Role of the environment factors within inflammatory processes during polykistosis of ovaries

Authors

DOI:

https://doi.org/10.18370/2309-4117.2018.40.49-52

Keywords:

PCOS, polycystic ovary syndrome, inflammation, manganese, nickel

Abstract

Objective. To study the indicators of inflammatory process in women with polycystic ovary syndrome (PCOS) having equal body mass indices and in the absence of pathogenic infections, and to determine the content of trace elements.

Material and methods. Two groups of women were selected. The first (control) group consisted of 57 healthy women of reproductive age. In the second (main) group were 64 women with PCOS. Using PCR method excluded the presence of pathogenic infections. The analysis of the frequency of inflammatory processes was based upon microscopic characteristics of vaginal microbiocenosis.

For studying levels of manganese, nickel, zinc in serum, were selected 32 women from the control group and 44 women from the main group. Samples were analyzed on a mass spectrometer with an inductively coupled plasma. Validity of results was verified using Mann-Whitney U test, Student’s t-test and χ2.

Results. In the absence of sexually transmitted infections and equal body mass index, signs of inflammatory processes of vagina are much more common for women with PCOS. In control group, pathological samples were found in 10.52%, when as in group of women with PCOS – 84.38% (p = 0.000). For women with PCOS there was a tendency toward increase in the frequency of somatic diseases, but differences did not find statistical confirmation. The elevated levels of manganese and nickel exposure have been observed for women with PCOS. Authors associate elevated levels of zinc in the blood serum with the inflammatory process.

Conclusion. In women with PCOS in absence of sexually transmitted infections and equal body mass index, signs of inflammation are much more common. Some role in vaginal microbiocenosis and inflammatory processes can play exposure to high levels of manganese and nickel.

Author Biographies

С. В. Гуньков, L.I. Medved’s Research Center of Preventive Toxicology, Food and Chemical Safety, MOH of Ukraine

PhD, leading researcher

С. В. Бабич, L.I. Medved’s Research Center of Preventive Toxicology, Food and Chemical Safety, MOH of Ukraine

Junior researcher

References

  1. Conway, G., Dewailly, D., Diamanti-Kandarakis, E., et al.“The polycystic ovary syndrome: a position statement from the European Society of Endocrinology.” European Journal of Endocrinology 4 (2014): 1–29.
  2. Gunkov, S.V. “Increased exposure to manganese as a risk factor for ovarian polycystic syndrome.” Modern problems of toxicology, food and chemical safety 1.73 (2016): 77–9.
  3. Gunkov, S.V., Makarov, O.O. “Study of the level of exposure of the Ukraine population by nickel.” Modern problems of toxicology, food and chemical safety 2.74 (2016): 62–5.
  4. Kira, E.F. “Clinic and diagnosis of bacterial vaginosis.” Obstetrics and Gynecology 2 (1994): 32–5.
  5. Boots, C.E., Jungheim, E.S. “Inflammation and Human Ovarian Follicular Dynamics.” Semin Reprod Med 33.4 (2015): 270–5.
  6. Gunkov, S.V., Prodanchuk, M.G., Prodanchuk, G.M. “Modern approaches to the statistical processing of the results of epidemiological studies in the determination of macro- and trace elements and toxic substances in the human body.” Modern problems of toxicology, food and chemical safety 3 (2015): 65–70.
  7. The State of the Science of Endocrine Disrupting Chemicals – 2012. Geneva. United Nations Environment Programme and the WHO (2013): 296 p.
  8. Aquino, N.B., Sevigny, M.B., Sabangan, J., et al.“The role of cadmium and nickel in estrogen receptor signaling and breast cancer: metalloestrogens or not?” J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 30.3 (2012): 189–224.
  9. Manganese in Health and Disease. Ed. by L.G. Costa, M. Aschner-Cambridge: The Royal Society of Chemistry (2015): 654 p.
  10. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Nickel. U.S. Department of Health&Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry. Atlanta, Georgia (2005): 351 р.
  11. Kročková, J., Massányi, P., Sirotkin, A.V., et al.“Nickel-induced structural and functional alterations in porcine granulosa cells in vitro.” Biol Trace Elem Res 154.2 (2013): 190–5.
  12. Cheknev, S.B., Apresova, M.A., Efremova, I.E. “The production of IL-18 in the presence of γ-globulin metal complexes.” Medical immunology 15.1 (2013): 13–20.
  13. Kosei, N.V., Khominska, Z.B., Vetokh, G.V., et al. “Proinflammatory cytokines and polycystic ovary syndrome.” Reproductive endocrinology 5 (2015): 56–60.

Published

2018-04-30

How to Cite

Гуньков, С. В., & Бабич, С. В. (2018). Role of the environment factors within inflammatory processes during polykistosis of ovaries. REPRODUCTIVE ENDOCRINOLOGY, (40), 49–52. https://doi.org/10.18370/2309-4117.2018.40.49-52

Issue

Section

Gynecology

Most read articles by the same author(s)