Parvovirus B19 in the practice of obstetrician-gynecologist
Keywords:parvovirus B19, pregnancy, fetal vesicles, immunoglobulins, research
Parvovirus B19 (PV B19, infectious erythema, “fifth disease”, “slap syndrome”) is a pathogenic human single-stranded DNA virus of the family of parvovirus, which breeds in erythroid precursor cells and causes them to die. The replication of the virus occurs mainly in the precursor cells of the erythroid group (erythroblast), megacarocytes and macrophages of the bone marrow, the spleen, as well as placental endothelial cells, in the tissues of the myocardium, liver, lungs, kidneys and synovial membranes of the fetus. People with genetically absent R-antigen (1 out of 200 thousand people) are resistant to infection with PV B19. The risk of primary infection during pregnancy depends on the epidemiological situation and ranges from 1.5 to 14.5%. In 70% of infected pregnant women there will be no clinical manifestations of the disease. The risk of vertical transmission of parvovirus B19 is 35%. Up to 85% of all cases of fetal vesicles are nonimmune vesicles in the fetus. Three main mechanisms are associated with its development: intrauterine anemia, heart failure and hypoproteinemia. In the case of damage to parvovirus B19, nonimmune vesicle in the fetus develops to 27% of cases, most often – at gestational age of 10-20 weeks.
It is recommended that pregnant women who are in contact with patients with parvovirus B19 patients or who have similar clinical manifestations of the disease are consulted for the purpose of determining their immune status. Diagnosis on parvovirus B19 to perform in the case of the development of non-immune vesicles in the fetus or intrauterine fetal death. ML “DILA” offers the European quality of research – immunoblot IgM and IgG. A wide selection of biological material for PCR-research on parvovirus V19 (blood, saliva, chorion and other types of biomaterials: oral smear, liquor, amniotic fluid, bone marrow biopsy). Possibility of differentiation of immunoglobulins of mother and newborn. High accuracy of quantitative research results: sensitivity 92.2%, 100% specificity.
- SOGC Clinical Practice guideline.Parvovirus B19 Infection in Pregnancy (2014). Available from: [https://sogc.org/wp-content/uploads/2014/12/gui3161012E.pdf], last accessed Sept 13, 2018.
- Australasian Society for Infectious Diseases. Management of Perinatal Infection (2014). Available from: [https://www.asid.net.au/documents/item/368], last accessed Sept 13, 2018.
- The UK National Screening Committee.Recommendation on Parvovirus B19 Infection in Pregnancy (2014). Available from: [https://legacyscreening.phe.org.uk/policydb_download. php?doc=444], last accessed Sept 13, 2018.
- The American College of Obstetricians and Gynecologists.“ACOG Guidelines at a Glance: Key points about 4 perinatal infections.” ACOG Practice Bulletin Number 151 (2015). Available from: [http://www.contemporaryobgyn.net/obstetrics-gynecology-womens-health/acog-guidelines-glance-key-points-about-4-perinatal-infections], last accessed Sept 13, 2018.
- Neu, N., et al. “TORCH Infections”. Clin Perinatol 42 (2015): 77. Available from: [http://pngpaediatricsociety.org/wp-content/uploads/2016/03/Neu-N-TORCH-infections-Clinics-in-Perinatology-2015.pdf], last accessed Sept 13, 2018.
- Waring, G.J. “Parvovirus B19 infection: Timely diagnosis in pregnancy essential.” Case Rep Womens Health 18 (2018): e00057. DOI: 10.1016/j.crwh.2018.e00057
How to Cite
Copyright (c) 2018 О. А. Бурка, И. В. Сидорова
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.