews, K.A., et al. “Cholesterol efflux capacity and subclasses of HDL particles in healthy women transitioning through menopause.” J Clin Endocrinol Metab 101 (2016): 3419–28.
Matthews, K.A., El Khoudary, S.R., Brooks, M.M., et al. “Lipid changes around the final menstrual period predict carotid subclinical disease in postmenopausal women.” Stroke 48 (2017): 70–6.
Kataoka, M., Warren, R., Luben, R., et al. “How predictive is breast arterial calcification of cardiovascular disease and risk factors when found at screening mammography?” AJR Am J Roentgenol 187 (2006): 73–80.
Tatarchuk, T.F., Yefimenko, O.O. “On the Prevention of Breast Pathology.” Reproductive Endocrinology 6.8 (2012): 10–6.
Perkins, M.S., Louw-du Toit, R., Africander, D. “Hormone therapy and breast cancer: emerging steroid receptor mechanisms.” Journal of Molecular Endocrinology 61.4 (2018). DOI: 10.1530/JME-18-0094
Xie, D., Dahl-Smith, J., Du Bose, J., et al. “Counseling patients about hormone therapy and alternatives for menopausal symptoms.” Osteopathic Family Physician (2014): 615–21.
Abi Rafeh, N., Castellanos, M.R., Khoueiry, G., et al. “Association between coronary artery disease diagnosed by coronary angiography and breast arterial calcifications on mammography: metaanalysis of the data.” J Womens Health (Larchmt) 21 (2012): 1053–8.
Yefimenko, O.O., Retunska, I.M., Zelenko, O.S. “Reproductive, clinical and biological markers of perimenopause.” Reproductive endocrinology 6.44 (2018): 24–30.
Rotter, M.A., Schnatz, P.F., Currier, A.A. Jr., et al. “Breast arterial calcifications (BACs) found on screening mammography and their association with cardiovascular disease.” Menopause 15 (2008): 276–81.
Shah, N., Chainani, V., Delafontaine, P., et al. “Mammographically Detectable Breast Arterial Calcification and Atherosclerosis.” Cardiol Rev 22.2 (2014): 69–78.
Ahn, K.J., Kim, Y.J., Cho, H.J., et al. “Correlation between breast arterial calcification detected on mammography and cerebral artery disease.” Arch Gynecol Obstet 284 (2011): 957–64.
Micheletti, R.G., Fishbein, G.A., Currier, J.S., et al. “Monckeberg sclerosis revisited: a clarification of the histologic definition of Monckeberg sclerosis.” Arch Pathol Lab Med 132 (2008): 43–7.
Ferreira, J.A., Pompei, L.M., Fernandes, C.E., et al. “Breast arterial calcification is a predictive factor of cardiovascular disease in Brazilian postmenopausal women.” Climacteric 12 (2009): 439–44.
Schnatz, P.F., Marakovits, K.A., O’Sullivan, D.M. “The association of breast arterial calcification and coronary heart disease.” Obstet Gynecol 117 2 Pt 1 (2011): 233–41.
Yeonyee E. Yoon, Kyoung Min Kim, Jong Soo Han, et al. “Prediction of Subclinical Coronary Artery Disease With Breast Arterial Calcification and Low Bone Mass in Asymptomatic Women Registry for the Women Health Cohort for the BBC Study.” JACC: Cardiovascular Imaging 12.7.1 (2019).
Benjamin, E.J., Muntner, P., Alonso, A., et al. “American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2019 update: a report from the American Heart Association.” Circulation 139 (2019): e56–e66.
De Villiers, T.J., Pines, A., Panay, N., et al.“Updated 2013 International Menopause Society recommendations on menopausal hormone therapy and preventive strategies for midlife health.” Climacteric 16.3 (2013): 316–37.
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