DOI: https://doi.org/10.18370/2309-4117.2018.44.60-63

Evaluation of Cicatridina efficacy in healing and repairing process of uterine cervix, vagina and vulva

Я. Марковська, А. Марковська, Р. Мадре

Abstract


Purpose: The aim of the study was to evaluate the efficacy of Cicatridina® application in healing and repairing process after operative procedures concerning uterine cervix, vagina and vulva and after brachytherapy due to cervical and endometrial cancer. We also analyzed Cicatridina® effect on vaginal athrophical signs in post-menopausal women.

Patients and Methods: The examined group consist of 319 women. They were divided into 2 arms. The active arm concerns 213 women who used Cicatridina®, while controlled one consists of 106 women. The effect of treatment was estimated after 6 weeks and 3 months by the visual inspection of the cervix and vagina. We also analyzed the subjective filling of patients bound to sexual intercouses by using of Visual Analogue Scale (0% – no effect; 100% – disappearance of pathological symptoms).

Results: In active arm according to control one the reparation of cervix was more often: after surgery procedures (respectively after 6 weeks 93% vs 70%; after 3 months 99% vs 89%) and after brachytherapy

(respectively after 3 months 86% vs 0%). In brachytherapy group the lack of discomfort during sexual intercourses was also more often in active arm (respectively 55% vs 0%). In postmenopausal women reduction of symptoms associated with atrophic vaginitis was observed only in active group (respectively after 6 weeks 43% vs 0%; after 3 months 57% vs 0%). In the group of patients after ephisiotomy due to delivery the relief of discomfort during sexual intercourses was also more often in active arm (respectively 94% vs 25%).

Conclusion: Cicatridina® causes fast healing of cervix after gynecological procedures. It influences improvement of atrophical, inflammatory and after radiation therapy effects which improve quality of life and comfort of vagina after brachytherapy due to cervical and endometrial cancer. Cicatridina® causes similar effect in vagina of pos-menopausal women as locally used estrogens. Cicatridina® also causes the feeling of relief and comfort in vagina after delivery as well as fast healing after episiotomy.


Keywords


repair process; uterine; cervix; vagina; vulva; brachytherapy; menopause; episiotomy; Cicatridina

References


Cauci, S., Driussi, S., De Santo, D., et al. “Prevalence of Bacterial Vaginosis and Vaginal Flora Changes in Peri- and Postmenopausal Women.” J Clin Microbiol 40 (2002): 2147–52.

Muscari Lin, E., Alkin, J., Good, B. “Premature menopause after cancer treatment.” Cancer Pract 7 (1999): 114–21.

Grigsby, P., Russel, A., Brunet, D., et al. “Late injury of cancer therapy on the female reproductive tract.” Int J Radiat Oncol Biol Phys 31 (1995): 1281–99.

Jensen, P., Groenvald, M., Klee, M., et al. “Longitudinal study of sexual function and vaginal changes after radiotherapy for cervical cancer.” Int J Radiat Oncol Biol Phys 56 (2003): 937–49.

Carranza-Lira, S., Fragoso-Diaz, N., MacGregor-Gooch, A.L., et al. “Vaginal dryness assessment in postmenopausal women using pH test strip.” Maturitas 45 (2003): 55–8.

Jackson, S., James, M., Abrams, P. “The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence.” BJOG 109 (2002): 339–44.

Gerdin, B., Hallgren, R. “Dynamic role of hyaluronan (HYA) in connective tissue activation and inflammation.” J Intern Med 242 (1997): 4955.

Tammi, R., Agren, U., Tuhkanen, A., et al. “Hyaluronan metabolism in skin.” Prog Histochem Cytochem 29 (1994): 1–81.

Itano, N., Atsumi, F., Sawai, T., et al. “Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration.” Proc Natl Acad Sci USA 99 (2002): 3609–14.

Foger, N., Marhaba, R., Zoller, M. “Involvement of CD44 in cytoskeleton rearrangement and raft reorganization in T cells.” J Cell Sci 114 (2001): 1169–78.

Savani, R., Cao, G., Pooler, P., et al. “Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis.” J Biol Chem 276 (2001): 36770–8.

Kobayashi, H., Terao, T. “Hyaluronic acid-specific regulation of cytokines by human uterine fibroblasts.” Am J Physiol 273 (1997): C1151–9.

Boselli, F., Vezzani, C., Chiossi, G. “Terapia topica con acido ialuronico dopo trattamento electrochirurgico della cervice uterina.” La Colposcopia in Italia XVIII.2 (2005): 25–8.

Lundorff, P., van Geldorp, H., Tronstad, S., et al.

“Reduction of post-surgical adhesions with ferric hyaluronate gel: a European study.” Hum Reprod 16 (2001): 1982–8.


GOST Style Citations


1.           Cauci, S., Driussi, S., De Santo, D., et al. “Prevalence of Bacterial Vaginosis and Vaginal Flora Changes in Peri- and Postmenopausal Women.” J Clin Microbiol 40 (2002): 2147–52.

2.           Muscari Lin, E., Alkin, J., Good, B. “Premature menopause after cancer treatment.” Cancer Pract 7 (1999): 114–21.

3.           Grigsby, P., Russel, A., Brunet, D., et al. “Late injury of cancer therapy on the female reproductive tract.” Int J Radiat Oncol Biol Phys 31 (1995): 1281–99.

4.           Jensen, P., Groenvald, M., Klee, M., et al. “Longitudinal study of sexual function and vaginal changes after radiotherapy for cervical cancer.”  Int J Radiat Oncol Biol Phys 56 (2003): 937–49.

5. Carranza-Lira, S., Fragoso-Diaz, N., MacGregor-Gooch, A.L., et al. “Vaginal dryness assessment in postmenopausal women using pH test strip.” Maturitas 45 (2003): 55–8.

6.           Jackson, S., James, M., Abrams, P. “The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence.” BJOG 109 (2002): 339–44.

7.           Gerdin, B., Hallgren, R. “Dynamic role of hyaluronan (HYA) in connective tissue activation and inflammation.” J Intern Med 242 (1997): 4955.

8.           Tammi, R., Agren, U., Tuhkanen, A., et al. “Hyaluronan metabolism in skin.” Prog Histochem Cytochem 29 (1994): 1–81.

9.           Itano, N., Atsumi, F., Sawai, T., et al. “Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration.” Proc Natl Acad Sci USA 99 (2002): 3609–14.

10.         Foger, N., Marhaba, R., Zoller, M. “Involvement of CD44 in cytoskeleton rearrangement and raft reorganization in T cells.” J Cell Sci 114 (2001): 1169–78.

11.         Savani, R., Cao, G., Pooler, P., et al. “Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis.” J Biol Chem 276 (2001): 36770–8.

12.         Kobayashi, H., Terao, T. “Hyaluronic acid-specific regulation of cytokines by human uterine fibroblasts.”  Am J Physiol 273 (1997): C1151–9.

13.         Boselli, F., Vezzani, C., Chiossi, G. “Terapia topica con acido ialuronico dopo trattamento electrochirurgico della cervice uterina.” La Colposcopia in Italia XVIII.2 (2005): 25–8.

14. Lundorff, P., van Geldorp, H., Tronstad, S., et al.

“Reduction of post-surgical adhesions with ferric hyaluronate gel: a European study.” Hum Reprod 16 (2001): 1982–8.





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ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)