Outcomes after hysteroscopic repair of symptomatic isthmocele: a single center experience in Ukraine





isthmocele, transvaginal ultrasound, adenomyosis, abnormal uterine bleeding, dysmenorrhea, hysteroscopy


Рurpose of the study was to evaluate the influence of Isthmocele (IC) hysteroscopic repair on symptoms (abnormal uterine bleeding, dysmenorrhea) in premenopausal patients with residual myometrium thickness more than 2.4 mm and to assess myometrial thickness 3, 6 and 12 month post surgery.

Materials and methods. It was a prospective case series of symptoms evaluation and myometrium thickness following hysteroscopic IC repair in premenopausal women not willing to conceive. Diagnosis of IC was based on 2D transvaginal ultrasound and symptom evaluation. Symptom frequency and residual myometrium thickness by ultrasound were evaluated before hysteroscopic repair and after 3, 6 and 12 months after it in patients with IC as single possible cause of symptoms.

Results. In the period from January 2017 to January 2018 there were 32 cases of symptomatic IC in premenopausal women. 8 (25%) of them had coexisting uterine pathology that could cause AUB, these women were not included in hysteroscopic treatment efficacy analysis. Thus 24 patients with residual myometrium thickness of more than 2.4mm and not willing to conceive underwent hysteroscopic repaire of IC. Three months after surgery, most patients reported a complete relief of symptoms: abnormal uterine bleeding reduced from 33.3% (8 patients) to 4.2% (1 patient); intermenstrual bleeding form 75% (18 patients) to 12.5% (3 patients); dysmenorrhea – from 91.7% (22 patients) to 29.2 (7 patients). This effect was even more prominent after 6 and 12 months. Average residual myometrium thickness values changed in the following way: 3.6 ± 0.9 before surgery; 4.9 ± 1.2 mm after 3 months; 5.9 ± 1.0 mm after 6 month and 6.5 ± 1.1 mm after 12 months.

Conclusion. Hysteroscopic repair of IC is a technically feasible, safe and highly effective procedure for symptoms (abnormal uterine bleeding, pelvic pain, dysmenorrhea) in women with other uterine pathology excluded and not willing to conceive. Efficacy and specific features technical performance and medical treatment in cases with coexisting adenomyosis and other uterine pathology are to be defined in future studies as such cases are frequent.

Author Biographies

T. F. Tatarchuk, SI “O.M. Lukyanova IPOG of the NAMS of Ukraine”; SRI “CIMT of the NAS of Ukraine”, Kyiv

MD, professor, corresponding member of the NAMS of Ukraine, deputy director for research work, head of the Endocrine Gynecology Department

N. V. Kosei, SI “O.M. Lukyanova IPOG of the NAMS of Ukraine”, leading researcher at the SRI “CIMT of the NAS of Ukraine”, Kyiv

MD, chief researcher at the Endocrine Gynecology Department

B. V. Khabrat, SRI “Scientific and Practical Center of Preventive and Clinical Medicine”, The State Management of Affairs, Kyiv

PhD, leading researcher at the Research Department of Minimally Invasive Surgery

T. M. Tutchenko, SI “O.M. Lukyanova IPOG of the NAMS of Ukraine”; SRI “CIMT of the NAS of Ukraine”, Kyiv

PhD, researcher of the Endocrine Gynecology Department

L. М. Zenkina, SRI “CIMT of the NAS of Ukraine”, Kyiv

Head of anesthesiology department

M. I. Hlamazda, SI “O.M. Lukyanova IPOG of the NAMS of Ukraine”, Kyiv

PhD, postgraduate student

N. M. Yevtushenko, Medical centre “Verum”, Kyiv

Highest category obstetrician-gynecologist, head of treatment and surgical department


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How to Cite

Tatarchuk, T. F., Kosei, N. V., Khabrat, B. V., Tutchenko, T. M., Zenkina L. М., Hlamazda, M. I., & Yevtushenko, N. M. (2019). Outcomes after hysteroscopic repair of symptomatic isthmocele: a single center experience in Ukraine. REPRODUCTIVE ENDOCRINOLOGY, (50), 8–11. https://doi.org/10.18370/2309-4117.2019.50.8-11




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