DOI: https://doi.org/10.18370/2309-4117.2019.46.%p

Efficiency of specific anti-inflammatory therapy in complex treatment of pregnant women with the pathological vaginal discharge syndrome

С. Н. Бакшеєв, А. В. Кузьміна, Н. В. Машир

Abstract


Vaginal discharge during pregnancy is common, but pathological vaginal discharge must be distinguished from pregnancy leukorrhea, which is normal throughout pregnancy and increases with gestational age. At pregnancy the vaginal mucosa becomes thinner and has a large surface area, which makes pregnant women more susceptible to infections. This is leads to the abnormal vaginal discharge, which in most cases is associated with a local inflammatory process. Based on this it can be concluded that antibiotic therapy alone is aimed only at the inflammation etiology, and does not allow to impact on its pathogenesis.

A prospective short-term study of 90 pregnant women aged from 25 to 41 years with the syndrome of pathological vaginal discharge was done. Pregnant women were divided into groups depending on the treatment: Group I – 30 patients who received antimicrobial therapy for 12 days;

Group II – 30 patients who received antimicrobial therapy for 12 days in combination with the anti-inflammatory drug Tantum Rosa® during 7 days;

Group III – 30 patients who received antimicrobial therapy for 12 days in combination with Tantum Rosa®, used for 7 days. After the end of treatment patients of group III received an anti-relapse course of Tantum Rosa® (1 flacon twice a week) for three months to eliminate local inflammation.

Study results showed that combination therapy with a specific anti-inflammatory drug (Tantum Rosa®) and antimicrobial drug more effectively eliminates acute symptoms and prevents relapse than monotherapy with an antimicrobial agent; additional prescription of the prophylactic course Tantum Rosa® after the end of the main therapy course is effectively prevents the pathological vaginal discharge syndrome recurrence. This is due that benzydamine hydrochloride, which is active substance of Tantum Rosa®, is a powerful inhibitor of anti-inflammatory cytokines.


Keywords


pregnant women; pathological vaginal discharge syndrome; Tantum Rosa

References


Grishchenko, V.I. Obstetrics and gynecology. Book 1. Obstetrics. Kyiv. Medicine (2017): 424 p.

Tatarchuk, T.F. “Evolution of diagnostic and treatment tactics in vaginal discharge syndrome.” Health of Ukraine. Gynecology. Themed number (2017).

Tatarchuk, T.F. “What is new in the diagnostics and treatment of abnormal vaginal discharge syndrome?” Reproductive endocrinology 6.44 (2018): 40–2.

Acobsson, B.J., Ernevi, P.P., Hidekel, L.C. “Bacterial vaginosis in early pregnancy may predispose for preterm birth and postpartum endometritis.” Acta Obstetricia et Gynecologica Scandinavica 81.11 (2002): 1006–10.

Apea-Kubi, K.A., Yamaguchi, S., Sakyi, B., et al. “Neisseria gonorrhoea, Chlamydia trachomatis, and Treponema pallidum infection in antenatal and gynecological patients at Korle-Bu Teaching Hospital, Ghana.” Japanese Journal of Infectious Diseases 57.6 (2004): 253–6.

Bradshaw, C.S., Morton, A.N., Garland, S.M., et al. “Higher-risk behavioural practices asso‐ ciated with bacterial vaginosis compared with Vaginal candidiasis.” Obstet Gynecol 106 (2005): 105.

Larsson, P.-G., Fahraeus, L., Carlsson, B., et al. “Predisposing factors for bacterial vaginosis, treatment efficacy and pregnancy outcome among term deliveries; results from a preterm delivery study.” BMC Women’s Health 7 (2007): 20.

Niccolai, L.M., Ethier, K.A., Kershaw, T.S., et al. “Pregnant adolescents at risk: sexual behaviors and sexually transmitted disease prevalence.” American Journal of Obstetrics and Gynecology 188.1 (2003): 63–70.

Passini, R. Jr, Tedesco, R.P., Marba, S.T., et al. “Brazilian multicenter study on prevalence of preterm birth and associated factors.” BMC Pregnancy and Childbirth 10 (2010): 22.

Sexton, J., Garnett, G., Rottingen, J.A. “Meta-analysis and meta-regression in interpreting study variability in the impact of sexually transmitted disease on susceptibility to HIV infection.” Sex Transm Dis 32 (2005): 351–7.

Witkin, S.S., Inglis, S.R., Polaneczky, M. “Detection of Chlamydia trachomatis and Trichomonas vaginalis by polymerase chain reaction in introital specimens from pregnant women.” Am J Obstet Gynecol 175 (1996): 165–7.


GOST Style Citations


1.       Грищенко, В.І. Акушерство і гінекологія. Книга 1. Акушерство / В.І. Грищенко. – К.: Медицина, 2017. – 424 с.

2.       Татарчук, Т.Ф. Эволюция лечебно-диагностической тактики при синдроме вагинальных выделений / Т.Ф. Татарчук // Здоровье Украины. Гинекология. – 2017. – Тематический номер.

3.       Татарчук, Т.Ф. Что нового в диагностике и лечении синдрома аномальных вагинальных выделений? / Т.Ф. Татарчук // Репродуктивная эндокринология. – 2018. – №6 (44). – С. 40–42.

4.       Acobsson, B.J., Ernevi, P.P., Hidekel, L.C. “Bacterial vaginosis in early pregnancy may predispose for preterm birth and postpartum endometritis.” Acta Obstetricia et Gynecologica Scandinavica 81.11 (2002): 1006–10.

5.       Apea-Kubi, K.A., Yamaguchi, S., Sakyi, B., et al. “Neisseria gonorrhoea, Chlamydia trachomatis, and Treponema pallidum infection in antenatal and gynecological patients at Korle-Bu Teaching Hospital, Ghana.” Japanese Journal of Infectious Diseases 57.6 (2004): 253–6.

6.       Bradshaw, C.S., Morton, A.N., Garland, S.M., et al. “Higher-risk behavioural practices asso‐ ciated with bacterial vaginosis compared with Vaginal candidiasis.” Obstet Gynecol 106 (2005): 105.

7.       Larsson, P.-G., Fahraeus, L., Carlsson, B., et al. “Predisposing factors for bacterial vaginosis, treatment efficacy and pregnancy outcome among term deliveries; results from a preterm delivery study.” BMC Women’s Health 7 (2007): 20.

8.       Niccolai, L.M., Ethier, K.A., Kershaw, T.S., et al. “Pregnant adolescents at risk: sexual behaviors and sexually transmitted disease prevalence.” American Journal of Obstetrics and Gynecology 188.1 (2003): 63–70.

9.       Passini, R. Jr, Tedesco, R.P., Marba, S.T., et al. “Brazilian multicenter study on prevalence of preterm birth and associated factors.” BMC Pregnancy and Childbirth 10 (2010): 22.

10.     Sexton, J., Garnett, G., Rottingen, J.A. “Meta-analysis and meta-regression in interpreting study variability in the impact of sexually transmitted disease on susceptibility to HIV infection.” Sex Transm Dis 32 (2005): 351–7.

11.     Witkin, S.S., Inglis, S.R., Polaneczky, M. “Detection of Chlamydia trachomatis and Trichomonas vaginalis by polymerase chain reaction in introital specimens from pregnant women.” Am J Obstet Gynecol 175 (1996): 165–7.





Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)