The effectiveness of non-steroidal anti-inflammatory drugs in the treatment of chronic pelvic pain syndrome




chronic pelvic pain syndrome, treatment, nonsteroidal anti-inflammatory drugs, DICLOSAFE


Evidence-based medicine is an approach to medical practice in which the decision on the appointment of therapeutic, diagnostic or preventive measures is based on the evidence of their effectiveness and safety.

The aim of the study. Assessment of the effectiveness and safety of the use of NSAIDs in the treatment of chronic pelvic pain in women of reproductive age.

Materials and methods. Under supervision, there were 101 women of reproductive age with chronic pelvic pain syndrome (CPPS) on the background of chronic inflammatory processes of the pelvic organs. Patients, depending on the received treatment, were randomly divided into two groups: Group I (n = 54) – complex antibiotic therapy was conducted in combination with antiplatelet agents, antihypoxants, analgesics; Group II (n = 47) – complex antibiotic (AB) therapy was performed in combination with antiplatelet agents, antihypoxants and NSAIDs (DICLOSAFE, diclofenac sodium 100 mg). The exclusion criterion was the presence of an endometriosis in a patient.

When patients were included in the study and 6 months after the completion of the treatment, a questionnaire was conducted to determine the severity of the pain syndrome, psychological status and quality of life.

Results. Positive dynamics of quantitative and qualitative characteristics of the pain syndrome, as well as dynamics of its intensity as a result of conservative treatment for 6 months in Group ІІ, was noted. Also, in Group ІІ, statistically significant data on the reduction of depression and personal anxiety are noted, in contrast to the indicators of Group I.

The results of the questionnaire of patients in group II after treatment indicated improvement of all components of physical health. Statistically significant differences with the indicators of Group I were obtained on the scale of the effect of pain on daily activity. In addition, after treatment in the Group II, the patients showed statistically significant changes in mental health and all its components.

Conclusion. Pathogenetically grounded use of NSAIDs (DICLOSAFE suppositories) in the complex treatment of patients with CPPS allows to achieve a significant improvement in quality of life indicators due to the correction of pain syndrome.

Author Biographies

Т. Г. Романенко, P.L. Shupik National Medical Academy of the Postgraduate Education

MD, professor of Obstetrics and Gynecology Department #1 

О. М. Суліменко, P.L. Shupik National Medical Academy of the Postgraduate Education

Clinical resident at Obstetrics and Gynecology Department No. 1


  1. Engeler, D.S., Baranowski, A.P., Dinis-Oliveira, P., et al. “The 2013 EAU guidelines on chronic pelvic pain: is management of chronic pelvic pain a habit, a philosophy, or a science? 10 years of development.” Eur Urol 64 (2013): 431–9.
  2. Royal College of Obstetricians and Gynaecologists. The initial management of chronic pelvic pain. Green-top Guideline No. 41. London. Royal College of Obstetricians and Gynaecologists (2012).
  3. Williams, A.C., Eccleston, C., Morley, S. “Psychological therapies for the management of chronic pain (excluding headache) in adults (review).” Cochrane Database Syst Rev 2 (2012): CD007407.
  4. Twiddy, H., Lane, N., Chawla, R., et al. “The development and delivery of a female chronic pelvic pain management programme: a specialised interdisciplinary approach.” British Journal of Pain 9.4 (2015): 233–40.
  5. Ferreira Gurian, M.B., Poli Neto, O.B., Rosa e Silva, J.C., et al. “Reduction of Pain Sensitivity is Associated with the Response to Treatment in Women with Chronic Pelvic Pain.” Pain Medicine 16 (2015): 849–54.
  6. Andrews, J., Yunker, A., Reynolds, W., et al. Noncyclic Chronic Pelvic Pain Therapies for Women: Comparative Effectiveness. Rockville, MD. Agency for Healthcare Research and Quality (2012).
  7. Chao, M.T., Abercrombie, P.D., Nakagawa, S., et al. “Prevalence and Use of Complementary Health Approaches among Women with Chronic Pelvic Pain in a Prospective Cohort Study.” Pain Medicine 16 (2015): 328–40.
  8. Ananieva, L. “Rational pain therapy – a combination of analgesics.” Drugs of Ukraine 2.91 (2005): 81–2.
  9. Rybalka, A.N., Miklin, O.P., Kamilova, I.K., et al. “Varicose veins of the pelvic floor as a cause of chronic pelvic pain.” Med.-biol. herald of Tavria 1.69 Vol. 18 (2015).
  10. Korennaya, V.V. “NSAIDs in the treatment of patients with primary dysmenorrhea.” Gynecology 1 (2015): 55–8.
  11. Sinchikhin, S.P., Mamiev, O.B., Stepanyan, L.V., et al. “Some modern aspects of pelvic inflammatory diseases.” Consilium Medicum 6 (2015): 73–6.



How to Cite

Романенко, Т. Г., & Суліменко, О. М. (2018). The effectiveness of non-steroidal anti-inflammatory drugs in the treatment of chronic pelvic pain syndrome. REPRODUCTIVE ENDOCRINOLOGY, (42), 82–86.



Drug therapy