Analysis of frequencies of polymorphism of folate-cycle genes in women from different regions of ukraine: own study and review
Keywords:pregnancy, miscarriages, polymorphism in the folate-cycle genes, hyperhomocysteinemia, folic acid, metafolin
The aim of this study were to analyze prevalence of the polymorphism of the MTHFR, MTRR, MTR genes in women with chronic miscarriages compared with the control population; to generalize Ukrainian data about MTHFR, MTRR and MTR genes polymorphism prevalence in women with chronic miscarriages and in general women population; to analyze impact of low-functional alleles of folate-cycle genes on processes related to the pregnancy course.
To study the prevalence of polymorphic variants of the folate cycle genes, 53 patients of medical centre “Family source” with a miscarriage who had one or more spontaneous miscarriages and/or frozen/regressing pregnancies in the obstetric-gynecological history were examined. The control group 1 contained of 24 conditionally healthy women with a favorable obstetrical anamnesis (absence of spontaneous abortions, complications of pregnancies and childbirths). As a control group 2 was used comparison group from the study of SI “Institute of hereditary diseases of the NAMS of Ukraine” (Lviv) – 150 women of the Western region of Ukraine without complicated genetic and obstetric history who had two or more healthy children. All groups were similar in terms of basic demographic characteristics.
Results and сonclusions. A significant percentage of women with low-functional alleles in one, several or all genes MTHFR, MTRR, MTR, was found 83% (44 of 53 studied women of main group). The genotype frequencies of these genes in patients with miscarriages were compared with population control groups from Ukraine. According to data from different regions of Ukraine, the mean frequency of low-functional polymorphic variants of gene MTHFR С677->Т exceeds 50% in the general women population. The relation/association of low-functional alleles of genes MTHFR, MTRR, MTR with disorders of various processes associated with the pregnancy course was considered.
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