New patterns of menstrual disorders’ treatment – unification of the method


  • О. В. Грищенко Kharkiv Medical Academy of Postgraduate Education, Ukraine
  • В. В. Бобрицкая Kharkiv Medical Academy of Postgraduate Education, Ukraine



menstrual cycle disorders, monotherapy, Tazalok


Effective treatment of menstrual cycle disorders, elimination of polypragmasia, and unification of the method in various types of menstrual disorders is an important task of modern science and practice.

The aim of the study was to optimize the treatment of menstrual disorders with drugs of plant origin, by comparing the clinical efficacy of TazalokTM and Vitex agnus-castus.

Design: a comparative study.

Materials and methods. Under the supervision there were 60 patients aged 23–37 years with various forms of menstrual disorders, divided into two groups of 30 people, in accordance with therapy. Patients of the main group I received TazalokTM for treatment of menstrual disorders, 45 drops 2 times a day, patients II (comparison group) received 40 drops of Vitex agnus-castus 1 time per day. The course of therapy was 3 months. The main group and the comparison group were divided into two subgroups of 15 patients, in accordance with the peculiarities of the menstrual disorders. Subgroup IA of main group – patients with heavy bleeding during the menstrual period, IВ – patients with scanty menstruation. In the comparison group: IІА – heavy menstrual bleeding, IIB – meager menstrual bleeding. All patients underwent a hormonal study before and after 3 months of treatment, sonographic monitoring, evaluation of subjective complaints.

Results. There was normalization of the level of steroid hormones, the thyroid gland hormones. A significant decrease in cortisol levels was in patients taking TazalokTM. Sonographic characteristics of the pelvic organs, mammary glands, and the thyroid gland in patients treated with TazalokTM showed a positive trend, the disappearance of the pathological vascularization of target organs. Decrease in complaints by 2–3 weeks of taking.

Conclusion. TazalokTM is an effective medicine for the treatment of various clinical forms of menstrual cycle disorders, has a wider range of effects compared with Vitex agnus-castus.

Author Biographies

О. В. Грищенко, Kharkiv Medical Academy of Postgraduate Education

MD, professor, head of the Perinatology, Obstetrics and Gynecology Department

В. В. Бобрицкая, Kharkiv Medical Academy of Postgraduate Education

PhD, associate professor at the Perinatology, Obstetrics and Gynecology Department


  1. World Health Organization. International Statistical Classification of Diseases and Related Health Problems of the Tenth Review (ICD-10). Geneva. WHO. Available from: [], last accessed May 23, 2019.
  2. Vovk, I.B., Chubei, G.М., Kondratiuk, V.K., Podoliaka, D.V. “Ovarian tumor lesions: etiology, pathogenesis, diagnosis and treatment” Woman’s Health 2.78 (2013):112–7.
  3. Karpenko, N.A., Koreneva, E.M., Brechka, N.M., et al. “Experimental substantiation of the clinical use of the drug Tazalok in stress-induced disorders of female reproductive health.” Experim Clіn Medicine 1 (2010): 57–63.
  4. Kuznetsova, I., Uspenskaya, Y., Dil, V., Grineva, A. ”Use of plant dopaminomimetics in adolescents and young women with impaired menstrual cycle.” Obstetrics and Gynecology 10 (2015): 1–8.
  5. Pankiv, V.I. “The influence of thyroid disorders upon the female reproductive function. modern possibilities of phytotherapy.” Reproductive endocrinology 1.27 (2016): 52¬–7.
  6. Prilepskaya, V.N., Dovletkhanova, E.R. “Premenstrual syndrome and the quality of life of woman. Effectivness of herbal drugs.” Reproductive endocrinology 1.39 (2018): 76–80.
  7. Reznikov, A.G. “Neuroendocrine system as therapeutic target of vitex agnus castus fruit extract for premenstrual syndrome.” Reproductive еndocrinology 1.21 (2015): 19–23.
  8. Tatarchuk, T.F. Kalugina, L.V. “On the treatment of endometrial hyperplasia.” Reproductive Endocrinology 2.4 (2012): 88–92.
  9. Berga, S., Genazzani, A.R., Naftolin, F., Petraglia, F., eds. Menstrual Cycle Related Disorders. Volume 7: Frontiers in Gynecological Endocrinology. Springer International Publishing (2019): 225 p.
  10. Genazzani, A.R., Tarlatzis, B.S., eds. Frontiers in Gynecological Endocrinology. Volume 3: Ovarian Function and Reproduction – From Needs to Possibilities. Springer International Publishing (2015): 214 p.
  11. Geum, J.C., Sung, W.H., Jung-Ho, Sh., Tak, K. “Effects of intensive training on menstrual function and certain serum hormones and peptides related to the female reproductive system.” Medicine (Baltimore) 96.21 (2017): e6876.
  12. Högner, C., Sturm, S., Seger, C., Stuppner, H. “Development and validation of a rapid ultra-high performance liquid chromatography diode array detector method for Vitex agnus-castus.” J Chromatogr B Ananlyt Technol Biomed Life Sci 927 (2013): 181–90.
  13. Iacovides, S., Avidon, I., Baker, F.C. “What we know about primary dysmenorrhea today: a critical review. Review article.” Hum Reprod Update 21.6 (2015): 762–78.
  14. Khalilzadeh, E., Vafaei Saiah, G., Hasannejad, H., et al. “Antinociceptive effects, acute toxicity and chemical composition of Vitex agnus-castus essential oil.” Avicenna J Phytomed 5.3 (2015): 218–30.
  15. Leon, I. “Restoring ovarian function.” Nature Reviews Endocrinology 14 (2018): 66.
  16. Rigon, F., De Sanctis, V, Bernasconi, S., et al. “Menstrual pattern and menstrual disorders among adolescents: an update of the Italian data.” Ital J Pediatr 38 (2012): 38–46.
  17. Uzunçakmak, T., Ayaz Alkaya, S. “Effect of aromatherapy on coping with premenstrual syndrome: A randomized controlled trial.” Complement Ther Med 36 (2018): 63–7.
  18. Van Die Burger, H.G., Teede, H.J., Bone, K.M. “Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials.” Planta Med 79 (2013): 562–75.
  19. Yanqiong Zhang, Xia Mao, Jing Su, et al. “A network pharmacology-based strategy deciphers the underlying molecular mechanisms of Qixuehe Capsule in the treatment of menstrual disorders.” Clin Med 12 (2017): 23–9.
  20. Yang, L., et al. “Altered amygdalar volume and functional connectivity in primary dysmenorrhoea during the menstrual cycle.” Eur J Pain 23.5 (2019): 994-1005.
  21. Yunlai Wang, Guoqiang Li, Yu Zhou, et al. “The difference between blood‐associated and water‐associated herbs of Danggui‐Shaoyao San in theory of TCM, based on serum pharmacochemistry.” Biochemical Chromatography 30.4 (2016): 579–87.



How to Cite

Грищенко, О. В., & Бобрицкая, В. В. (2019). New patterns of menstrual disorders’ treatment – unification of the method. REPRODUCTIVE ENDOCRINOLOGY, (47), 26–32.