Benefits of folate status correction using metafolin-contained vitamin-mineral complex

Authors

  • Е. В. Ших I.M. Sechenov FMSMU, Moscow, Russian Federation, Russian Federation
  • А. А. Махова I.M. Sechenov FMSMU, Moscow, Russian Federation, Russian Federation

Keywords:

folic acid, MTHFR, pregnancy, Metafolin

Abstract

Folic acid as substance obtained by chemical synthesis and has no own metabolic activity. Metafolin® is a synthetic compound derived from 5-methyl-tetrahydrofolate. Benefits of Metafolin include direct intake of biologically active substances; optimal form and effect of the drug even in case of homozygous and/or heterozygous genotypes 677C→T polymorphism of MTHFR. Considering high prevalence of MTHFR genetic polymorphism and its reduced activity, metafolin-contained vitamin-mineral supplements are preferred as Metafolin is the active form of folic acid which presents high bioavailability.

Author Biographies

Е. В. Ших, I.M. Sechenov FMSMU, Moscow, Russian Federation

MD, professor, head of Institute of professional education, head of the Department of clinical pharmacology and internal medicine propaedeutics

А. А. Махова, I.M. Sechenov FMSMU, Moscow, Russian Federation

Assistant of the Department of clinical pharmacology and internal medicine propaedeutics

Published

2018-04-30

How to Cite

Ших, Е. В., & Махова, А. А. (2018). Benefits of folate status correction using metafolin-contained vitamin-mineral complex. REPRODUCTIVE ENDOCRINOLOGY, (40), 88–92. Retrieved from http://reproduct-endo.com/article/view/131203

Issue

Section

Drug therapy