Perinatal aspects of preservation of pregnancy with chronic stress


  • І. А. Жабченко SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”, Ukraine
  • С. В. Тертична-Телюк SI “Lugansk State Medical University”, Ukraine
  • Н. Г. Корнієць SI “Lugansk State Medical University”, Ukraine
  • Т. М. Коваленко SI “Academician O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”, Ukraine



pregnancy, labors, stress, psychodiagnostics, pregnant women displaced persons, cortisol, prolactin, micronutritional imbalance, perinatal complications


Aim of the study is to identify the peculiar issues associated with psycho-emotional state and the related stress-associated hormones and micronutrients in pregnant-displace individuals for further improvement of programmes for antenatal research.

Dynamic prospective clinical-paraclinical examination of 96 pregnant women (experimental group) – temporary displaced individuals with gestation period of more than 22 weeks who have been treated and gave birth to their children in the Central Municipal Hospital in Rubizhne and Perinatal Centre in Severodonetsk, Lugansk region was performed. The control group consists of 39 randomly selected pregnant women for the purposes of prospective research that are living in the areas under the control of Ukraine government.

All pregnant women were examined; the evaluation of psycho-emotional state of examined pregnant was conducted with the help of screening by performing clinical interviews together with routine questioning. The questionnaires that contained the questions of Spielberg’s tests in the Khanin modification were used. Concentration of stress-associated hormones in the blood serum, calcium and magnesium was identified using the method of solid-phase immunoferment analysis and the colorimetric method.

According to the Spielberg’s test, the average score of reactive anxiety in the experimental group exceeded the analogous indicator in the control group by 1.6 times. The indicators of personal anxiety exceeded the normal indicator in the control group by 2.2 times. Cortisol concentration in the blood serum in experimental group exceeded the upper physiological standard by 5.5% and exceeded the analogous indicator in the control group by 43.4%. The increase prolactin value was yet observed in the II trimester by 13.3% compared to the upper level of physiological standard; by 20.3% compared to the average indicator of this hormone in the control group. In the III trimester its concentration in both groups was within normal ranges, but in the experimental group it was higher by 10.5%. Calcium in the blood serum in the experimental group was higher by 19.2% in comparison to the physiological standard and by 9.6% higher if compared to the analogous indicator in the control group. At the same time, the pregnant women in the experimental group have low magnesium value.

Taking into account the identified patterns, it is useful to categorise the pregnant women from among the internally displaced individuals as the group of high risk with respect to the development of obstetric and perinatal complications.

Author Biographies

І. А. Жабченко, SI “Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

MD, professor, сhief of the Department of pathology of pregnancy and childbirth

С. В. Тертична-Телюк, SI “Lugansk State Medical University”

Assistant of the Department of Obstetrics and Gynecology

Н. Г. Корнієць, SI “Lugansk State Medical University”

PhD, associate professor, head of the Department of Obstetrics and Gynecology

Т. М. Коваленко, SI “Academician O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the NAMS of Ukraine”

PhD in physical education and sport, senior researcher at the Department of Pregnancy and Childbirth Pathology


  1. Ancheva, I.A. “Psychoprophylaxis of stress during pregnancy and childbirth.” Women’s health 5.121 (2017): 32–4.
  2. Astakhov, V.M., Bacyleva, O.V., Puz, I.V. “Psychological support of pregnant women in modern conditions.” Women’s health 4.90 (2014): 58–61.
  3. Astakhov, V.M., Bacyleva, O.V., Puz, I.V. Methods of psycho-diagnostics of individual psychological peculiarities of women in obstetric-gynecologic clinic. Donetsk. NordPress (2010): 199 p.
  4. Brekhman, G.I. “The social environment of the prenatal child: constructive and destructive aspects.” Female doctor 3.41 (2012): 28–33.
  5. Vdovichenko, Y.P, Zhuk, S.I., Shchurevska, O.D. Support of pregnancy and childbirth in conditions of social stress. Kyiv. PE “Print Line” (2014): 64 р.
  6. Graf, A.V., Dunaeva, T.Y., Maklakova, A.S., et al. “Transgenerational effects of antenatal stress of different etiology.” Physiology of humans and animals 5 (2012): 529–30.
  7. Zhupieva, E.I. “Strengthening and maintaining the health of the child in terms of perinatal psychology.” Materials of the II International Scientific and Practical Conference. Penza-Moscow-Vitebsk. Sociosphere (2012): 57–9.
  8. Brekhman, G.I., Fedor-Freybergh, P. Phenomenon of violence (From domestic to global). View from a position of prenatal and perinatal psychology and medicine. Haifa. News Agalil (2005): 240 p.
  9. Ministry of Social Policy. Information about displaced persons from 05.08.2018. Available from: [htpp://], last accessed Mar 9 2019.
  10. Kutko, I.I., Panchenko, O.A., Linev, A.N. “Posttraumatic stress disorder in a military conflict. Clinical dynamics, diagnosis, treatment and rehabilitation.” Ukrainian medical journal 1.111, Vol. I/II (2016): 24–7.
  11. Маlgina, G.B., Vetchanina, E.G., Pronina, T.A. “Perinatal problems associated with psychoemotional stress during pregnancy, and their correction.” Materials of the All-Russian Conference with international Participation in Perinatal Psychology and Medicine. Ivanovo (2001): 35–8.
  12. Order of the Ministry of Health of Ukraine № 417 from 15.07.2011. “Methodical recommendations for provision of ambulatory obstetric and gynecological care.”
  13. Zhabchenko, I.A., Oleshko, V.F., Bondarenko, O.M., Syudmak, O.R. “Features of hormonal homeostasis in pregnant women with functional disorder of the obstructive function of the cervix.” Reproductive endocrinology 5.31 (2016): 85–9.
  14. Zhuk, S.I., Shchurevska, O.D. “Stress fetal programming.” Women’s health 1.117 (2017): 116–9.
  15. Larina, A.A., Grigoryan, O.R., Andreeva, E.N., Dzeranova, L.K. “Hyperprolactinemia and pregnancy (literature review).” Problems of reproduction 3 (2013): 13–7.
  16. Sebko, T.V., Heydar, L.A., Koneeva, S.S. “Hyperprolactinemia.” Russian Medical Journal 22.5 (2016): 250–9.
  17. Gorshkova, V.V., Kovaleva, A.A. “Interconnection of magnesium and calcium under stress.” Materials of the VIII International Student Scientific Conference "Student Scientific Forum – 2016". Available from: [], last accessed Mar 9, 2019.
  18. Dikke, G.B. “The role of magnesium in physiological pregnancy: proof controversy”. Medical advice 19 (2016): 96–102.
  19. Dean, C. The Magnesium Miracle. 2nd Edition (2017).
  20. Sircus, M. “Calcium Magnesium Balance.” Available from: [], last accessed Mar 9, 2019.
  21. Rayssiguier, Y., Libako, P., Nowacki, W., Rock, E. “Magnesium deficiency and metabolic syndrome: stress and inflammation may reflect calcium activation.” Magnesium Research 23.2 (2010): 73–80.
  22. Dadak, K. “Deficiency of magnesium in obstetrics and gynecology.” Obstetrics, Gynecology, Reproduction 2.7 (2013): 6–14.
  23. Zhabchenko, I.A., Oleshko, V.F. “The role of hormonal and exchange imbalance in the development of disorders of the obstructive function of the cervix and methods of its correction.” Medical aspects of women's health 2.107 (2017): 5–14.
  24. Markin, L.B., Shatilovich, K.L., Kuninets, G.Y., et al. “Аssistance to pregnant women with ischemic-cervical insufficiency in the presence of nutritional magnesium deficiency.” Women’s health 1.127 (2018): 48–52.
  25. “Does magnesium content affect the course of pregnancy: experts’ opinion.” Medical aspects of women’s health 3.108 (2017): 10–3.
  26. Anokhin, A.Y. “The role of magnesium deficiency as a stress and maladaptation problem.” Materials of the V International Scientific and Practical Conference “Young scientists in solving urgent problems of science” (2014): 51–3.
  27. Veropotvelyan, P.N., Veropotvelyan, N.P., Pogulyay, Y.S., Kholodova, N.S. “The importance of micronutrients in pregnancy.” Women’s health 8.94 (2014): 57–64.
  28. Makatsariya, A.D., Bitsadze, V.O., Hizroeva, D.H., Dzhobava, E.M. “The prevalence of magnesium deficiency in pregnant women.” Questions of gynecology, obstetrics and perinatology 5.11 (2012): 25–34.
  29. Serov, V.N., Blinov, D.V., Zimovina, U.V., Dzhobava, E.M. “The results of the study of the prevalence of magnesium deficiency in pregnant women.” Obstetrics and gynecology 4 (2014): 33–40.
  30. Tereshchenko, E. “Magnesium and pregnancy: known and new facts.” Health of Ukraine (2017): 10–1.
  31. Fofanova, I.Y. “Deficiency of magnesium and its connection with obstetric pathology.” Medical advice 5 (2013): 102–9.



How to Cite

Жабченко, І. А., Тертична-Телюк, С. В., Корнієць, Н. Г., & Коваленко, Т. М. (2019). Perinatal aspects of preservation of pregnancy with chronic stress. REPRODUCTIVE ENDOCRINOLOGY, (45), 29–33.



Pregnancy and childbirth