The role of macro- and microelements in the pathogenesis of polycystic ovary




macroelements, microelements, toxicity, polycystic ovary syndrome, pathogenesis


PCOS is a common disease that occurs in 3–15% of women of childbearing age, according to various authors. Despite numerous studies, there are still many conflicting views on the etiology of PCOS, as well as on the diagnostic criteria and treatment methods for this disease.

Purpose of the study. Evaluation of macro- and microelements in blood serum of women with PCOS and study of their role in development of this disease.

Materials and methods. The control group consisted of 38 healthy women. The study group included 52 women with PCOS. In both groups magnesium (Mg), copper (Cu), manganese (Mn), nickel (Ni), zinc (Zn), chromium (Cr), selenium (Se), and vanadium (V) were determined in blood serum. Samples were analyzed by inductively coupled plasma mass spectrometry. Statistical significance of the results was evaluated using the Kolmogorov-Smirnov, Mann-Whitney criteria, Student’s t-test.

Results of the study. Increase in Mn, Ni, and Zn was found in women with PCOS an. Cu, Mg, Cr, Se, V value in both groups were the same. The medians of the Mn, Ni and Cr level exceed the permissible standards in both groups of women, which indicate an increased exposure these metals on the population. Mn and Ni were significantly higher in women with PCOS compared to the control group. The authors of the study suggested that an increased exposure level of Mn and Ni may be the cause or background factor for the PCOS.

Conclusion. Higher levels of manganese, nickel and zinc in the blood serum in women with PCOS compared with the control group were found. An increased manganese and nickel exposure on the body can cause PCOS. Increase in zinc in women with PCOS is likely due to the body's adaptive response.

Author Biographies

М. Г. Проданчук, SE “L.I. Medved’s Research Center of Preventive Toxicology, Food and Chemical Safety of the MoH of Ukraine”, Kyiv

MD, professor, corresponding member of the NAMS of Ukraine, director

Т. Ф. Татарчук, SI “O.M. Lukyanova IPOG of the NAMS of Ukraine”, Kyiv

MD, professor, corresponding member of the NAMS of Ukraine, deputy director for research work, head of the Endocrine Gynecology Department

С. В. Гуньков, SE «L.I. Medved's Research Center of Preventive Toxicology, Food and Chemical Safety of the MoH of Ukraine», Kyiv

PhD, leading researcher

П. Г. Жмінько, SE “L.I. Medved's Research Center of Preventive Toxicology, Food and Chemical Safety of the MoH of Ukraine», Kyiv

MD, head of department “Institute of Experimental Toxicology and Medico-biological Researches”

С. І. Регеда, SI “O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”, Kyiv

PhD, senior researcher of the Endocrine Gynecology Department

М. І. Римарчук, ESIPE Ivano-Frankivsk National Medical University, Ivano-Frankivsk

Associate professor at the Obstetrics and Gynecology Department


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How to Cite

Проданчук, М. Г., Татарчук, Т. Ф., Гуньков, С. В., Жмінько, П. Г., Регеда, С. І., & Римарчук, М. І. (2019). The role of macro- and microelements in the pathogenesis of polycystic ovary. REPRODUCTIVE ENDOCRINOLOGY, (48), 22–25.