DOI: https://doi.org/10.18370/2309-4117.2018.43.28-31

Significant improvement in cervical repair after surgery under the influence of specific anti-inflammatory therapy

В. П. Квашенко, И. Н. Сапожак

Abstract


The article describes the features of the management of patients with cervical dysplasia. After the surgical treatment of cervical neoplasia, patients experience abundant serous or serous bleeding from the genital tract, which leads to marked discomfort and secondary infection of the cervix. Secondary infection contributes to the prolongation of epithelialization of the cervix and the occurrence of a relapse of the disease.

It emphasizes the importance of the prevention of postoperative symptoms that cause discomfort in women, secondary infection of the wound surface and prolongation of epithelialization of the cervix. These symptoms occur after trauma to the cervix due to an increase in prostaglandins, histamine and pro-inflammatory cytokines.

The study showed that benzydamine hydrochloride reduces the abundance and duration of postoperative secretions from the wound surface by suppressing tissue edema and inhibiting the synthesis of proinflammatory cytokines – tumor necrosis factor and interleukin-1, which leads to increased reparative processes of the cervix epithelium. Benzydamine hydrochloride reduces capillary permeability, stabilizes lysosomal membranes, inhibits the production of adenosine triphosphate and other high-energy compounds in the processes of oxidative phosphorylation, inhibits the synthesis or inactivate prostaglandins, histamine, bradykinin, cytokines, complement factors and other endogenous non-specific “damaging factors”. It blocks the interaction of bradykinin with tissue receptors, restores impaired microcirculation and reduces pain sensitivity in the focus of inflammation, also affects the thalamic pain sensitivity centers (local blockade of PgE1, PgE2 and PgF2 alpha synthesis). The analgesic effect is due from indirect decrease in the concentration of biogenic amines, which have algenic properties, and an increase in the pain sensitivity threshold of the receptor apparatus.

Thus, benzydamine hydrochloride Tantum Rosa® is the only non-steroidal anti-inflammatory agent for topical use in gynecology, which provides rapid epithelialization of the cervix and elimination of pathological secretions due to the specific inhibition of pro-inflammatory cytokines and activation of reparative processes in the epithelium.


Keywords


cervical dysplasia; cervical excision; benzydamine hydrochloride; Tantum Rosa

References


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GOST Style Citations


1.       Манжура, Е.П. Цервикальная интраэпителиальная неоплазия (CIN). Современные подходы к диагностике, лечению и реабилитации / Е.П. Манжура // Здоровье женщины. – 2016. – №5 (111). Manzhura, E.P.

2.       Протокол «Доброякісні та передракові процеси шийки матки». Додаток до наказу МОЗ України № 676 від 31.12.2004.

3.       Bermudez, A., Bhatla, N., Leung, E. “Cancer of the cervix uteri.” International Journal of Gynecology and Obstetrics 131 (2015): S88–S95.

4.       Ferlay, J., Shin, H.R., Bray, F., et al. GLOBOCAN 2012 v2.0 cancer incidence and mortality worldwide: IARC CancerBase No. 10 [Internet]. Lyon, France. International Agency for Research on Cancer (2012).

5.       IARC&WHO Screening Group. Colposcopy and Treatment of CIN: a beginners’ manual. Ed. by J.W. Sellors, R. Sankaranarayanan. International Agency for Research on Cancer. Lyon (2003).

6.       European Quality Standards for the Treatment of Cervical Intraepithelial Neoplasia (2015).

7.       Справочник «КОМПЕНДИУМ 2016 – лекарственные препараты». Под редакцией В.Н. Коваленко.

8.       Жабченко, И.А. Современные представления о патогенезе и лечении воспалительных заболеваний нижних отделов половых путей у женщин / И.А. Жабченко // Медичні аспекти здоров’я жінки. – 2017. – № 5 (110).

9.       Sironi, M. “Differential effect of benzydamine on pro- versus anti-inflammatory cytokine production: lack of inhibition of interleukin-10 and interleukin-1 receptor antagonist.” Int J Clin Lab Res 30.1 (2000): 17–9.

10.     МОЗ України. Інформаційний лист №35-2017. «Спосіб лікування запальних захворювань шийки матки».





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ISSN 2411-1295 (Online), ISSN 2309-4117 (Print)