State of the pheto-placenteral complex in pregnant women with obstetric pathology and burdened reproductive history
Keywords:feto-placental complex, hormones, pregnancy, obstetric pathology, burdened reproductive history
Purpose of the study. To study the fetoplacental system (FPS) status in women with obstetric pathology and a burdened reproductive history.
Materials and methods. The study included 500 pregnant women who were divided into four groups: I – 150 women with an uterus scar, II – 150 women after assisted reproductive technologies, III – 150 women with anomalies in labor, 0 – 50 healthy pregnant women without obstetric pathology and without burdened reproductive history. The level of PPS hormones was determined in serum, depending on type of obstetric pathology and characteristics of the reproductive history. The study of hormonal indicators was carried out in the pregnancy dynamics. Fetus state was evaluated with a cardiotocographic study.
Results. Increase in placental lactogen level was observed in the pregnancy dynamics in women with obstetric pathology and a burdened reproductive history, but its growth in 21–30 and 31–40 weeks was less than in pregnant women without obstetric pathology and without a burdened reproductive history. Dynamics of the estriol and estradiol levels in the blood in all groups in the gestational age of 21–30 weeks was characterized by approximately the same levels of decrease compared with healthy pregnant women without obstetric complications. Decrease in progesterone secretion was observed in all pregnant women with obstetric pathology and burdened reproductive history. Dynamics of it level in the blood serum during pregnancy up to 20 weeks, 21–30 weeks and 31–40 weeks showed a decrease. This is a reflection of changes in the PPS state in general and leads to fetus deterioration.Conclusions. There is a feto-placental insufficiency in pregnant women with obstetric pathology and with a burdened reproductive history that is manifested by inhibition of the hormonal function of the feto-placental complex and proceeds against the background of fetal heart rate changes. Identified changes require the preventive and therapeutic measures aimed at correcting the fetus impaired condition and changes in FPS
- Tarasova, N.S. Structural and functional features of placenta in young firstborn women. Thesis for PhD degree, specialty 14.00.01. Moscow (2007): 93 p.
- Yudochkina, I.V. Reserves of reduction of perinatal morbidity and mortality in first-born older age groups. Thesis for PhD degree, specialty 14.00.01. Moscow (2008): 114 p.
- Vdovichenko, Y.P., Dudka, S.V. “Ultrasound diagnostics of clogging fetal growth against the background of placental insufficiency in groups with a high rhizic.” In: Exography in perinatology and gynecology. Kryvyi Rig (2013): 25–27.
- Zaporozhan, V.M., Danilenko, L.I., Makulkin, R.F. “Placental insufficiency and and its effect on the fetus.” Odesa medical journal 4 (2009): 82–4.
- Romanenko, T.G., Tkachenko, A.V. “Immunological aspects of prevention, prognosis and treatment of miscarriage.” Pediatrics, obstetrics and gynecology 6 (2010): 117–119.
- Pisareva, S.P., Zabolotnaya, M.L., Vorobyova, I.I. “The clinical course of pregnancy and the consequence of childbirth in women with placental insufficiency.” Women's Health 3.11 (2012): 7–9.
- Zarubina, E.N., Bermisheva, O.A., Smirnova, A.A. “Modern approaches to the treatment of chronic placental insufficiency.” Problems of reproduction 5 (2013): 61–3.
- Frauenschuh, I., Wirbelauer, J., Karl, S. Prognosefaktoren des perinatalen Kurzzeitergebnisses bei schwerer Plazentainsuffizienz mit dopplersonografisch enddiastolischem Null und Rückfluss in der Art. Umbilicalis.” Z Geburtshilfe Neonatol 219.01 (2015): 28–36.
- Malanchuk, L.M., Kryvitska, G.A. “Reproductive health of women (literature review) and statistical analysis of its individual indicators in the Kherson region.” Current issues of pediatrics, obstetrics and gynecology 1 (2016): 83–5.
- Stepankovskaya, G.K., Gordeeva, G.D. Obstetrics and Gynecology. Moscow. Eksmo-Press (2010): 400 p.
- Caughey, A.B., Stotland, N.E., Washington, A.E., Escobar, G.J. “Who is at risk for prolonged and postterm pregnancy?” Am J Obstet Gynecol 200.6 (2009): 683.
- Kalinovska, I.B. Placental insufficiency: pathogenesis, early diagnosis, tactics of vaginosis and rhodorrhogenesis. Thesis abstract for MD degree, specialty 14.01.01. Kyiv (2008) 32 p.
- Kalinovska, I.V., Podolskyi, V.V. Placental insufficiency: pathogenesis, early diagnosis, tactics of tactics of pregnancy and delivery management. Chernivtsi (2009): 304 p.
- Shcherbakov, A.Y., Gladkova, T.A., Shcherbakov, V.Y., Novikova, O.O. “Functional state of fetoplacental complex in pregnant women after cesarean section.” Pathology 1.24 (2012): 42–4.
- Pirogova, V.І., Ohabska, I.I. “Pathogenetic substantiation of the correction of placental insufficiency in pregnant women with complicated gestational process.” Reproductive health of woman 3 (2011): 62–4.
- Chepka, Y.L. “Prediction of fetoplacental insufficiency based on statistical multifactor computer analysis.” Ukrainian Medical Bulletin 1.33 (2010): 105–8.
- Karaseva, Y.V. “Diagnosis of placental dysfunction by psychoneuroimmunological parameters.” Bulletin of new medical technologies IX.4 (2011): 7–9.
- Dorotenko, A.Y. “Ultrasonic placental risk factors for the development of placental insufficiency.” Prenatal diagnostics 4.3 (2012): 237–9.
- Clifford, G., Sameni, R., Ward, J., et al. “Clinically accurate fetal ECG parameters acquired from maternal abdominal sensors.” Am J Obstet Gynecol 205 (2011): 47.e1-47.e5.
- Ortiz, M.R., Echeverria, J.C., Alvarez-Ramirez, J., et al. “Effects of fetal respiratory movements on the short-term fractal properties of heart rate variability.” Med Biol Eng Comput 51.4 (2013): 441–8.
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